"I No Longer Think GLP-1s Are the Answer — The drugs "work" but may be working against us long-term"

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:His claim that people who use the drugs lose muscle and don’t gain it back when they stop the drug therapy is concerning.

Has only to do with the speed of weight loss, which can be managed with proper dosing and nutrient intake. The issue is not with the medication.

In theory, yes. In practice, no. I’ve never seen anyone not lose massive amounts of muscle. Sure, it’s possible but it’s just as hard as losing weight and building muscle in a lifelong way - so the old fashioned way is better/safer.

Everyone loses muscle when they lose weight. You can reduce muscle mass loss by lifting and losing at a 1-2 lb per week rate. Nothing to do with the GLP-1…

You are naive and will fight to the end. Continue on your path.

GLP has everything to do with rate, which is what causes the large muscle loss. Gradual lifestyle changes are far more sustainable and healthier on your body.

Sure come back and say they’re not. I really don’t care. Then again I don’t need GLPs. I’m an athlete with a long history of muscle building and lifestyle sustainability. So just like you think popping a pill is magic with no long term data - I think healthy diet and exercise is magic with long term data and sustainability.

Do you have any citations? Because I do. There’s no evidence that muscle mass loss in GLP-1s is any worse than muscle mass loss from other means.

“There's concern in the general public about how weight loss drugs affect muscle mass, but the presenters emphasize that the data doesn't show GLP-1 analogs have a unique, high level of lean body mass loss compared to other weight loss paradigms.”

https://advances.massgeneral.org/endocrinology/article.aspx?id=1601

I trust Mass General a lot more than I trust an unsubstantiated, anonymous claim on the internet.

Seriously?! You want citations for something so well known it dates back 100s of years of conventional wisdom? You are one of those “dumb” people PP mentioned.

Citations won’t convince me. We haven’t had these drugs long enough to even have the data. Remember the miracle drug fen-phen - this is the same. It’s a miracle until it’s not and we see the long term damage. The FDA approved fen-phen and the hype was the same as it is now. Maybe you are too young to remember that.

I should mention I’m in my 50s so I’ve seen the hype before. I’m also knowingly very bias. I’m 5’3” and 130 lbs - although I wear a size 0-2 - so I’m solid muscle, like really solid.

We have a couple decades of data but you don’t want to believe it because it makes you mad.

Same with fen-phen. And as I said - I don’t care what you do to your individual body. You could take prescription Adderall or non prescription speed and get the same effect - I also don’t want those normalized in society, just as this drug shouldn’t be normalized. I also don’t believe in normalizing pot, lsd, oxy, coke, fentanyl - most of which were legal at some point in history - and there is a reason they are no longer legal.

You've made too many stupid comments to catalog in this thread (and I'm only halfway through it) but "fentanyl is illegal" is so idiotic it is worth calling out. Same for OxyContin.

Is it though? Oxy - heroin - fentanyl is a well established pattern. It’s even in Revenge of the Tipping Point, but you’d have to be able to read above 5th grade level to get that reference.

Nice diversion, or attempt, at least. Oxy and fentanyl are not illegal, though. What made you claim otherwise?

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:His claim that people who use the drugs lose muscle and don’t gain it back when they stop the drug therapy is concerning.

Has only to do with the speed of weight loss, which can be managed with proper dosing and nutrient intake. The issue is not with the medication.

In theory, yes. In practice, no. I’ve never seen anyone not lose massive amounts of muscle. Sure, it’s possible but it’s just as hard as losing weight and building muscle in a lifelong way - so the old fashioned way is better/safer.

Everyone loses muscle when they lose weight. You can reduce muscle mass loss by lifting and losing at a 1-2 lb per week rate. Nothing to do with the GLP-1…

You are naive and will fight to the end. Continue on your path.

GLP has everything to do with rate, which is what causes the large muscle loss. Gradual lifestyle changes are far more sustainable and healthier on your body.

Sure come back and say they’re not. I really don’t care. Then again I don’t need GLPs. I’m an athlete with a long history of muscle building and lifestyle sustainability. So just like you think popping a pill is magic with no long term data - I think healthy diet and exercise is magic with long term data and sustainability.

Do you have any citations? Because I do. There’s no evidence that muscle mass loss in GLP-1s is any worse than muscle mass loss from other means.

“There's concern in the general public about how weight loss drugs affect muscle mass, but the presenters emphasize that the data doesn't show GLP-1 analogs have a unique, high level of lean body mass loss compared to other weight loss paradigms.”

https://advances.massgeneral.org/endocrinology/article.aspx?id=1601

I trust Mass General a lot more than I trust an unsubstantiated, anonymous claim on the internet.

Seriously?! You want citations for something so well known it dates back 100s of years of conventional wisdom? You are one of those “dumb” people PP mentioned.

Citations won’t convince me. We haven’t had these drugs long enough to even have the data. Remember the miracle drug fen-phen - this is the same. It’s a miracle until it’s not and we see the long term damage. The FDA approved fen-phen and the hype was the same as it is now. Maybe you are too young to remember that.

I should mention I’m in my 50s so I’ve seen the hype before. I’m also knowingly very bias. I’m 5’3” and 130 lbs - although I wear a size 0-2 - so I’m solid muscle, like really solid.

We have a couple decades of data but you don’t want to believe it because it makes you mad.

Same with fen-phen. And as I said - I don’t care what you do to your individual body. You could take prescription Adderall or non prescription speed and get the same effect - I also don’t want those normalized in society, just as this drug shouldn’t be normalized. I also don’t believe in normalizing pot, lsd, oxy, coke, fentanyl - most of which were legal at some point in history - and there is a reason they are no longer legal.

You've made too many stupid comments to catalog in this thread (and I'm only halfway through it) but "fentanyl is illegal" is so idiotic it is worth calling out. Same for OxyContin.

Is it though? Oxy - heroin - fentanyl is a well established pattern. It’s even in Revenge of the Tipping Point, but you’d have to be able to read above 5th grade level to get that reference.

Nice diversion, or attempt, at least. Oxy and fentanyl are not illegal, though. What made you claim otherwise?

Nice diversion. I didn’t claim they were.

[Anonymous]

It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:His claim that people who use the drugs lose muscle and don’t gain it back when they stop the drug therapy is concerning.

Has only to do with the speed of weight loss, which can be managed with proper dosing and nutrient intake. The issue is not with the medication.

In theory, yes. In practice, no. I’ve never seen anyone not lose massive amounts of muscle. Sure, it’s possible but it’s just as hard as losing weight and building muscle in a lifelong way - so the old fashioned way is better/safer.

Everyone loses muscle when they lose weight. You can reduce muscle mass loss by lifting and losing at a 1-2 lb per week rate. Nothing to do with the GLP-1…

You are naive and will fight to the end. Continue on your path.

GLP has everything to do with rate, which is what causes the large muscle loss. Gradual lifestyle changes are far more sustainable and healthier on your body.

Sure come back and say they’re not. I really don’t care. Then again I don’t need GLPs. I’m an athlete with a long history of muscle building and lifestyle sustainability. So just like you think popping a pill is magic with no long term data - I think healthy diet and exercise is magic with long term data and sustainability.

Do you have any citations? Because I do. There’s no evidence that muscle mass loss in GLP-1s is any worse than muscle mass loss from other means.

“There's concern in the general public about how weight loss drugs affect muscle mass, but the presenters emphasize that the data doesn't show GLP-1 analogs have a unique, high level of lean body mass loss compared to other weight loss paradigms.”

https://advances.massgeneral.org/endocrinology/article.aspx?id=1601

I trust Mass General a lot more than I trust an unsubstantiated, anonymous claim on the internet.

Seriously?! You want citations for something so well known it dates back 100s of years of conventional wisdom? You are one of those “dumb” people PP mentioned.

Citations won’t convince me. We haven’t had these drugs long enough to even have the data. Remember the miracle drug fen-phen - this is the same. It’s a miracle until it’s not and we see the long term damage. The FDA approved fen-phen and the hype was the same as it is now. Maybe you are too young to remember that.

I should mention I’m in my 50s so I’ve seen the hype before. I’m also knowingly very bias. I’m 5’3” and 130 lbs - although I wear a size 0-2 - so I’m solid muscle, like really solid.

We have a couple decades of data but you don’t want to believe it because it makes you mad.

Same with fen-phen. And as I said - I don’t care what you do to your individual body. You could take prescription Adderall or non prescription speed and get the same effect - I also don’t want those normalized in society, just as this drug shouldn’t be normalized. I also don’t believe in normalizing pot, lsd, oxy, coke, fentanyl - most of which were legal at some point in history - and there is a reason they are no longer legal.

You've made too many stupid comments to catalog in this thread (and I'm only halfway through it) but "fentanyl is illegal" is so idiotic it is worth calling out. Same for OxyContin.

Is it though? Oxy - heroin - fentanyl is a well established pattern. It’s even in Revenge of the Tipping Point, but you’d have to be able to read above 5th grade level to get that reference.

Nice diversion, or attempt, at least. Oxy and fentanyl are not illegal, though. What made you claim otherwise?

Nice diversion. I didn’t claim they were.

Sigh.

Earlier in this thread, someone wrote:

I also don’t believe in normalizing pot, lsd, oxy, coke, fentanyl - most of which were legal at some point in history - and there is a reason they are no longer legal.

If that was you, you are an idiot.

If that wasn't you, you responded to my comment as if you were the author. But regardless, when I wrote that it was idiotic to claim that fentanyl and Oxy are illegal, you responded, "Is it though?"

To answer your question directly, yes, it is. Because they are not illegal. So we have established that the initial PP is an idiot, and you, in defending him or her, also is an idiot.

I am happy to have cleared that up for you.

[Anonymous]

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:His claim that people who use the drugs lose muscle and don’t gain it back when they stop the drug therapy is concerning.

Has only to do with the speed of weight loss, which can be managed with proper dosing and nutrient intake. The issue is not with the medication.

In theory, yes. In practice, no. I’ve never seen anyone not lose massive amounts of muscle. Sure, it’s possible but it’s just as hard as losing weight and building muscle in a lifelong way - so the old fashioned way is better/safer.

Everyone loses muscle when they lose weight. You can reduce muscle mass loss by lifting and losing at a 1-2 lb per week rate. Nothing to do with the GLP-1…

You are naive and will fight to the end. Continue on your path.

GLP has everything to do with rate, which is what causes the large muscle loss. Gradual lifestyle changes are far more sustainable and healthier on your body.

Sure come back and say they’re not. I really don’t care. Then again I don’t need GLPs. I’m an athlete with a long history of muscle building and lifestyle sustainability. So just like you think popping a pill is magic with no long term data - I think healthy diet and exercise is magic with long term data and sustainability.

Do you have any citations? Because I do. There’s no evidence that muscle mass loss in GLP-1s is any worse than muscle mass loss from other means.

“There's concern in the general public about how weight loss drugs affect muscle mass, but the presenters emphasize that the data doesn't show GLP-1 analogs have a unique, high level of lean body mass loss compared to other weight loss paradigms.”

https://advances.massgeneral.org/endocrinology/article.aspx?id=1601

I trust Mass General a lot more than I trust an unsubstantiated, anonymous claim on the internet.

Seriously?! You want citations for something so well known it dates back 100s of years of conventional wisdom? You are one of those “dumb” people PP mentioned.

Citations won’t convince me. We haven’t had these drugs long enough to even have the data. Remember the miracle drug fen-phen - this is the same. It’s a miracle until it’s not and we see the long term damage. The FDA approved fen-phen and the hype was the same as it is now. Maybe you are too young to remember that.

I should mention I’m in my 50s so I’ve seen the hype before. I’m also knowingly very bias. I’m 5’3” and 130 lbs - although I wear a size 0-2 - so I’m solid muscle, like really solid.

We have a couple decades of data but you don’t want to believe it because it makes you mad.

Same with fen-phen. And as I said - I don’t care what you do to your individual body. You could take prescription Adderall or non prescription speed and get the same effect - I also don’t want those normalized in society, just as this drug shouldn’t be normalized. I also don’t believe in normalizing pot, lsd, oxy, coke, fentanyl - most of which were legal at some point in history - and there is a reason they are no longer legal.

You've made too many stupid comments to catalog in this thread (and I'm only halfway through it) but "fentanyl is illegal" is so idiotic it is worth calling out. Same for OxyContin.

Is it though? Oxy - heroin - fentanyl is a well established pattern. It’s even in Revenge of the Tipping Point, but you’d have to be able to read above 5th grade level to get that reference.

Nice diversion, or attempt, at least. Oxy and fentanyl are not illegal, though. What made you claim otherwise?

Nice diversion. I didn’t claim they were.

Sigh.

Earlier in this thread, someone wrote:

I also don’t believe in normalizing pot, lsd, oxy, coke, fentanyl - most of which were legal at some point in history - and there is a reason they are no longer legal.

If that was you, you are an idiot.

If that wasn't you, you responded to my comment as if you were the author. But regardless, when I wrote that it was idiotic to claim that fentanyl and Oxy are illegal, you responded, "Is it though?"

To answer your question directly, yes, it is. Because they are not illegal. So we have established that the initial PP is an idiot, and you, in defending him or her, also is an idiot.

I am happy to have cleared that up for you.

Sigh. . . And you’re a childish name caller who can’t deal when people disagree with you.

[Anonymous]

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

Yes. Which is why people should get on and stay on the meds.

[Anonymous]

Anonymous wrote:

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Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

There is no proven way to lose weight without a very high likelihood of yoyo weight.

[Anonymous]

So it is this awful cycle of you gain weight, you move less, you then spend more time eating to comfort yourself, by gaining weight you have more aches and pains like knee pain so you end up moving even less. You think about food all day and what you will have for your next meal. It really becomes a constant thought. Once you get used to eating more and moving less it just becomes ingrained that is your destiny.

GLP-1's break this cycle. It quiets the "food noise" that overweight /obese people have often ALL day. You eat and suddenly you feel full much sooner, you don't feel the need as often as before so instead of eating breakfast at 8, a snack at 10, lunch at 12 and a snack at 2, you eat skip breakfast/ eat tiny bit for breakfast and eat lunch at 12 and are fine until dinner. Once you start loosing weight you can try to exercise and it becomes easier as you loose weight.

Long-term the more practice you have with eating less and exercising more is only going to help a person.

It is hilarious "a practicing obesity medicine specialist" is against GLP-1's, cynically I think this is because he probably realizes that because so many people are successful on GLP-1's he is getting pushed out of his speciality.