Friend who works in pharma went on a rant about how bad Ozempic etc is for people. ?

[Anonymous]

Anonymous wrote:Because most people view the universe through the lens of their own experience and cannot fathom that it is different for other people.

I have drunk alcohol since my teens, yet I have never had a problem with alcohol. I can take it or leave it. I am not into shopping, never done it to excess. Don't have any interest in gambling. I can sit down and take a standardized test and ace it, no sweat. But put me in a room with food and my brain goes haywire. I cannot control myself.

That's how MY brain works. Not how others' work.

Nothing helped me understand this more than having a child with special needs whose brain works so differently than mine.

So much of what we all do in a day is controlled by our brain and body chemistry, and we're just now realizing this when it comes to obesity.

Society still stigmatizes alcoholism, drug addiction, neurodiversities, clinical depression, mental illness, but not as much as it stigmatizes and in fact demonizes obesity.

I hope we are making progress. I believe we are. But it is slow going.

Disagree.

--someone with both a mental illness and obesity (well, I think technically I'm no longer obese as of this month thanks to Wegovy)

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Your friend is probably very insecure about his own weight, and also anxious about trying this drug himself because he's in a position to read about the clinical trial dossiers and post-commercialization reports on severe side effects.

I have to say, as a biologist working in pharma, he's not wrong: some people have died due to complications from slow-moving bowels, and a lot of people taking this drug will realize they can't stop taking it, otherwise the weight will come back. If I had weight issues, I would hesitate to try it too, because I've read some research articles about it that are quite disturbing!

Let's just say it's not the miracle drug people think it is. I hope your husband and sibling are very educated about it and know the limitations of their medication.

I totally disagree. I think it is a miracle drug. 75 percent of Americans are overweight. This drug helps tremendously, with relatively manageable side effects. To ignore that is so short sighted.

But people will argue vehemently that you can be fit and fat. Why are we suddenly rushing to use drugs to control weight if it doesn’t matter? Also, let’s see how these lab rats fare in a few years after continued use.

Not all people are the same.
You can be fit and fat.
Fat also increases some risks like diabetes.

Everyone including ops friend should myob

There is not a single objective health measure that improves by carrying excessive body fat other than being dramatically underweight. That's reality.

Reality is that you and the rest of the fatphobes on this forum/in this culture don't give a rat's behind about a fat stranger's health. Fat bodies are an acceptable target for your concern trolling, othering, and ableism. That's it. You hide behind "health concerns" but if you really gave a damn about a stranger's health, you wouldn't lead by insulting their intelligence, framing yourself as superior because you wear a smaller size, and then treating them like a hapless idiot who needs your help or your opinion.

Being judged for existing in the body you've got isn't good for anyone's health, doesn't motivate people to change their body shape, and can actively harm people to the point of suicidal ideation and self-harm.

There's not a single objective health measure that improves by being judged by a stranger. THAT is reality, so STFU.

You might consider that when you quote a post, the prior discussion was included.

If you bothered reading, you would find I was responding to the notion that fitness and being fat can coexist. That’s just not true. In extremely rare cases people with an obese BMI may not be carrying around significant body fat far in excess of what’s healthy. That’s not the 99.9% of Americans in the obese category. That’s what I was responding to that caused you to get all butt hurt.

So no, there is not a single objective health measure that improves by carrying around excess body fat. Maybe go work on that instead of being butt hurt by people pointing out facts. Facts aren’t judgement - you just turn them into something about you because you don’t like general facts. Maybe also work on that while you are at it.

So you're an idiot, as well as an ass? Cool. Thanks for the information.

You are free to explain how there IS a single objective health measure that improves by carrying around excess body fat.

Fat women are less likely to have osteoporosis. Constant weight-bearing exercise 💪

[Anonymous]

Anonymous wrote:Did you know in Europe they don’t even use it for diabetic patients? They’re so far advanced medically than us, they already know it’s bad for you. But Americans are so stupid, they’ll use anything for a quick fix instead of just not eating 20 Oreos

Wow. Look at this insight. All we need to do to fight obesity is "not eat 20 oreos."

Seriously, PP, you have extreme ignorance with regard to the emerging science on obesity (and apparently a desperate need to be a nasty offensive human as well).

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Your friend is probably very insecure about his own weight, and also anxious about trying this drug himself because he's in a position to read about the clinical trial dossiers and post-commercialization reports on severe side effects.

I have to say, as a biologist working in pharma, he's not wrong: some people have died due to complications from slow-moving bowels, and a lot of people taking this drug will realize they can't stop taking it, otherwise the weight will come back. If I had weight issues, I would hesitate to try it too, because I've read some research articles about it that are quite disturbing!

Let's just say it's not the miracle drug people think it is. I hope your husband and sibling are very educated about it and know the limitations of their medication.

I totally disagree. I think it is a miracle drug. 75 percent of Americans are overweight. This drug helps tremendously, with relatively manageable side effects. To ignore that is so short sighted.

But people will argue vehemently that you can be fit and fat. Why are we suddenly rushing to use drugs to control weight if it doesn’t matter? Also, let’s see how these lab rats fare in a few years after continued use.

Come on, we know that’s wishful thinking. You can be fitter and fat. But not truly fit if you’re fat

Most pro football players have an obese BMI and yet could outrun most of DCUM. You can absolutely be a runner who lifts weight and is still obese. Would that person be even healthier at a lower weight? In many cases yes - better for joints - but often not healthier at the "healthy bmi" weight which is too low for certain people including many athletes.

Not beyond a sprint

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Your friend is probably very insecure about his own weight, and also anxious about trying this drug himself because he's in a position to read about the clinical trial dossiers and post-commercialization reports on severe side effects.

I have to say, as a biologist working in pharma, he's not wrong: some people have died due to complications from slow-moving bowels, and a lot of people taking this drug will realize they can't stop taking it, otherwise the weight will come back. If I had weight issues, I would hesitate to try it too, because I've read some research articles about it that are quite disturbing!

Let's just say it's not the miracle drug people think it is. I hope your husband and sibling are very educated about it and know the limitations of their medication.

I totally disagree. I think it is a miracle drug. 75 percent of Americans are overweight. This drug helps tremendously, with relatively manageable side effects. To ignore that is so short sighted.

NP

What’s truly short sighted is to use drugs to fix the *symptom* rather than address the underlying problem.

(i.e. why are 75 percent of Americans overweight in the first place?)

That is what is brilliant about GLP-1s -- they do address the underlying problem. Which is hormonal.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Your friend is probably very insecure about his own weight, and also anxious about trying this drug himself because he's in a position to read about the clinical trial dossiers and post-commercialization reports on severe side effects.

I have to say, as a biologist working in pharma, he's not wrong: some people have died due to complications from slow-moving bowels, and a lot of people taking this drug will realize they can't stop taking it, otherwise the weight will come back. If I had weight issues, I would hesitate to try it too, because I've read some research articles about it that are quite disturbing!

Let's just say it's not the miracle drug people think it is. I hope your husband and sibling are very educated about it and know the limitations of their medication.

I totally disagree. I think it is a miracle drug. 75 percent of Americans are overweight. This drug helps tremendously, with relatively manageable side effects. To ignore that is so short sighted.

NP

What’s truly short sighted is to use drugs to fix the *symptom* rather than address the underlying problem.

(i.e. why are 75 percent of Americans overweight in the first place?)

I don’t think any of us would disagree with that. But it will take a generation or more to accomplish. I’m living now and need a solution now. Having lost and regained 30-50 pounds 5 different times during my life, this medicine is giving me hope that I can hit a normal weight and cut back to a small maintenance dose and be healthy for the long term.

These drugs are essentially appetite suppressants? Is that right?

No. It's far more complex than that.

We've had medications that are just appetite suppressants for many years. They don't work anywhere near as well as GLP-1.

[Anonymous]

Anonymous wrote:

Anonymous wrote:Ozempic is not without risks. Specifically, it dramatically slows digestion, which can cause dangerous constipation that can lead to necrosis. It should be used with caution for anyone with a compromised GI system. This has been slow-rolled by the pharma companies and kind of buried.

I believe it has also been linked to thyroid cancer?

Yes, definitely increased probability of thyroid cancer, not to mention how it makes food just sit and putrefy in your stomach.

This can’t be sustainable, can it? How long should you go without pooping?

[Anonymous]

Nature is a high standard peer-reviewed scientific journal for scientists. This is new publication dated January 20, 2025. It’s on a paywall but essentially said ozempic and other GLP-1 drugs increase risks for pancreatitis by 146% and arthritis by 11%.

https://www.nature.com/articles/d41586-025-00173-5

[Anonymous]

I think that we’re only hitting the tip of the iceberg with the long term effects of glp-1 long term side effects. It would be interesting to see 10 years from now.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Your friend is probably very insecure about his own weight, and also anxious about trying this drug himself because he's in a position to read about the clinical trial dossiers and post-commercialization reports on severe side effects.

I have to say, as a biologist working in pharma, he's not wrong: some people have died due to complications from slow-moving bowels, and a lot of people taking this drug will realize they can't stop taking it, otherwise the weight will come back. If I had weight issues, I would hesitate to try it too, because I've read some research articles about it that are quite disturbing!

Let's just say it's not the miracle drug people think it is. I hope your husband and sibling are very educated about it and know the limitations of their medication.

I totally disagree. I think it is a miracle drug. 75 percent of Americans are overweight. This drug helps tremendously, with relatively manageable side effects. To ignore that is so short sighted.

NP

What’s truly short sighted is to use drugs to fix the *symptom* rather than address the underlying problem.

(i.e. why are 75 percent of Americans overweight in the first place?)

That is what is brilliant about GLP-1s -- they do address the underlying problem. Which is hormonal.

How can hormones be the underlying problem for most obese people in the US? I’m not saying it’s not an issue for many people, but if it were the primary cause, wouldn’t you say the same obesity levels in all other developed countries?

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Your friend is probably very insecure about his own weight, and also anxious about trying this drug himself because he's in a position to read about the clinical trial dossiers and post-commercialization reports on severe side effects.

I have to say, as a biologist working in pharma, he's not wrong: some people have died due to complications from slow-moving bowels, and a lot of people taking this drug will realize they can't stop taking it, otherwise the weight will come back. If I had weight issues, I would hesitate to try it too, because I've read some research articles about it that are quite disturbing!

Let's just say it's not the miracle drug people think it is. I hope your husband and sibling are very educated about it and know the limitations of their medication.

I totally disagree. I think it is a miracle drug. 75 percent of Americans are overweight. This drug helps tremendously, with relatively manageable side effects. To ignore that is so short sighted.

NP

What’s truly short sighted is to use drugs to fix the *symptom* rather than address the underlying problem.

(i.e. why are 75 percent of Americans overweight in the first place?)

That is what is brilliant about GLP-1s -- they do address the underlying problem. Which is hormonal.

How can hormones be the underlying problem for most obese people in the US? I’m not saying it’s not an issue for many people, but if it were the primary cause, wouldn’t you say the same obesity levels in all other developed countries?

*see

[Anonymous]

Anonymous wrote: Nature is a high standard peer-reviewed scientific journal for scientists. This is new publication dated January 20, 2025. It’s on a paywall but essentially said ozempic and other GLP-1 drugs increase risks for pancreatitis by 146% and arthritis by 11%.

https://www.nature.com/articles/d41586-025-00173-5

It’s a balance of risk. It reduces risk for other things. “GLP-1 drugs were linked to a lower risk of dozens of conditions, including heart disease, stroke and kidney disease. They also lowered the risk of psychotic disorders by 18%, Alzheimer’s disease by 12% and addiction disorders by an average of 13%” those things kill more people than pancreatitis or arthritis

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Ozempic is not without risks. Specifically, it dramatically slows digestion, which can cause dangerous constipation that can lead to necrosis. It should be used with caution for anyone with a compromised GI system. This has been slow-rolled by the pharma companies and kind of buried.

I believe it has also been linked to thyroid cancer?

Yes, definitely increased probability of thyroid cancer, not to mention how it makes food just sit and putrefy in your stomach.

This can’t be sustainable, can it? How long should you go without pooping?

Been on it for several years now. Go every day. No, food does not putrify in your stomach FFS. Stop with the idiotic, uneducated, uninformed horseshit comments.

[Anonymous]

Anonymous wrote: Nature is a high standard peer-reviewed scientific journal for scientists. This is new publication dated January 20, 2025. It’s on a paywall but essentially said ozempic and other GLP-1 drugs increase risks for pancreatitis by 146% and arthritis by 11%.

https://www.nature.com/articles/d41586-025-00173-5

We have all known this for as long as the drugs have been around. Being obese increases the risk of diabetes, heart disease and death, so.....

[Anonymous]

I have to agree with a previous OP. if the main issue in US is Glp-1 hormonal linked obesity, then why is it that obesity is so rampant and one of the highest rates in developed countries? That is the wider issue. I travelled to Europe and Asia, I have never seen so many obese compared to USA. So how has it become Glp-1 hormonal linked?