Mayim Bialik's horrific experience on GLP-1's

[Anonymous]

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Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

[Anonymous]

Anonymous wrote:The fact that this was published in Bari Weiss’s The Free Press should be a great sign to discount it entirely.

+1000000000000000

[Anonymous]

Agree with the nutjob posts. That and the Bari Weiss connection are sufficient to not take her seriously.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

If you're not overweight or diabetic why do you want to take a GLP1??

I was below the bmi guidelines, but after taking and losing 20 pounds my blood pressure and cholesterol are now back to normal

[Anonymous]

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Anonymous wrote:

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Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

So I guess it's either be fat and die of coronary artery disease, like you see to want me to, or be thin and "find out" if the safety data from the last 25ish years was falsified and I'm actually going to die a quicker and MORE horrible death. Must be nice to not have to worry about either scenario, but here you are, shaming people into treating their obesity with an effective medication, despite possible unknown long term (40+ years?) side effects.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

I have no skin in the game but there are three well documented effects of the drugs and one significantly delayed stomach emptying. It's one of the clearest mechanisms for delayed hunger. (It's also why I am not envious of anyone that feels they need to take it. I would prefer to just not eat than have that over full feeling. I hate it and hate not pooing enough.)

I find the research really interesting. Like why would this synthetic hormone actually have benefits for heart health, slow digestion, incresae insulin in the presence of glucose. And why do so many people in our society now need a synthetic hormone? (Would be nice if 1/2 the glp research was root cause.)

[Anonymous]

Anonymous wrote:I had worse side effects on one of my birth control pills. Should we have a huge article about how terrible all birth control pills are?

Kudos to you - you clearly don’t read much on this site. BC is discussed routinely on this site, and yes, there are people who take over the discussion to talk about how terrible it is.

[Anonymous]

It sounds like she has a whole host of other medical issues, so no wonder she couldn't tolerate the GLP-1.

I've been on one for almost a year and the only side effect I've had is increased hair loss and I am really unsure if it's because of the GLP-1 or because I'm menopausal and not yet on HRT.

Also, her "researcH' is pretty anecdotal - "online forums" where everyone goes to complain.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLP-1s have been around for diabetes treatment for over 20 years.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLP-1s have been around for diabetes treatment for over 20 years.

...which is an entirely different population than otherwise healthy people who *want to drop 20 pounds easily. The studies, lowered cancer risks, etc are based on people whose diseases and obesity would've done them in without treatment.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

I have no skin in the game but there are three well documented effects of the drugs and one significantly delayed stomach emptying. It's one of the clearest mechanisms for delayed hunger. (It's also why I am not envious of anyone that feels they need to take it. I would prefer to just not eat than have that over full feeling. I hate it and hate not pooing enough.)

I find the research really interesting. Like why would this synthetic hormone actually have benefits for heart health, slow digestion, incresae insulin in the presence of glucose. And why do so many people in our society now need a synthetic hormone? (Would be nice if 1/2 the glp research was root cause.)

You are now asserting 20 years of research has been falsified? You are crazy.

[Anonymous]

Anonymous wrote:

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Anonymous wrote:First she's a nut job and second this is true of all meds. Some people don't tolerate certain drugs. Nothing to see here.

Exactly. The page of small prints comes with every medication? It lists every bad reaction happened to someone, even if it was less than one in a million. Should we ban all medications?

I don't think anyone is saying ban, just weigh the risks.

So, you mean, consult with your physician before starting a medication (which has to be prescribed by a doctor)?

Well yeah, if it's a real consult, where if your doctor tells you that your labs are good and you don't need the medication, you're willing to accept that.

Interestingly, it was my NP who brought it up to me at 2 different annual physicals 1 year apart. My bmi was like 25.5 and only going up.

This didn’t happen. No medical professional is going to push these on you for a BMI of 25 unless your labs are horrible. The people using it at that BMI are using compounded versions that contain - well who the hell knows - in them. That should be the bigger concern, not using the actual prescriptions, but the compounded versions that aren’t as regulated.

The conversation sure did happen, twice. She specifically said with BMI of 25 I could qualify but insurance would not cover it. Labs are "normal" but not as good as my baseline from 10 or 20 years ago.

Also, compounded versions are perfectly fine from a reputable pharmacy. It's not like it's someone mixing up glp1 in their garage. I get mine from an FDA inspected facility with no problem at all. I am RN though haven't worked in that capacity in a while and we often sent patients to get compounded medications for their children so I really have no qualms about obtaining it from a reputable facility.

[Anonymous]

Anonymous wrote:It sounds like she has a whole host of other medical issues, so no wonder she couldn't tolerate the GLP-1.

I've been on one for almost a year and the only side effect I've had is increased hair loss and I am really unsure if it's because of the GLP-1 or because I'm menopausal and not yet on HRT.

Also, her "researcH' is pretty anecdotal - "online forums" where everyone goes to complain.

Yes, when you have significant health issues everything is more complicated. I have a couple of conditions (including physical disabilities) and am on a GLP1. I have nausea and fatigue the day after most shots but it also helped my IBS-D and joint pain so overall it’s a huge benefit

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I mean, maybe I'm older than most of y'all, but in decades past, the horror stories were always out there about weight loss drugs. Because of the old drugs, I will not take any of the new drugs.

Would you take a two-decade old diabetes drug? What about a new diabetes drug? These weren't even developed for weight loss. Weight loss was discovered after those taking it for diabetes were dropping weight.

And thus I, who does not have diabetes, would rather wait until it's been used safely on people like me for that period of time at the weight loss dosage.

Same. I'm not overweight nor diabetic and have no need to be a guinea pig. Would be nice if there was a wonder drug, but there's a lot we don't know yet about long term usage.

Many of these people are finally skinny "effortlessly", they will withstand nausea, vomiting, sulphur burps, diarrhea, etc, etc. You can't pry that needle or pill from their bony little hands. The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. See also: fen phen.

What is the link between GLP1 usage and increased cardiac risk, or increased gastric cancer risk?

There isn't one. Did you mean to insinuate otherwise?

No, I'm literally asking the poster above me who says "The overseeing entity (usda?) will have to issue a ban on these drugs for their population and remove them to get them to stop....unless gastric cancers or dehydration/heart issues stops them first. "

Be patient. It took 10+ years before fen-phen was pulled as a combo for weight loss. It was a miracle drug! just as glps are being touted. Glps work by slowing digestion. There is a reason why we eliminate our waste typically between 24 and 72 hours after eating. Can you connect the dots, or are you going to wait for the find out stage of this?

GLPs don't "work by slowing digestion", if you believe that then how can you also believe the tales of rampant diarrhea?

And they've been on the market for WELL more than 10 years, so what's the next goalpost?

I have no skin in the game but there are three well documented effects of the drugs and one significantly delayed stomach emptying. It's one of the clearest mechanisms for delayed hunger. (It's also why I am not envious of anyone that feels they need to take it. I would prefer to just not eat than have that over full feeling. I hate it and hate not pooing enough.)

I find the research really interesting. Like why would this synthetic hormone actually have benefits for heart health, slow digestion, incresae insulin in the presence of glucose. And why do so many people in our society now need a synthetic hormone? (Would be nice if 1/2 the glp research was root cause.)

You are now asserting 20 years of research has been falsified? You are crazy.

No. Not at all and I am concerned by your overly emotional reaction.

Research demonstrates that these are know affects of the drug but not why. Show me the research that explains why there have been heart health benefits, beyond those weight loss would explain. The research shows there are benefits but not why.

None of that is confusing or controversial. Your "you are crazy" is itself weird tho.