Friend who works in pharma went on a rant about how bad Ozempic etc is for people. ?

[Anonymous]

I have changed my views on these drugs. How realistic is it that someone over 100lbs overweight will lose this weight. Sure there are stories but these are outliers. Being obese is an illness

[Anonymous]

I could lose some weight. At this point I’m concerned about GLP1s because of known side effects, unknown/lesser known side effects that continue to emerge with further study, and the boomerang of weight gain when you stop taking it (even if you don’t consume a surplus of calories) which will essentially mean you are “hooked”. These aren’t irrational concerns.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Your friend is probably very insecure about his own weight, and also anxious about trying this drug himself because he's in a position to read about the clinical trial dossiers and post-commercialization reports on severe side effects.

I have to say, as a biologist working in pharma, he's not wrong: some people have died due to complications from slow-moving bowels, and a lot of people taking this drug will realize they can't stop taking it, otherwise the weight will come back. If I had weight issues, I would hesitate to try it too, because I've read some research articles about it that are quite disturbing!

Let's just say it's not the miracle drug people think it is. I hope your husband and sibling are very educated about it and know the limitations of their medication.

I totally disagree. I think it is a miracle drug. 75 percent of Americans are overweight. This drug helps tremendously, with relatively manageable side effects. To ignore that is so short sighted.

But people will argue vehemently that you can be fit and fat. Why are we suddenly rushing to use drugs to control weight if it doesn’t matter? Also, let’s see how these lab rats fare in a few years after continued use.

Not all people are the same.
You can be fit and fat.
Fat also increases some risks like diabetes.

Everyone including ops friend should myob

There is not a single objective health measure that improves by carrying excessive body fat other than being dramatically underweight. That's reality.

Reality is that you and the rest of the fatphobes on this forum/in this culture don't give a rat's behind about a fat stranger's health. Fat bodies are an acceptable target for your concern trolling, othering, and ableism. That's it. You hide behind "health concerns" but if you really gave a damn about a stranger's health, you wouldn't lead by insulting their intelligence, framing yourself as superior because you wear a smaller size, and then treating them like a hapless idiot who needs your help or your opinion.

Being judged for existing in the body you've got isn't good for anyone's health, doesn't motivate people to change their body shape, and can actively harm people to the point of suicidal ideation and self-harm.

There's not a single objective health measure that improves by being judged by a stranger. THAT is reality, so STFU.

You might consider that when you quote a post, the prior discussion was included.

If you bothered reading, you would find I was responding to the notion that fitness and being fat can coexist. That’s just not true. In extremely rare cases people with an obese BMI may not be carrying around significant body fat far in excess of what’s healthy. That’s not the 99.9% of Americans in the obese category. That’s what I was responding to that caused you to get all butt hurt.

So no, there is not a single objective health measure that improves by carrying around excess body fat. Maybe go work on that instead of being butt hurt by people pointing out facts. Facts aren’t judgement - you just turn them into something about you because you don’t like general facts. Maybe also work on that while you are at it.

I dont know.. I have a good v02max, low rhr, can jog a few miles, erg, exercise bike for an hour at high resistance, have pretty good balance and reflexes, but per the BMI I am obese. And sure, I have extra weight but I am in pretty good shape. And, no matter how much I exercise, I can’t get below a floor for weight loss. I’m in my 40s and my physical fitness hasn’t prevented me from physical activities I want to do. I bike, ski, hike, etc.

I think there’s a lot researchers still dont understand about weight gain/loss and how it all works.

[Anonymous]

Anonymous wrote:

Anonymous wrote:self-control. People like people that have self-control and self-regulation.

This. I am embarrased for anyone using these drugs for weightloss. How about you learn to exercise and not stuff your mouth full of processed garbage?

Because some people are genetically predisposed to being fatter or having bigger body types. Unfortunately, we are forced to believe that weight loss is easy for EVERYONE and it's this one size fits all, cookie cutter remedy of cutting calories and increasing activity. This is not possible for some people because I'm order for their body to function optimally, they need to eat and not starve themselves. But nooo, we live in a world that tells us all that we have to be thin. They end up doing that by any means even if it compromises their health and well being. Thin above all else, right? Looking healthy trumps actual health measures at this point.

[Anonymous]

Anonymous wrote:

Anonymous wrote:self-control. People like people that have self-control and self-regulation.

This. I am embarrased for anyone using these drugs for weightloss. How about you learn to exercise and not stuff your mouth full of processed garbage?

I don't care that you're embarrassed for me or that you don't like me. But I know many people share your ideas so I only tell people I trust that I'm taking it when they notice my weight loss.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:self-control. People like people that have self-control and self-regulation.

This. I am embarrased for anyone using these drugs for weightloss. How about you learn to exercise and not stuff your mouth full of processed garbage?

Because some people are genetically predisposed to being fatter or having bigger body types. Unfortunately, we are forced to believe that weight loss is easy for EVERYONE and it's this one size fits all, cookie cutter remedy of cutting calories and increasing activity. This is not possible for some people because I'm order for their body to function optimally, they need to eat and not starve themselves. But nooo, we live in a world that tells us all that we have to be thin. They end up doing that by any means even if it compromises their health and well being. Thin above all else, right? Looking healthy trumps actual health measures at this point.

Yeah. And while obesity is highly correlated with poor health outcomes, it’s frequently misunderstood if x is correlated with y than x means y will happen. There are a million variables. For example, not everyone who worked their entire lives exposed to asbestos got mesothelioma.


Further, someone with a high BMI who eats a healthy diet and exercises 3hrs a week is more healthy than someone with a low BMI who eats garbage and is sedentary.

[Anonymous]

Anonymous wrote:

Anonymous wrote:self-control. People like people that have self-control and self-regulation.

This. I am embarrased for anyone using these drugs for weightloss. How about you learn to exercise and not stuff your mouth full of processed garbage?

What an ugly person you are.

No drug can cure that!

[Anonymous]

Anonymous wrote:Ozempic is not without risks. Specifically, it dramatically slows digestion, which can cause dangerous constipation that can lead to necrosis. It should be used with caution for anyone with a compromised GI system. This has been slow-rolled by the pharma companies and kind of buried.

I believe it has also been linked to thyroid cancer?

[Anonymous]

Anonymous wrote:self-control. People like people that have self-control and self-regulation.

Aren't you a nasty little b___. People like this have bodies that work normally. They cannot fathom that someone's body doesn't work the same way as theirs and they might need medication to help regulate hormones and other chemicals within their body to help.

[Anonymous]

Anonymous wrote:

Anonymous wrote:self-control. People like people that have self-control and self-regulation.

This. I am embarrased for anyone using these drugs for weightloss. How about you learn to exercise and not stuff your mouth full of processed garbage?

I am embarrassed for anyone who is as stupid as you!

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Your friend is probably very insecure about his own weight, and also anxious about trying this drug himself because he's in a position to read about the clinical trial dossiers and post-commercialization reports on severe side effects.

I have to say, as a biologist working in pharma, he's not wrong: some people have died due to complications from slow-moving bowels, and a lot of people taking this drug will realize they can't stop taking it, otherwise the weight will come back. If I had weight issues, I would hesitate to try it too, because I've read some research articles about it that are quite disturbing!

Let's just say it's not the miracle drug people think it is. I hope your husband and sibling are very educated about it and know the limitations of their medication.

I totally disagree. I think it is a miracle drug. 75 percent of Americans are overweight. This drug helps tremendously, with relatively manageable side effects. To ignore that is so short sighted.

NP

What’s truly short sighted is to use drugs to fix the *symptom* rather than address the underlying problem.

(i.e. why are 75 percent of Americans overweight in the first place?)

I don’t think any of us would disagree with that. But it will take a generation or more to accomplish. I’m living now and need a solution now. Having lost and regained 30-50 pounds 5 different times during my life, this medicine is giving me hope that I can hit a normal weight and cut back to a small maintenance dose and be healthy for the long term.

These drugs are essentially appetite suppressants? Is that right?

It’s not that. It does something to the inflammatory response and one side effect is appetite suppression, but it’s more than that. My close friend who went on it had her lifelong severe rosacea clear up within a month of starting, before any serious weight was lost. Her dermatologist told her that she’s seeing the same thing with other patients.

I don’t know what is going on but weight is just one piece of the puzzle here.

I find it troubling that we don’t really understand the drug’s mechanism and consequences, but people who feel bad about their appearance are just asking, “where do I sign up?”

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Your friend is probably very insecure about his own weight, and also anxious about trying this drug himself because he's in a position to read about the clinical trial dossiers and post-commercialization reports on severe side effects.

I have to say, as a biologist working in pharma, he's not wrong: some people have died due to complications from slow-moving bowels, and a lot of people taking this drug will realize they can't stop taking it, otherwise the weight will come back. If I had weight issues, I would hesitate to try it too, because I've read some research articles about it that are quite disturbing!

Let's just say it's not the miracle drug people think it is. I hope your husband and sibling are very educated about it and know the limitations of their medication.

I totally disagree. I think it is a miracle drug. 75 percent of Americans are overweight. This drug helps tremendously, with relatively manageable side effects. To ignore that is so short sighted.

But people will argue vehemently that you can be fit and fat. Why are we suddenly rushing to use drugs to control weight if it doesn’t matter? Also, let’s see how these lab rats fare in a few years after continued use.

You do know it has been studied in lab rats for years, right? It was used for diabetes control

Then why does the scientific community keep being surprised about its impact? Believe me, the drug companies would have been marketing these newly revealed benefits, if they had been known.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Your friend is probably very insecure about his own weight, and also anxious about trying this drug himself because he's in a position to read about the clinical trial dossiers and post-commercialization reports on severe side effects.

I have to say, as a biologist working in pharma, he's not wrong: some people have died due to complications from slow-moving bowels, and a lot of people taking this drug will realize they can't stop taking it, otherwise the weight will come back. If I had weight issues, I would hesitate to try it too, because I've read some research articles about it that are quite disturbing!

Let's just say it's not the miracle drug people think it is. I hope your husband and sibling are very educated about it and know the limitations of their medication.

I totally disagree. I think it is a miracle drug. 75 percent of Americans are overweight. This drug helps tremendously, with relatively manageable side effects. To ignore that is so short sighted.

NP

What’s truly short sighted is to use drugs to fix the *symptom* rather than address the underlying problem.

(i.e. why are 75 percent of Americans overweight in the first place?)

I don’t think any of us would disagree with that. But it will take a generation or more to accomplish. I’m living now and need a solution now. Having lost and regained 30-50 pounds 5 different times during my life, this medicine is giving me hope that I can hit a normal weight and cut back to a small maintenance dose and be healthy for the long term.

These drugs are essentially appetite suppressants? Is that right?

It’s not that. It does something to the inflammatory response and one side effect is appetite suppression, but it’s more than that. My close friend who went on it had her lifelong severe rosacea clear up within a month of starting, before any serious weight was lost. Her dermatologist told her that she’s seeing the same thing with other patients.

I don’t know what is going on but weight is just one piece of the puzzle here.

I find it troubling that we don’t really understand the drug’s mechanism and consequences, but people who feel bad about their appearance are just asking, “where do I sign up?”

Let’s not be so naive. They just don’t want to alarm us with the facts.

[Anonymous]

Anonymous wrote:Your friend is probably very insecure about his own weight, and also anxious about trying this drug himself because he's in a position to read about the clinical trial dossiers and post-commercialization reports on severe side effects.

I have to say, as a biologist working in pharma, he's not wrong: some people have died due to complications from slow-moving bowels, and a lot of people taking this drug will realize they can't stop taking it, otherwise the weight will come back. If I had weight issues, I would hesitate to try it too, because I've read some research articles about it that are quite disturbing!

Let's just say it's not the miracle drug people think it is. I hope your husband and sibling are very educated about it and know the limitations of their medication.

Am learning that Ozempic makes food stay in your stomach. This is why you feel full. But this eventually results in “backed up” digestion problems. How does anyone expect anything else?

[Anonymous]

Anonymous wrote:

Anonymous wrote:But unfortunately many people don’t, can’t etc.



My dh has diabetes. My sibling some other health related issues that have put him on meds that make weight loss hard.

Both are on it for medical reasons.

I think it's awful for people that don't have a medical need for it. People with a medical need should absolutely use it if they need to with no shame. The people who use it for vanity purposes to lose 20 lbs are lazy and deserve to be shamed. And have all the nasty side effects that come with it.

Misplaced rage that should probably be addressed in therapy ^^