My experience with compounded semaglutide-a cautionary tale

[Anonymous]

People have varying levels of comfort with the side effects. What OP decided was ER time other people might ride out. So it’s really hard to compare. Also it had nothing to do with compounding. The regular prescription also has common GI side effects.

[Anonymous]

Consider weight loss surgery

[Anonymous]

Yes l, the authentic medication has same side affects l. But again, with compounded could be anything.

[Anonymous]

I had a similar experience, although it was not quite as bad as yours, with Rybelsus (the pill form of semaglutide) -- the regular kind from the regular pharmacy.

[Anonymous]

Anonymous wrote:

Anonymous wrote:Compounded means the active ingredient (like semaglutide) is mixed with other fillers, but it’s not the trademarked mixture of Ozempic or Wegovy. Kind of like generic vs name brand. It is like 75% cheaper.

That is not what generic vs. name brand is. Generic is the EXACT SAME formulation.

This is a myth -- generics are not exactly the same. My doctor once refused to allow a generic version of the medication he wanted to prescribe for me because of the huge problems with the generic not being exactly the same. The brand name cost a lot more, but he said the generic version of it "kept him up at night."

[Anonymous]

i don’t think this is a compounding issue. i take ozempic (brand name) and tolerate it well. however I'm in a online group and what you experience happens occasionally to people on brand name ozempic and Wegovy. i think some people simply cannot tolerate this class of drugs. i’d say people like you are, for all practical purposes, allergic. Some people even get stomach paralysis and this is extremely dangerous!

i guarantee you the symptom you experience is on the warning label for the name brand drugs.

of course someone could have compounded your drug wrong, but your symptom is definitly a documented reaction, though severe.

[Anonymous]

I had a very similar experience. I took mounjaro & had some issues initially, but not bad. However, after 2 months I was so sick & hospitalized with rapid weight loss & had my gallbladder removed.
A year later, I tried the compounded semaglutide & it hit me at day 4! I was sick for 2 days straight (vomiting, gas, dizzy, no appetite). I'm pretty sure I had a blockage & that fully resolved itself when I started pushing myself to drink a lot of water. Anyways, I am now scared to death to take anymore! It's not worth it!!!

[Anonymous]

Anonymous wrote:I had a very similar experience. I took mounjaro & had some issues initially, but not bad. However, after 2 months I was so sick & hospitalized with rapid weight loss & had my gallbladder removed.
A year later, I tried the compounded semaglutide & it hit me at day 4! I was sick for 2 days straight (vomiting, gas, dizzy, no appetite). I'm pretty sure I had a blockage & that fully resolved itself when I started pushing myself to drink a lot of water. Anyways, I am now scared to death to take anymore! It's not worth it!!!

This is not a compounding issue. This is you continuing on a GLP-1 medication that you so responded to, you had a surgical intervention. What part of you thought that restarting a medication you responded to so significantly was a good idea?????

[Anonymous]

I had a similar reaction to Rybelsus—not compounded.

[Anonymous]

Anonymous wrote:

Anonymous wrote:Compounded means the active ingredient (like semaglutide) is mixed with other fillers, but it’s not the trademarked mixture of Ozempic or Wegovy. Kind of like generic vs name brand. It is like 75% cheaper.

That is not what generic vs. name brand is. Generic is the EXACT SAME formulation.

Generic drugs are also regulated, compounded are not.

From FDA:
“Patients and health care professionals should understand that the agency does not review compounded versions of these drugs for safety, effectiveness, or quality.”

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Compounded means the active ingredient (like semaglutide) is mixed with other fillers, but it’s not the trademarked mixture of Ozempic or Wegovy. Kind of like generic vs name brand. It is like 75% cheaper.

That is not what generic vs. name brand is. Generic is the EXACT SAME formulation.

This is a myth -- generics are not exactly the same. My doctor once refused to allow a generic version of the medication he wanted to prescribe for me because of the huge problems with the generic not being exactly the same. The brand name cost a lot more, but he said the generic version of it "kept him up at night."

Generic Injections are the same formulation as name brand.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Compounded means the active ingredient (like semaglutide) is mixed with other fillers, but it’s not the trademarked mixture of Ozempic or Wegovy. Kind of like generic vs name brand. It is like 75% cheaper.

That is not what generic vs. name brand is. Generic is the EXACT SAME formulation.

This is a myth -- generics are not exactly the same. My doctor once refused to allow a generic version of the medication he wanted to prescribe for me because of the huge problems with the generic not being exactly the same. The brand name cost a lot more, but he said the generic version of it "kept him up at night."

I was under the impression that Compounded semaglutide is a little more than just a brand/generic difference. Pharmacies are adding other stuff to the compounded injections—b12, various salts bonded to the semaglutide that may change the way it works in the body.

[Anonymous]

Anonymous wrote:Compounded means the active ingredient (like semaglutide) is mixed with other fillers, but it’s not the trademarked mixture of Ozempic or Wegovy. Kind of like generic vs name brand. It is like 75% cheaper.

It’s not kinds like generic. Generic meds are FDA approved. Compounded meds are not, and are notorious for not being what they say they are, having impurities, incorrect dosages, etc.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Compounded means the active ingredient (like semaglutide) is mixed with other fillers, but it’s not the trademarked mixture of Ozempic or Wegovy. Kind of like generic vs name brand. It is like 75% cheaper.

That is not what generic vs. name brand is. Generic is the EXACT SAME formulation.

This is a myth -- generics are not exactly the same. My doctor once refused to allow a generic version of the medication he wanted to prescribe for me because of the huge problems with the generic not being exactly the same. The brand name cost a lot more, but he said the generic version of it "kept him up at night."

I was under the impression that Compounded semaglutide is a little more than just a brand/generic difference. Pharmacies are adding other stuff to the compounded injections—b12, various salts bonded to the semaglutide that may change the way it works in the body.

Correct. The compounding pharmacists are using a recipe and can substitute, add, and alter as it suits them. Not all do, but some do. I would only use compounded Semaglutide that is independently tested after being mixed.

[Anonymous]

Anonymous wrote:The compounded meds could be anything. Norvo Nordis has strongly advised again taking them. I don't know why anyone would based on that alone.

Norvo Nordisk makes Ozempic. Obviously they want to scare people into paying a much much higher price for their drugs.