Anonymous wrote:
Anonymous wrote:
Anonymous wrote:Have you tried Winlevi? It is topical and new in the last few months. It cleared up DDs skin in two weeks.
This is hormonal so they will only prescribe it to females.
NOT TRUE. It stops the hormonal production on the SURFACE of the skin so it can be used by males unlike oral spironolactone.
Winlevi is an androgen receptor inhibitor meant to treat acne vulgaris in both males and females. The drug is a topical cream and should be available early next year. Dermatologists may use Winlevi in combination with other treatments to meet individual needs.
Winlevi is the first to use a totally new active: 1% clascoterone. Clascoterone is a topical androgen receptor inhibitor, meaning it inhibits testosterone and dihydrotestosterone (DHT) when applied to skin.
The ingredient is also used for the treatment of hair loss on the scalp.
Androgens in your skin are responsible for the production of sebum (oil) and can lead to inflammation, which exacerbates acne. Cassiopea, the pharmaceutical company behind Winlevi, notes that while the exact mechanism behind how clascoterone works is unknown, the cream was proven to reduce acne lesions in clinical trials in both men and women over the age of 12.
What makes clascoterone such a breakthrough is that it's the first androgen blocker for acne that works in both men and women. Women are often prescribed birth control pills and spironolactone pills (off-label) to reduce androgen activity and help with acne breakouts. But as a 2020 study in JAMA Dermatology points out: "Both [birth control] and spironolactone are associated with systemic adverse effects, are contraindicated in pregnancy, and are unsuitable for use in males with acne."
The study concludes that not only is clascoterone safe and effective for both men and women, but it can also be used as an adjunct treatment with other acne medications like retinoids.