Mayim Bialik's horrific experience on GLP-1's

[Anonymous]

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Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

I have no skin in the game but there are three well documented effects of the drugs and one significantly delayed stomach emptying. It's one of the clearest mechanisms for delayed hunger. (It's also why I am not envious of anyone that feels they need to take it. I would prefer to just not eat than have that over full feeling. I hate it and hate not pooing enough.)

I find the research really interesting. Like why would this synthetic hormone actually have benefits for heart health, slow digestion, incresae insulin in the presence of glucose. And why do so many people in our society now need a synthetic hormone? (Would be nice if 1/2 the glp research was root cause.)

You are now asserting 20 years of research has been falsified? You are crazy.

No. Not at all and I am concerned by your overly emotional reaction.

Research demonstrates that these are know affects of the drug but not why. Show me the research that explains why there have been heart health benefits, beyond those weight loss would explain. The research shows there are benefits but not why.

None of that is confusing or controversial. Your "you are crazy" is itself weird tho.

Extreme paranoia must be another side effect. Any talk about the drug seems to mean this person’s drugs will be taken from them somehow.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

I have no skin in the game but there are three well documented effects of the drugs and one significantly delayed stomach emptying. It's one of the clearest mechanisms for delayed hunger. (It's also why I am not envious of anyone that feels they need to take it. I would prefer to just not eat than have that over full feeling. I hate it and hate not pooing enough.)

I find the research really interesting. Like why would this synthetic hormone actually have benefits for heart health, slow digestion, incresae insulin in the presence of glucose. And why do so many people in our society now need a synthetic hormone? (Would be nice if 1/2 the glp research was root cause.)

You are now asserting 20 years of research has been falsified? You are crazy.

The research is based on obese and/ or diabetic patients. It is crazy to believe, with no evidence or studies in a healthy population, that you would get the same benefits and health risk reduction as a very sick population, whose lifespans are already threatened.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

I have no skin in the game but there are three well documented effects of the drugs and one significantly delayed stomach emptying. It's one of the clearest mechanisms for delayed hunger. (It's also why I am not envious of anyone that feels they need to take it. I would prefer to just not eat than have that over full feeling. I hate it and hate not pooing enough.)

I find the research really interesting. Like why would this synthetic hormone actually have benefits for heart health, slow digestion, incresae insulin in the presence of glucose. And why do so many people in our society now need a synthetic hormone? (Would be nice if 1/2 the glp research was root cause.)

You are now asserting 20 years of research has been falsified? You are crazy.

The research is based on obese and/ or diabetic patients. It is crazy to believe, with no evidence or studies in a healthy population, that you would get the same benefits and health risk reduction as a very sick population, whose lifespans are already threatened.

Has it been used to treat obesity for 20 years? I thought that was diabetes.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

I have no skin in the game but there are three well documented effects of the drugs and one significantly delayed stomach emptying. It's one of the clearest mechanisms for delayed hunger. (It's also why I am not envious of anyone that feels they need to take it. I would prefer to just not eat than have that over full feeling. I hate it and hate not pooing enough.)

I find the research really interesting. Like why would this synthetic hormone actually have benefits for heart health, slow digestion, incresae insulin in the presence of glucose. And why do so many people in our society now need a synthetic hormone? (Would be nice if 1/2 the glp research was root cause.)

You are now asserting 20 years of research has been falsified? You are crazy.

The research is based on obese and/ or diabetic patients. It is crazy to believe, with no evidence or studies in a healthy population, that you would get the same benefits and health risk reduction as a very sick population, whose lifespans are already threatened.

Has it been used to treat obesity for 20 years? I thought that was diabetes.

Many of the patients were both diabetic and obese.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

I have no skin in the game but there are three well documented effects of the drugs and one significantly delayed stomach emptying. It's one of the clearest mechanisms for delayed hunger. (It's also why I am not envious of anyone that feels they need to take it. I would prefer to just not eat than have that over full feeling. I hate it and hate not pooing enough.)

I find the research really interesting. Like why would this synthetic hormone actually have benefits for heart health, slow digestion, incresae insulin in the presence of glucose. And why do so many people in our society now need a synthetic hormone? (Would be nice if 1/2 the glp research was root cause.)

You are now asserting 20 years of research has been falsified? You are crazy.

The research is based on obese and/ or diabetic patients. It is crazy to believe, with no evidence or studies in a healthy population, that you would get the same benefits and health risk reduction as a very sick population, whose lifespans are already threatened.

Has it been used to treat obesity for 20 years? I thought that was diabetes.

Many of the patients were both diabetic and obese.

Sure, but it's not a perfect correlation. As far as I understand it, the history is as a diabetes drug and it's relatively new for treating just obesity, and my understanding is the dosage for weight loss is different.

[Anonymous]

The healthy at any size people aren’t telling you that there are severe impacts to your body from carrying excessive weight and risks to your long term metabolic health.

The diet culture influencers aren’t telling you that 95% or people who lose weight naturally gain it back within 5 years. And are wrecking their metabolisms and making it even harder to lose weight again in the process.

You have to weigh those risks against the risks of severe side effects of long term use of GLP1s for you.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

I have no skin in the game but there are three well documented effects of the drugs and one significantly delayed stomach emptying. It's one of the clearest mechanisms for delayed hunger. (It's also why I am not envious of anyone that feels they need to take it. I would prefer to just not eat than have that over full feeling. I hate it and hate not pooing enough.)

I find the research really interesting. Like why would this synthetic hormone actually have benefits for heart health, slow digestion, incresae insulin in the presence of glucose. And why do so many people in our society now need a synthetic hormone? (Would be nice if 1/2 the glp research was root cause.)

You are now asserting 20 years of research has been falsified? You are crazy.

The research is based on obese and/ or diabetic patients. It is crazy to believe, with no evidence or studies in a healthy population, that you would get the same benefits and health risk reduction as a very sick population, whose lifespans are already threatened.

Type 2 diabetes and obesity run strongly in my family. I feel like a ticking time bomb. Since diet and exercise has failed, I would rather use these drugs now to help keep my weight under control and reduce- if not practially eliminate- my risk of becoming diabetic and obese in the future. What's the saying? Prevention is better than the cure?

[Anonymous]

Anonymous wrote:The healthy at any size people aren’t telling you that there are severe impacts to your body from carrying excessive weight and risks to your long term metabolic health.

The diet culture influencers aren’t telling you that 95% or people who lose weight naturally gain it back within 5 years. And are wrecking their metabolisms and making it even harder to lose weight again in the process.

You have to weigh those risks against the risks of severe side effects of long term use of GLP1s for you.

This is fair.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

I have no skin in the game but there are three well documented effects of the drugs and one significantly delayed stomach emptying. It's one of the clearest mechanisms for delayed hunger. (It's also why I am not envious of anyone that feels they need to take it. I would prefer to just not eat than have that over full feeling. I hate it and hate not pooing enough.)

I find the research really interesting. Like why would this synthetic hormone actually have benefits for heart health, slow digestion, incresae insulin in the presence of glucose. And why do so many people in our society now need a synthetic hormone? (Would be nice if 1/2 the glp research was root cause.)

You are now asserting 20 years of research has been falsified? You are crazy.

The research is based on obese and/ or diabetic patients. It is crazy to believe, with no evidence or studies in a healthy population, that you would get the same benefits and health risk reduction as a very sick population, whose lifespans are already threatened.

Type 2 diabetes and obesity run strongly in my family. I feel like a ticking time bomb. Since diet and exercise has failed, I would rather use these drugs now to help keep my weight under control and reduce- if not practially eliminate- my risk of becoming diabetic and obese in the future. What's the saying? Prevention is better than the cure?

If you are not obese and don't have diabetes, where is the failure?

[Anonymous]

Glp is occurs naturally in the body. Eat veg before protein, then carbs. Eat slowly and chew your food well. Glp kicks in 20-30 minutes into a meal. Give your body time to do its job. This approach is like volumetrics, clean eating and mindfulness all together. I am following this approach and will report back. I have 20# to lose.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

I have no skin in the game but there are three well documented effects of the drugs and one significantly delayed stomach emptying. It's one of the clearest mechanisms for delayed hunger. (It's also why I am not envious of anyone that feels they need to take it. I would prefer to just not eat than have that over full feeling. I hate it and hate not pooing enough.)

I find the research really interesting. Like why would this synthetic hormone actually have benefits for heart health, slow digestion, incresae insulin in the presence of glucose. And why do so many people in our society now need a synthetic hormone? (Would be nice if 1/2 the glp research was root cause.)

You are now asserting 20 years of research has been falsified? You are crazy.

The research is based on obese and/ or diabetic patients. It is crazy to believe, with no evidence or studies in a healthy population, that you would get the same benefits and health risk reduction as a very sick population, whose lifespans are already threatened.

Type 2 diabetes and obesity run strongly in my family. I feel like a ticking time bomb. Since diet and exercise has failed, I would rather use these drugs now to help keep my weight under control and reduce- if not practially eliminate- my risk of becoming diabetic and obese in the future. What's the saying? Prevention is better than the cure?

If you are not obese and don't have diabetes, where is the failure?

I'm not obese and diabetic. I am slightly overweight heading in the wrong direction.

[Anonymous]

The thing is, most of the research coming out now that more and more people are on GLP-1s is showing a myriad of benefits - sleep apnea reduction, lower cancer rates, significant benefits in those with addiction, and more. You can’t just discount the emerging science.

And for those who say “well those benefits are just the benefits of weight loss in general”, sure. But a) there is growing evidence some of these benefits are independent of the amount of weight lost and b) a lot of people on these meds would never have lost a significant amount of weight on their own (whether bc they have an underlying issue or just couldn’t sustain weight loss efforts, it is irrelevant). So we demonize the medication that will give them health and longevity bc…why? We don’t judge people for taking meds for any disease besides obesity. Make it make sense.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

I have no skin in the game but there are three well documented effects of the drugs and one significantly delayed stomach emptying. It's one of the clearest mechanisms for delayed hunger. (It's also why I am not envious of anyone that feels they need to take it. I would prefer to just not eat than have that over full feeling. I hate it and hate not pooing enough.)

I find the research really interesting. Like why would this synthetic hormone actually have benefits for heart health, slow digestion, incresae insulin in the presence of glucose. And why do so many people in our society now need a synthetic hormone? (Would be nice if 1/2 the glp research was root cause.)

You are now asserting 20 years of research has been falsified? You are crazy.

The research is based on obese and/ or diabetic patients. It is crazy to believe, with no evidence or studies in a healthy population, that you would get the same benefits and health risk reduction as a very sick population, whose lifespans are already threatened.

If anyone is taking these meds despite being healthy, and not overweight, then they're taking them fully off label and the benefits would never outweigh the risks because there are no proven benefits, if you are not already overweight with health issues or morbidly obese.

[Anonymous]

Anonymous wrote:The thing is, most of the research coming out now that more and more people are on GLP-1s is showing a myriad of benefits - sleep apnea reduction, lower cancer rates, significant benefits in those with addiction, and more. You can’t just discount the emerging science.

And for those who say “well those benefits are just the benefits of weight loss in general”, sure. But a) there is growing evidence some of these benefits are independent of the amount of weight lost and b) a lot of people on these meds would never have lost a significant amount of weight on their own (whether bc they have an underlying issue or just couldn’t sustain weight loss efforts, it is irrelevant). So we demonize the medication that will give them health and longevity bc…why? We don’t judge people for taking meds for any disease besides obesity. Make it make sense.

I can actually understand why some people "demonize" GLP-1s. I imagine these are people who had to work hard their whole lives to maintain their weight. They always said no to cake. They got up early to workout. They went out jogging when they'd rather be on the couch scrolling their phone. They have deprived themselves. And now they see others get the same result without lifting a finger.

Imagine you've studied hard all semester. You didn't go out on your Friday nights, you turned off the TV, you studied. At the final, another kid, who didn't even show up to class, swallows a magic pill before class which makes him super smart and he scores even higher than you. Wouldn't you feel... I dunno... frustrated? Jealous?

We as a society have been told our whole lives that there's no shortcuts. You have to put in the hard work, develop discipline. GLP-1s are turning that on its head. And yes, the formal line is that GLP-1s are supposed to be taken in conjunction with lifestyle changes, a healthy diet and strength training. But in reality? This is America baby. Have you seen our population? A LOT of GLP-1 users (none on here, obviously - I'm talking about Billy Bob down in rural Arkansas) are making zero lifestyle changes. There are pre diabetic people who are actually TRYING to push their body into diabetes so they can get the drug covered by insurance. 10 years ago, when their A1C came back at 5.8, they'd cut back on the cake and ice cream. Today, they're like, bring me the Big Gulp, I need to hit 6.0 or higher so I can get that drug, keep doing my thing and look like Kate Moss.

[Anonymous]

Anonymous wrote:

Anonymous wrote:The thing is, most of the research coming out now that more and more people are on GLP-1s is showing a myriad of benefits - sleep apnea reduction, lower cancer rates, significant benefits in those with addiction, and more. You can’t just discount the emerging science.

And for those who say “well those benefits are just the benefits of weight loss in general”, sure. But a) there is growing evidence some of these benefits are independent of the amount of weight lost and b) a lot of people on these meds would never have lost a significant amount of weight on their own (whether bc they have an underlying issue or just couldn’t sustain weight loss efforts, it is irrelevant). So we demonize the medication that will give them health and longevity bc…why? We don’t judge people for taking meds for any disease besides obesity. Make it make sense.

I can actually understand why some people "demonize" GLP-1s. I imagine these are people who had to work hard their whole lives to maintain their weight. They always said no to cake. They got up early to workout. They went out jogging when they'd rather be on the couch scrolling their phone. They have deprived themselves. And now they see others get the same result without lifting a finger.

Imagine you've studied hard all semester. You didn't go out on your Friday nights, you turned off the TV, you studied. At the final, another kid, who didn't even show up to class, swallows a magic pill before class which makes him super smart and he scores even higher than you. Wouldn't you feel... I dunno... frustrated? Jealous?

We as a society have been told our whole lives that there's no shortcuts. You have to put in the hard work, develop discipline. GLP-1s are turning that on its head. And yes, the formal line is that GLP-1s are supposed to be taken in conjunction with lifestyle changes, a healthy diet and strength training. But in reality? This is America baby. Have you seen our population? A LOT of GLP-1 users (none on here, obviously - I'm talking about Billy Bob down in rural Arkansas) are making zero lifestyle changes. There are pre diabetic people who are actually TRYING to push their body into diabetes so they can get the drug covered by insurance. 10 years ago, when their A1C came back at 5.8, they'd cut back on the cake and ice cream. Today, they're like, bring me the Big Gulp, I need to hit 6.0 or higher so I can get that drug, keep doing my thing and look like Kate Moss.

You’re proving my point though. You’re saying the only people who “deserve” health are the ones who sacrificed for it. What other disease do we do this for? This line of reasoning also discounts those who do the “right” things but are unable to lose significant weight. I know everyone wants to blame the fat people for their slovenliness, but obesity is COMPLEX. I know you don’t want to accept that, but it’s a fact. If you trust science in other arenas of health, you have to here too.

ALSO, for most people weight does not just fall off on these meds. You have to eat protein, hydrate, lift weights, and have frequent check-ins with your doctor. I know you also don’t want to believe this.