Mournjaro now approved for weight loss under name Zepbound

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Eli Lilly will have a savings card that will bring the price for Zepbound down to $550. It’s still expensive but more palatable than $1000+

I’ve been on Mounjaro for a year and lost nearly 70 pounds. It’s been amazing and has helped me change my eating habits. I can now exercise more - less pain and issues due to being at a lower weight.

Did you or do you have bad side effects like some people report having on Wegovy? I saw some reported side effects with this drug of mild gastric upset.

NP. I had pretty bad reflux at night so couldn't eat much after 5pm. I had reflux before the medicine, like I normally couldn't eat after about 7pm, but this ramped it up. That was my only side effect. I stopped it for a colonoscopy at the end of the summer and haven't gotten back on. I haven't gained any weight back either, so pretty happy about that. I was on it 6 months and lost 25 lbs.

I had an almost identical experience. I lost 35 pounds before getting off Wegovy last June. I would have stayed on, but I lost enough weight that my insurance company would no longer pay for it. Haven't lost more weight but haven't gained any back either.

Your experience is not the norm. Even the pharma companies say that 2/3 of GLP1 patients out the weight back on when they discontinue the drug. From what I’m seeing in the wild, it’s much higher than that.

Do you have a source?

Straight from NovoNordisk. As many doctors have found, people who go off these drugs often regain more.
https://www.cnbc.com/2023/03/29/people-taking-obesity-drugs-ozempic-and-wegovy-gain-weight-once-they-stop-medication.html

Isn’t that true of all weight loss?

[Anonymous]

Anonymous wrote:

Anonymous wrote:Eli Lilly will have a savings card that will bring the price for Zepbound down to $550. It’s still expensive but more palatable than $1000+

I’ve been on Mounjaro for a year and lost nearly 70 pounds. It’s been amazing and has helped me change my eating habits. I can now exercise more - less pain and issues due to being at a lower weight.

Did you or do you have bad side effects like some people report having on Wegovy? I saw some reported side effects with this drug of mild gastric upset.

Thankfully I’ve had almost no issues. I started at 2.5mg for a month and then moved up to 5mg for month 2. Those first two months were marked by body aches and fatigue. But then my body adjusted and I had no other issues.

I do get heartburn if I indulge in anything too spicy or greasy so I’ve learned to avoid those or take Zantac.

No issues with constipation or diarrhea. No nausea or vomiting ever. I do get full quickly and stay full longer so I tend to only eat one main meal and then smaller bites though out the day.

[Anonymous]

^^ PP again. I’ve been able to workout and have used Peloton for spin and bootcamp classes.

I’ve gone from a total novice on bike to building my endurance up to 30 minute rides. I can now stand and do the climbs at 50-60 resistance. That was all but impossible at 273#.

I take Tunde’s boot camps and while my arms will never look like hers, I have gotten stronger.

My eating habits have changed - I focus on protein first and aim for 85-100g a day. I drink mostly water and cut down on sweets.

All my labs have improved and I feel better.

I gained weight consistently over the past decade once my knee blew out and I had to stop running. I used to run a lot and completed several races including the GW Parkway 10 miler and 2 half marathons.

I truly feel like I’ve gotten my health back in order and will continue to take Mounjaro for at least another year to lose the next 50#.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:The muscle loss on these drugs is brutal. That’s why the Ozempic face is so striking—weight loss plus muscle wasting.

Weight loss shows in your face. It has nothing to do with the drug.

Are you contesting the muscle wasting side effect or just the widely noted Ozempic face?

GLP1 patients look especially haggard compared to other weight loss patients. This look is so distinct that it’s been widely noted. That’s what you’d expect when the drug causes muscle wasting.

I can understand why pharma allies are pushing the “it’s just weight loss” stuff though. I would be too if my company had a cash cow like this!

No, they don't. Have you ever seen a bariatric surgery patient?? Losing large amounts of fat rapidly leads to muscle loss. It's just a fact, it takes a lot of work to maintain lean mass while losing fat, and even with perfect macros and strength training it's impossible to maintain 100%. That's why body builders bulk and then they cut. It happens whether you lose weight via weight loss surgery, GLP1, or any other method of severe calorie restriction that leads to rapid weight loss.

Just because People magazine or whatever has had "BEWARE OZEMPIC FACE" splashed across the cover for a few months doesn't mean there's any scientific basis to it. Use your brain.

[Anonymous]

I don’t get the “haggard face” thing with the muscle thing because how much muscle can be in your face? But anyway I look the same as other times I have lost a bunch of weight.

[Anonymous]

Anonymous wrote:My understanding is that you need to be in these drugs for the rest of your lives or the weight will come right back.

Wait until you hear about food. Once I started eating that stuff, I needed to keep doing it nearly every damn day.

[Anonymous]

Anonymous wrote:The muscle loss on these drugs is brutal. That’s why the Ozempic face is so striking—weight loss plus muscle wasting.

Wrong.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:My understanding is that you need to be in these drugs for the rest of your lives or the weight will come right back.

That is the case for a number of drugs including e.g. cholesterol and diabetes medications.

The issue is the cost. The maintenance drugs you mentioned costs pennies. How many can pay $1000 per month when insurance says they are no longer obese and won't cover it?

How much does treating or living with the effects of obesity cost? (Although, frankly, that's a better argument for insurers paying for these drugs. If obesity is as destructive as we've been led to believe, these drugs should be regarded as a preventative cost-saving measure.)

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:The muscle loss on these drugs is brutal. That’s why the Ozempic face is so striking—weight loss plus muscle wasting.

Weight loss shows in your face. It has nothing to do with the drug.

Are you contesting the muscle wasting side effect or just the widely noted Ozempic face?

GLP1 patients look especially haggard compared to other weight loss patients. This look is so distinct that it’s been widely noted. That’s what you’d expect when the drug causes muscle wasting.

I can understand why pharma allies are pushing the “it’s just weight loss” stuff though. I would be too if my company had a cash cow like this!

Mmmm, conspiracy. I got my COVID shot and my cell reception has never been better.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Eli Lilly will have a savings card that will bring the price for Zepbound down to $550. It’s still expensive but more palatable than $1000+

I’ve been on Mounjaro for a year and lost nearly 70 pounds. It’s been amazing and has helped me change my eating habits. I can now exercise more - less pain and issues due to being at a lower weight.

Did you or do you have bad side effects like some people report having on Wegovy? I saw some reported side effects with this drug of mild gastric upset.

NP. I had pretty bad reflux at night so couldn't eat much after 5pm. I had reflux before the medicine, like I normally couldn't eat after about 7pm, but this ramped it up. That was my only side effect. I stopped it for a colonoscopy at the end of the summer and haven't gotten back on. I haven't gained any weight back either, so pretty happy about that. I was on it 6 months and lost 25 lbs.

I had an almost identical experience. I lost 35 pounds before getting off Wegovy last June. I would have stayed on, but I lost enough weight that my insurance company would no longer pay for it. Haven't lost more weight but haven't gained any back either.

Your experience is not the norm. Even the pharma companies say that 2/3 of GLP1 patients out the weight back on when they discontinue the drug. From what I’m seeing in the wild, it’s much higher than that.

Do you have a source?

Straight from NovoNordisk. As many doctors have found, people who go off these drugs often regain more.
https://www.cnbc.com/2023/03/29/people-taking-obesity-drugs-ozempic-and-wegovy-gain-weight-once-they-stop-medication.html

Isn’t that true of all weight loss?

Yes.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Eli Lilly will have a savings card that will bring the price for Zepbound down to $550. It’s still expensive but more palatable than $1000+

I’ve been on Mounjaro for a year and lost nearly 70 pounds. It’s been amazing and has helped me change my eating habits. I can now exercise more - less pain and issues due to being at a lower weight.

Did you or do you have bad side effects like some people report having on Wegovy? I saw some reported side effects with this drug of mild gastric upset.

NP. I had pretty bad reflux at night so couldn't eat much after 5pm. I had reflux before the medicine, like I normally couldn't eat after about 7pm, but this ramped it up. That was my only side effect. I stopped it for a colonoscopy at the end of the summer and haven't gotten back on. I haven't gained any weight back either, so pretty happy about that. I was on it 6 months and lost 25 lbs.

I had an almost identical experience. I lost 35 pounds before getting off Wegovy last June. I would have stayed on, but I lost enough weight that my insurance company would no longer pay for it. Haven't lost more weight but haven't gained any back either.

Your experience is not the norm. Even the pharma companies say that 2/3 of GLP1 patients out the weight back on when they discontinue the drug. From what I’m seeing in the wild, it’s much higher than that.

Do you have a source?

Straight from NovoNordisk. As many doctors have found, people who go off these drugs often regain more.
https://www.cnbc.com/2023/03/29/people-taking-obesity-drugs-ozempic-and-wegovy-gain-weight-once-they-stop-medication.html

Isn’t that true of all weight loss?

Not to the same extent. As we stated, GLP1s cause massive muscle loss, which lowers metabolism.

[Anonymous]

Anonymous wrote: ^^ PP again. I’ve been able to workout and have used Peloton for spin and bootcamp classes.

I’ve gone from a total novice on bike to building my endurance up to 30 minute rides. I can now stand and do the climbs at 50-60 resistance. That was all but impossible at 273#.

I take Tunde’s boot camps and while my arms will never look like hers, I have gotten stronger.

My eating habits have changed - I focus on protein first and aim for 85-100g a day. I drink mostly water and cut down on sweets.

All my labs have improved and I feel better.

I gained weight consistently over the past decade once my knee blew out and I had to stop running. I used to run a lot and completed several races including the GW Parkway 10 miler and 2 half marathons.

I truly feel like I’ve gotten my health back in order and will continue to take Mounjaro for at least another year to lose the next 50#.

Sounds a lot like what I'm seeing with my wife's experience. Her hunger drive just isn't as intense. Consequently, she's more deliberate about what she eats. (To her prescribing doctor's credit, this is also likely at least partially function of seeing a dietician as part of her overall treatment plan.) Meanwhile, her exercise has intensified, in part, because her body isn't limiting her ability to exercise as much as it did. Her strength and stamina are way up.

[Anonymous]

If you eat a normal diet , even adding some treats , you can lose 2 pounds a week safely . It takes time, but in the long run it is safer than these meds.

[Anonymous]

New poster. I lost 18 pounds in two months on ozempic. Two more to go. Menopause and a back injury caused me to gain weight, and I’m thankful for ozempic.

We don’t order out as often, and I stopped drinking wine. The wine aversion is an amazing side effect for someone like me, but I know that others might hate this. I just don’t want it anymore. No more Starbucks muffins or ice cream. No more junk food in our house. I probably save $500 a month. We went to the movies and saved at least $40 because we didn’t have wine and snacks.

I’ll go down to a baby dose after the holidays. I like being thin. I started out with a lot of lean muscle mass, and I exercise a lot, so I’m not concerned about losing muscle. My face looks a million times better. It looked bloated and unhealthy before.

Side effects are manageable but not great. The weight comes off immediately so you have lots of incentive to push through, but it is not easy to feel sick or nauseous.

For me, it was worth it. I don’t know if it would have been more overwhelming if I needed to lose 50 pounds and be on it for years. It does change your lifestyle.

[Anonymous]

Anonymous wrote:

Anonymous wrote:The muscle loss on these drugs is brutal. That’s why the Ozempic face is so striking—weight loss plus muscle wasting.

Wrong.

I agree. People generally look much better and younger with thinner faces.

Any rapid weight loss causes thinner faces. The literature says it fills back in a bit in time.