NIH Study regarding HRT and BReast cancer

[Anonymous]

Article from NIH on combined HRT for younger women states that prosteron +estradiol therapy in perimenapausal women with intact uterus adn ovaries increases the chances of breast cancer. Why do many current medical professinals say it is safe and does not cause cancer? The study i am refering to is from 2025.

“These findings underscore the need for personalized medical advice when considering hormone therapy,” said NIEHS scientist and senior author Dale Sandler, Ph.D. “Women and their health care providers should weigh the benefits of symptom relief against the potential risks associated with hormone therapy, especially EP-HT. For women with an intact uterus and ovaries, the increased risk of breast cancer with EP-HT should prompt careful deliberation.”

[Anonymous]

Scary

[Anonymous]

How about a citation?

[Anonymous]

Anonymous wrote:How about a citation?

I think OP is referring to this study:


Breast cancer risk in younger women may be influenced by hormone therapy
NIH study could help to guide clinical recommendations for hormone therapy use among women under 55 years old.

“Scientists at the National Institutes of Health (NIH) have found that two common types of hormone therapy may alter breast cancer risk in women before age 55. Researchers discovered that women treated with unopposed estrogen hormone therapy (E-HT) were less likely to develop the disease than those who did not use hormone therapy. They also found that women treated with estrogen plus progestin hormone therapy (EP-HT) were more likely to develop breast cancer than women who did not use hormone therapy. Together, these results could help to guide clinical recommendations for hormone therapy use among younger women.”

…

“According to the authors, this suggests that for EP-HT users, the cumulative risk of breast cancer before age 55 could be about 4.5%, compared with a 4.1% risk for women who never used hormone therapy and a 3.6% risk for those who used E-HT. Further, the association between EP-HT and breast cancer was particularly elevated among women who had not undergone hysterectomy or oophorectomy. That highlights the importance of considering gynecological surgery status when evaluating the risks of starting hormone therapy, the researchers noted.”

https://www.nih.gov/news-events/news-releases/breast-cancer-risk-younger-women-may-be-influenced-hormone-therapy

[Anonymous]

The current social media blitz has convinced women that the benefits of HRT are huge and risks are minimal to the point that even talking about the risks gets you labeled as a misogynist or whatever.

HRT has its place for women with severe symptoms. As someone with lifelong insomnia that impacts my mental health, I am not totally writing it off if my hot flashes get worse. But I discussed it with my long-time trusted GP and he advised that the risk of cancer wasn’t worth it and will support me in exploring other ways to address symptoms if they arise.

[Anonymous]

I second this. I recently started HRT myslef and will be stopping it. I do think that they do come with benfits but media these days is very overrared and commercialized.

[Anonymous]

I did not start HRT until after menopause. Am surprised so many start long before.

[Anonymous]

Why are you not addressing the “younger women” aspect, OP?

Also, why do you care as a man?

And why did you leave out that HRT helps with osteoporosis and other health issues?

You seem one sided.

[Anonymous]

It’s a .4% increase in risk. There are other benefits. It’s a risk analysis like anything else. Personally I’m going to try it because most women die shortly after a hip fracture.

[Anonymous]

For me personally, the risk of osteoporosis is much greater than the risk of breast cancer, so HRT is worthwhile. Everyone needs to assess their own risks and benefits.

[Anonymous]

Why is this a surprise? HRT and cancer were linked even when I was in college like 30 years ago!
Why so many people recommend HRT is beyond me!

[Anonymous]

Progestin and progesterone is not the same and the latest findings are that micronized progesterone seems much safer—but more data is needed.

[Anonymous]

All cause mortality is lower in HRT cohorts in multiple studies.

We are learning… slowly… I think many studies will be coming out in the next 3-5 years.

[Anonymous]

[quote=Anonymous]Progestin and progesterone is not the same and the latest findings are that micronized progesterone seems much safer—but more data is needed.[/quote]

Here’s the citation:
Conclusion: Although menopausal HT use appears to be associated with an overall increased risk of breast cancer, this risk appears predominantly mediated through formulations containing synthetic progestins. When prescribing menopausal HT, micronized progesterone may be the safer progestogen to be used.

https://pubmed.ncbi.nlm.nih.gov/35675607/

[Anonymous]

This doesn’t seem straightforward. I’m not smart enough to understand it all but it sounds like it really depends on what type of HrT? I’m glad they are studying it.

There also are clear benefits for heart health, which is a bigger risk for most women. I think everyone needs to consider their personal risks. My friend who is a breast cancer survivor was told no way for HRT, so I think doctors do understand the risks.