"I No Longer Think GLP-1s Are the Answer — The drugs "work" but may be working against us long-term"

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

There is no proven way to lose weight without a very high likelihood of yoyo weight.

So let's choose the option that's free and has the same result.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

There is no proven way to lose weight without a very high likelihood of yoyo weight.

So let's choose the option that's free and has the same result.

Go for it! I’m choosing the option that cost me 25 dollars a month and actually works , whereas the last 20 years of dirt and exercise and thinking of food constantly has not. For me. We both win!

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:His claim that people who use the drugs lose muscle and don’t gain it back when they stop the drug therapy is concerning.

Has only to do with the speed of weight loss, which can be managed with proper dosing and nutrient intake. The issue is not with the medication.

In theory, yes. In practice, no. I’ve never seen anyone not lose massive amounts of muscle. Sure, it’s possible but it’s just as hard as losing weight and building muscle in a lifelong way - so the old fashioned way is better/safer.

Everyone loses muscle when they lose weight. You can reduce muscle mass loss by lifting and losing at a 1-2 lb per week rate. Nothing to do with the GLP-1…

You are naive and will fight to the end. Continue on your path.

GLP has everything to do with rate, which is what causes the large muscle loss. Gradual lifestyle changes are far more sustainable and healthier on your body.

Sure come back and say they’re not. I really don’t care. Then again I don’t need GLPs. I’m an athlete with a long history of muscle building and lifestyle sustainability. So just like you think popping a pill is magic with no long term data - I think healthy diet and exercise is magic with long term data and sustainability.

Do you have any citations? Because I do. There’s no evidence that muscle mass loss in GLP-1s is any worse than muscle mass loss from other means.

“There's concern in the general public about how weight loss drugs affect muscle mass, but the presenters emphasize that the data doesn't show GLP-1 analogs have a unique, high level of lean body mass loss compared to other weight loss paradigms.”

https://advances.massgeneral.org/endocrinology/article.aspx?id=1601

I trust Mass General a lot more than I trust an unsubstantiated, anonymous claim on the internet.

Seriously?! You want citations for something so well known it dates back 100s of years of conventional wisdom? You are one of those “dumb” people PP mentioned.

Citations won’t convince me. We haven’t had these drugs long enough to even have the data. Remember the miracle drug fen-phen - this is the same. It’s a miracle until it’s not and we see the long term damage. The FDA approved fen-phen and the hype was the same as it is now. Maybe you are too young to remember that.

I should mention I’m in my 50s so I’ve seen the hype before. I’m also knowingly very bias. I’m 5’3” and 130 lbs - although I wear a size 0-2 - so I’m solid muscle, like really solid.

We have a couple decades of data but you don’t want to believe it because it makes you mad.

Same with fen-phen. And as I said - I don’t care what you do to your individual body. You could take prescription Adderall or non prescription speed and get the same effect - I also don’t want those normalized in society, just as this drug shouldn’t be normalized. I also don’t believe in normalizing pot, lsd, oxy, coke, fentanyl - most of which were legal at some point in history - and there is a reason they are no longer legal.

You've made too many stupid comments to catalog in this thread (and I'm only halfway through it) but "fentanyl is illegal" is so idiotic it is worth calling out. Same for OxyContin.

Is it though? Oxy - heroin - fentanyl is a well established pattern. It’s even in Revenge of the Tipping Point, but you’d have to be able to read above 5th grade level to get that reference.

Nice diversion, or attempt, at least. Oxy and fentanyl are not illegal, though. What made you claim otherwise?

Nice diversion. I didn’t claim they were.

Scroll up. “There is a reason they are no longer legal”.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

There is no proven way to lose weight without a very high likelihood of yoyo weight.

So let's choose the option that's free and has the same result.

Go for it! I’m choosing the option that cost me 25 dollars a month and actually works , whereas the last 20 years of dirt and exercise and thinking of food constantly has not. For me. We both win!

I'm glad it works for you. But a drug that the majority of people do not use as intended is not a particularly effective drug.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:His claim that people who use the drugs lose muscle and don’t gain it back when they stop the drug therapy is concerning.

Has only to do with the speed of weight loss, which can be managed with proper dosing and nutrient intake. The issue is not with the medication.

In theory, yes. In practice, no. I’ve never seen anyone not lose massive amounts of muscle. Sure, it’s possible but it’s just as hard as losing weight and building muscle in a lifelong way - so the old fashioned way is better/safer.

Everyone loses muscle when they lose weight. You can reduce muscle mass loss by lifting and losing at a 1-2 lb per week rate. Nothing to do with the GLP-1…

You are naive and will fight to the end. Continue on your path.

GLP has everything to do with rate, which is what causes the large muscle loss. Gradual lifestyle changes are far more sustainable and healthier on your body.

Sure come back and say they’re not. I really don’t care. Then again I don’t need GLPs. I’m an athlete with a long history of muscle building and lifestyle sustainability. So just like you think popping a pill is magic with no long term data - I think healthy diet and exercise is magic with long term data and sustainability.

Do you have any citations? Because I do. There’s no evidence that muscle mass loss in GLP-1s is any worse than muscle mass loss from other means.

“There's concern in the general public about how weight loss drugs affect muscle mass, but the presenters emphasize that the data doesn't show GLP-1 analogs have a unique, high level of lean body mass loss compared to other weight loss paradigms.”

https://advances.massgeneral.org/endocrinology/article.aspx?id=1601

I trust Mass General a lot more than I trust an unsubstantiated, anonymous claim on the internet.

Seriously?! You want citations for something so well known it dates back 100s of years of conventional wisdom? You are one of those “dumb” people PP mentioned.

Citations won’t convince me. We haven’t had these drugs long enough to even have the data. Remember the miracle drug fen-phen - this is the same. It’s a miracle until it’s not and we see the long term damage. The FDA approved fen-phen and the hype was the same as it is now. Maybe you are too young to remember that.

I should mention I’m in my 50s so I’ve seen the hype before. I’m also knowingly very bias. I’m 5’3” and 130 lbs - although I wear a size 0-2 - so I’m solid muscle, like really solid.

We have a couple decades of data but you don’t want to believe it because it makes you mad.

Same with fen-phen. And as I said - I don’t care what you do to your individual body. You could take prescription Adderall or non prescription speed and get the same effect - I also don’t want those normalized in society, just as this drug shouldn’t be normalized. I also don’t believe in normalizing pot, lsd, oxy, coke, fentanyl - most of which were legal at some point in history - and there is a reason they are no longer legal.

You've made too many stupid comments to catalog in this thread (and I'm only halfway through it) but "fentanyl is illegal" is so idiotic it is worth calling out. Same for OxyContin.

Is it though? Oxy - heroin - fentanyl is a well established pattern. It’s even in Revenge of the Tipping Point, but you’d have to be able to read above 5th grade level to get that reference.

Nice diversion, or attempt, at least. Oxy and fentanyl are not illegal, though. What made you claim otherwise?

Nice diversion. I didn’t claim they were.

Sigh.

Earlier in this thread, someone wrote:

I also don’t believe in normalizing pot, lsd, oxy, coke, fentanyl - most of which were legal at some point in history - and there is a reason they are no longer legal.

If that was you, you are an idiot.

If that wasn't you, you responded to my comment as if you were the author. But regardless, when I wrote that it was idiotic to claim that fentanyl and Oxy are illegal, you responded, "Is it though?"

To answer your question directly, yes, it is. Because they are not illegal. So we have established that the initial PP is an idiot, and you, in defending him or her, also is an idiot.

I am happy to have cleared that up for you.

Sigh. . . And you’re a childish name caller who can’t deal when people disagree with you.

I mean you can’t really “disagree” about whether or not a medication is legal or not. Unless you’re one of those alternative truth people.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

There is no proven way to lose weight without a very high likelihood of yoyo weight.

So let's choose the option that's free and has the same result.

Go for it! I’m choosing the option that cost me 25 dollars a month and actually works , whereas the last 20 years of dirt and exercise and thinking of food constantly has not. For me. We both win!

I'm glad it works for you. But a drug that the majority of people do not use as intended is not a particularly effective drug.

No, that’s not how effectiveness is measured. But do you have data to back up your claim?

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

There is no proven way to lose weight without a very high likelihood of yoyo weight.

So let's choose the option that's free and has the same result.

Go for it! I’m choosing the option that cost me 25 dollars a month and actually works , whereas the last 20 years of dirt and exercise and thinking of food constantly has not. For me. We both win!

I'm glad it works for you. But a drug that the majority of people do not use as intended is not a particularly effective drug.

I’m glad it works for me too! Most drugs aren’t effective if not used as intended/ prescribed. It’s tough for people to follow medication directions. I have actually read articles to help my patients with medication regimen adherence - things like not prescribing liquids, showing a picture of what you’re supposed to take, etc. The average American messes up medication a LOT. So anyways, yeah! Use as prescribed , it works very well for most people. Use not as prescribed- such as stopping taking it- and the effects are lost. A lot of meds work that way- insulin for example, or synthroid, or blood pressure meds- for you to benefit from them, you do need to continue to take them.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

Public school system? Hows that?

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

Public school system? Hows that?

Because they provide health insurance for their employees and are self-insured which means they just pay the cost of all the claims themselves.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

Public school system? Hows that?

Because they provide health insurance for their employees and are self-insured which means they just pay the cost of all the claims themselves.

So teachers are obese but you don't want them to get the meds needed to lose weight because it costs too much? Maybe the issue is with manufacturers and drug prices, but we all pay for very costly meds for all sorts of people including meds that are needed due to lifestyle issues.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

Public school system? Hows that?

Because they provide health insurance for their employees and are self-insured which means they just pay the cost of all the claims themselves.

So teachers are obese but you don't want them to get the meds needed to lose weight because it costs too much? Maybe the issue is with manufacturers and drug prices, but we all pay for very costly meds for all sorts of people including meds that are needed due to lifestyle issues.

Also the easy solution to prevent the “yo yo dieting” is to simply not drop coverage of them? Then insureds will keep the weight off?

[Anonymous]

After being a size 4 from teens into my late 40s,I was on a strict whole 30 and weight watchers diet simultaneously and was still gaining 20-30 lbs a year after i went through menopause and had some other metabolic issues almost reaching 200 lbs - glp-1s have been great for me and I am very open about being on them to try to counter the judgement on this thread. If diet and exercise alone work for you great - but mind your own business re: others

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

Public school system? Hows that?

Because they provide health insurance for their employees and are self-insured which means they just pay the cost of all the claims themselves.

So teachers are obese but you don't want them to get the meds needed to lose weight because it costs too much? Maybe the issue is with manufacturers and drug prices, but we all pay for very costly meds for all sorts of people including meds that are needed due to lifestyle issues.

If they aren't staying on the meds (apparently three quarters of people do not) we are spending millions to not improve their health, millions that could be spent to improve their working conditions.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

Public school system? Hows that?

Because they provide health insurance for their employees and are self-insured which means they just pay the cost of all the claims themselves.

So teachers are obese but you don't want them to get the meds needed to lose weight because it costs too much? Maybe the issue is with manufacturers and drug prices, but we all pay for very costly meds for all sorts of people including meds that are needed due to lifestyle issues.

Also the easy solution to prevent the “yo yo dieting” is to simply not drop coverage of them? Then insureds will keep the weight off?

Why spend money on something that doesn't improve people's health?

[Anonymous]

Anonymous wrote:After being a size 4 from teens into my late 40s,I was on a strict whole 30 and weight watchers diet simultaneously and was still gaining 20-30 lbs a year after i went through menopause and had some other metabolic issues almost reaching 200 lbs - glp-1s have been great for me and I am very open about being on them to try to counter the judgement on this thread. If diet and exercise alone work for you great - but mind your own business re: others

I have no judgement for anyone that uses a GLP-1 but I do not want to spend tax dollars or pay increased premiums to enrich big pharma when it doesn't improve health for three quarters of people that use the drugs.