Miscarriage of PGS normal
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Anonymous
| I'm sure this has been discussed before, but I can't find the threads and I'm in shock. Transferred one PGS normal, had great betas, saw heart beat at 6 week u/s, and now at 8 weeks 6 days no heartbeat. No bleeding and no cramping. Now waiting to get in for a D&C. I was foolishly complacent - lulled by the PGS testing and especially the heartbeat. This was my first transfer, first pregnancy, first loss... I have 2 other PGS normals on ice but I'm 41 and don't want to waste them. What now? Immune testing? Is there a chance this was just a fluke and the next one could work? |
Anonymous
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Make sure they do microarray genetic testing on the tissue sample retrieved at D&C. I've gone though a similar experience and it turns out that PGS does not test for mosaicism, so "normal" means "normalish" - no deletions or extra chromosomes, but could be other issues that are not detectable by PGS.
Immune testing can't hurt, also, were you on progesterone shots still when this happened? |
Anonymous
I'm so sorry OP 
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Anonymous
+1 |
Anonymous
| Microarray CGH doesn't detect mosaics - next generation sequencing does. I did testing in 2013 that was a-CGH and then now in 2017 my clinic is doing NGS and they told me some embryos that could be CGH normal may not be next gen normal |
Anonymous
| there is statistically a small % of PGS normal embryos that miscarry - it's way lower than the normal amount. but it's not 0. maybe just BAD luck. so sorry OP |
Anonymous
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are you this poster, OP:
http://www.dcurbanmom.com/jforum/posts/list/634881.page |
Anonymous
| Wow! I thought PGS tested embryo is a sure win. I'm considering this and I'm not so sure now. (Due to financial reasons). I'm so sorry, OP! |
Anonymous
"sure win"- it's about a 60% chance of success. |
Anonymous
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This is OP, no I'm not that poster. My RE was very clear, no heart beat and game over. I've been on PIO shots and the nurse actually told me to stay on them so I don't start MC on my own. I had no clue about PGS tested not being a gold standard. I mean I'm sure I knew that somewhere but must have just lulled myself into a false sense of security. |
Anonymous
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OP, I'm so sorry. I also transferred a PGS normal embryo last month and, and had done extensive immune testing.
Although my betas were great, it ended up as a blighted ovum (empty gestational sac). I also thought I PGS was a sure bet, but now I'm reading that it can miss a number of chromosomal abnormalities. A big hug to you. |
Anonymous
| I'm 38 and had a healthy pregnancy - but my IVF doctor told me at my age (37 at the time) about 25% of naturally occurring pregnancies result in miscarriage and about 4% of PGS tested embryos. Sorry for your loss OP. |
Anonymous
So you're telling OP she's in the 4% then? |
Anonymous
euploid embryos *ARE* the gold standard in IVF in that they're much more likely to implant, and less likely to miscarry. But they don't all implant- it's still only at best 65% success rate, and there is still a small - I guess 5% - chance of miscarriage. |
Anonymous
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I'm really sorry this happened to you.
I had a pregnancy that was chromosomally abnormal that went to 11 weeks (so had several scans with heartbeats) and I am told it would not have been caught by PGS. This was a triploid pregnancy, meaning that it had 69 chromosomes instead of 46. I was told that PGS testing looks for balance and can only see extra or missing chromosomes at particular locations, but not when there is an extra chromosome at all 23 locations because there is balance throughout. Definitely have the fetal tissue genetically tested even though it was PGS tested. They can tell you then what exactly was going on. If all was normal, I would look into immune issues just to cover your bases. |