"I No Longer Think GLP-1s Are the Answer — The drugs "work" but may be working against us long-term"

[Anonymous]

I am happy for people who are losing weight on meds.

However, although they are now thin, IMO they don’t look good. Their skin is gaunt and they look sickly. I understand it’s better than being overweight.

I also think there will be some bad side effects that are yet to be discovered.

[Anonymous]

Anonymous wrote:I am happy for people who are losing weight on meds.

However, although they are now thin, IMO they don’t look good. Their skin is gaunt and they look sickly. I understand it’s better than being overweight.

I also think there will be some bad side effects that are yet to be discovered.

Lmao no one cares how you think they look. Also, I’ve been maintaining at 24.9
BMI for 1.5 years on Wegovy. You’d never know from looking that I was taking a GLP-1.

[Anonymous]

Anonymous wrote:

Anonymous wrote:After being a size 4 from teens into my late 40s,I was on a strict whole 30 and weight watchers diet simultaneously and was still gaining 20-30 lbs a year after i went through menopause and had some other metabolic issues almost reaching 200 lbs - glp-1s have been great for me and I am very open about being on them to try to counter the judgement on this thread. If diet and exercise alone work for you great - but mind your own business re: others

I have no judgement for anyone that uses a GLP-1 but I do not want to spend tax dollars or pay increased premiums to enrich big pharma when it doesn't improve health for three quarters of people that use the drugs.

And I don’t want tax dollars to be spent on quadruple bypass surgery for obese people, or chemo for smokers with lung cancer. It’s. Slippery slope

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:After being a size 4 from teens into my late 40s,I was on a strict whole 30 and weight watchers diet simultaneously and was still gaining 20-30 lbs a year after i went through menopause and had some other metabolic issues almost reaching 200 lbs - glp-1s have been great for me and I am very open about being on them to try to counter the judgement on this thread. If diet and exercise alone work for you great - but mind your own business re: others

I have no judgement for anyone that uses a GLP-1 but I do not want to spend tax dollars or pay increased premiums to enrich big pharma when it doesn't improve health for three quarters of people that use the drugs.

And I don’t want tax dollars to be spent on quadruple bypass surgery for obese people, or chemo for smokers with lung cancer. It’s. Slippery slope

The majority of people do not stay on GLP-1 drugs, so the majority of the time these drugs confer no health benefit.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

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Anonymous wrote:

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Anonymous wrote:

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Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

There is no proven way to lose weight without a very high likelihood of yoyo weight.

So let's choose the option that's free and has the same result.

Go for it! I’m choosing the option that cost me 25 dollars a month and actually works , whereas the last 20 years of dirt and exercise and thinking of food constantly has not. For me. We both win!

I'm glad it works for you. But a drug that the majority of people do not use as intended is not a particularly effective drug.

Well then I have some bad news about birth control for you…

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:After being a size 4 from teens into my late 40s,I was on a strict whole 30 and weight watchers diet simultaneously and was still gaining 20-30 lbs a year after i went through menopause and had some other metabolic issues almost reaching 200 lbs - glp-1s have been great for me and I am very open about being on them to try to counter the judgement on this thread. If diet and exercise alone work for you great - but mind your own business re: others

I have no judgement for anyone that uses a GLP-1 but I do not want to spend tax dollars or pay increased premiums to enrich big pharma when it doesn't improve health for three quarters of people that use the drugs.

And I don’t want tax dollars to be spent on quadruple bypass surgery for obese people, or chemo for smokers with lung cancer. It’s. Slippery slope

The majority of people do not stay on GLP-1 drugs, so the majority of the time these drugs confer no health benefit.

Then we should focus on keeping people on the drugs including by reducing costs. Problem solved!

[Anonymous]

Anonymous wrote:I am happy for people who are losing weight on meds.

However, although they are now thin, IMO they don’t look good. Their skin is gaunt and they look sickly. I understand it’s better than being overweight.

I also think there will be some bad side effects that are yet to be discovered.

When you lose weight “naturally” people say this same shit. It’s the weight loss that’s changing people’s faces and skin, not the hormone receptor inhibitor.

[Anonymous]

"So teachers are obese but you don't want them to get the meds needed to lose weight because it costs too much? Maybe the issue is with manufacturers and drug prices, but we all pay for very costly meds for all sorts of people including meds that are needed due to lifestyle issues."

Where is your data source that teachers have GLP-1 meds as part of their health care plans? Also, that they are part of the group not staying on the GLP-1 meds? This is crazy speculation undeservedly aimed at teachers. You must have a lot of hate in you to randomly scapegoat teachers in this discussion.

[Anonymous]

Seems like there is this undercurrent of anger and/ jealousy that “fat” people now have an easy button allowing them to dramatically improve the quality of their lives and improve their body composition with any hard work. That they were somehow lazy and sedentary before which lead them to be a massive burden on society because of how much all the weigh related heath problems cost. And that now these “fat” lazy people are getting access to a cheat code they don’t have to work for. I’m not fat but still was above where I needed to be. Even with weekly workouts and cardio life, work, kids, supporting elderly parents and just getting old meant I was on track for potential heath problems down the road. If you plan to take this until you die and commit to weigh bearing exercises any hypothetical downside risks would be more than outweighed by real risks like type 2 diabetes, fatty liver disease, high blood pressure, heart diseases plus need for cpap machines to counter sleep apnea, mobility devices etc. in the long run heath costs should drop simply
Precisely because all the fatties have access to to these drugs

[Anonymous]

Anonymous wrote:
"So teachers are obese but you don't want them to get the meds needed to lose weight because it costs too much? Maybe the issue is with manufacturers and drug prices, but we all pay for very costly meds for all sorts of people including meds that are needed due to lifestyle issues."

Where is your data source that teachers have GLP-1 meds as part of their health care plans? Also, that they are part of the group not staying on the GLP-1 meds? This is crazy speculation undeservedly aimed at teachers. You must have a lot of hate in you to randomly scapegoat teachers in this discussion.

Our school district has specifically cited GLP-1 drugs as one of the major reasons why their health insurance fund is millions of dollars in the hole. As far as whether teachers stay on the drugs, I have no reason to believe their length of time on the drugs is any different from that of the general population and am confused as to why you think that is "scapegoating"?

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:After being a size 4 from teens into my late 40s,I was on a strict whole 30 and weight watchers diet simultaneously and was still gaining 20-30 lbs a year after i went through menopause and had some other metabolic issues almost reaching 200 lbs - glp-1s have been great for me and I am very open about being on them to try to counter the judgement on this thread. If diet and exercise alone work for you great - but mind your own business re: others

I have no judgement for anyone that uses a GLP-1 but I do not want to spend tax dollars or pay increased premiums to enrich big pharma when it doesn't improve health for three quarters of people that use the drugs.

And I don’t want tax dollars to be spent on quadruple bypass surgery for obese people, or chemo for smokers with lung cancer. It’s. Slippery slope

The majority of people do not stay on GLP-1 drugs, so the majority of the time these drugs confer no health benefit.

Then we should focus on keeping people on the drugs including by reducing costs. Problem solved!

Not really since cost is not the only reason people don't stay on the drugs. I do see the cost reduction as a potential part of the solution, but it seems like the reason for stopping the drug is that people just don't want to be on it forever.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:After being a size 4 from teens into my late 40s,I was on a strict whole 30 and weight watchers diet simultaneously and was still gaining 20-30 lbs a year after i went through menopause and had some other metabolic issues almost reaching 200 lbs - glp-1s have been great for me and I am very open about being on them to try to counter the judgement on this thread. If diet and exercise alone work for you great - but mind your own business re: others

I have no judgement for anyone that uses a GLP-1 but I do not want to spend tax dollars or pay increased premiums to enrich big pharma when it doesn't improve health for three quarters of people that use the drugs.

And I don’t want tax dollars to be spent on quadruple bypass surgery for obese people, or chemo for smokers with lung cancer. It’s. Slippery slope

The majority of people do not stay on GLP-1 drugs, so the majority of the time these drugs confer no health benefit.

Then we should focus on keeping people on the drugs including by reducing costs. Problem solved!

Not really since cost is not the only reason people don't stay on the drugs. I do see the cost reduction as a potential part of the solution, but it seems like the reason for stopping the drug is that people just don't want to be on it forever.

NYTimes says the overwhelming reason for stopping is cost and insurance dropping coverage. A much smaller percentage stop due to side effects.

[Anonymous]

Any idea how much it would cost for 10 years of treatments?

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:It seems like he likes GLP-1s and his objections are not hard to overcome:

"Reasons for discontinuation include cost, side effects, and supply shortages. But one of the most common reasons is that patients simply don't want to take a weight loss medication indefinitely. Many believe they can "beat the system," use them briefly, change their lifestyle, and stop taking them without regaining weight."

So why not educate patients so they understand the importance to stick with the GLP-1s? There are many reasonable cost options out there. The support group I am in has a wide spectrum of income. With cost going down and the ease of newer pill meds, all the objections (aside from side effects, and a switch to a different specific med can help with that) for staying on meds go away.

It sounds like his experience is patients don't stay on the drugs. I assume he is warning them they need to stay on them, but people don't want to do that. And since the majority are not staying on them and instead are cycling on and off the drugs they are just spending a lot of money for no health benefits.

Most people (no matter how they lost weight) regain the weight eventually. The benefit of weight loss is still there for the patient though: the ability to move around in the world as a normal weight person, being able to hike, sit easily on an airplane, physically be more active with kids and grandkids, having fewer health issues while on the med, not feeling addicted to food...Personally I think this is absolutely priceless even if it is fleeting because it is such better quality of life. But do I think staying on the med is best? Yes. I think that should be the takeaway rather than "don't start it because you'll stop it" which is fatalistic and not solution-oriented especially when the main objection is cost.

Weight yo-yoing (weight cycling) is generally considered bad for you, linked to increased risks for heart disease, type 2 diabetes, higher body fat, slower metabolism, and poorer mental health due to repeated stress, muscle loss, and metabolic disruption, making future weight loss harder and increasing health problems.

It is bad for you. But you're not going to find many doctors advising their patients to stay fat and not try and lose weight, despite knowing that they are likely to regain the weight (again, regardless of how they did it).

GLP-1s are costing employers and taxpayers a.lot of money. That's fine if it has a health benefit. But if there is no added health benefit then it is a net negative for health and society.

There is a cost benefit to society in having fewer obese people. Not all employer plans cover it depending on specifics, and many people go out of pocket and get compounds anyway on their own dime.

Our public school system is millions of dollars in the hole due to GLP-1s. I am all for spending money to reduce obesity sustainably but not for medication assisted yo yo dieting.

Help me see the link between failing school’s millions of dollars in debt and GLP drugs that mostly only UMC and hideously obese people use. I really can’t see it.

[Anonymous]

Anonymous wrote:I am happy for people who are losing weight on meds.

However, although they are now thin, IMO they don’t look good. Their skin is gaunt and they look sickly. I understand it’s better than being overweight.

I also think there will be some bad side effects that are yet to be discovered.

Just because you think your friends/acquaintances who have lost a lot of weight look different does NOT mean they look gaunt and sickly. That's just your opinion because they look different.

Your nastiness doesn't look good on you, sweetie.