If 1st cousins keep mating generation after generation ...

Anonymous
Anonymous wrote:
Anonymous wrote:
Anonymous wrote:Saudi Arabia, high incidence of inherited conditions.


Yep. Saudi has very high Down Syndrome rates. And around two-thirds of marriages are blood relatives.


PP from the hemophilia correction here. More basic genetics knowledge is really needed on this thread!

Down syndrome is not heritable in almost all cases- it is a trisomy (ie triplicate) of one of the chromosomes. A trisomy occurs spontaneously at a very low rate after cell division. There are a few rare genes that can increase your risk of having a child with Down syndrome (because you tend to produce such trisomies more often) but those are believed to be implicated in only a tiny percentage (<5%) of Down syndrome cases.


Also, from another thread a recessive gene cannot become dominant. It is that you get two copies of the recessive gene, one from each parent, and then you start to express the recessive trait. Inbreeding increases the chance that you will get two copes of a mutant or unusual gene because both your parents originally got it from the same place.

This thread is a walking ad for why smart people should also study STEM fields. Educate your children first.
(A STEM PhD who is not even a biologist but has learned how to think about science)


Ha ha! PP here. I DO have a STEM degree AND I have worked in Saudi Arabia. The point is that the situation is different in Saudi and probably because what you said above (bold) is not so rare in that country (due to the high levels of inbreeding). Look it up before you make judge-y comments!
TwistdMike
Member Offline
Problem is... Even after the divorce, you're still related...

"Yes Bubba, she is still your sister"

Anonymous
Anonymous wrote:Infertility is another side effect. It is epidemic in the middle east, with as many as 25% of all couples unable to reproduce because of consanguinity. Iran pays for in vitro, surrogacy, donor eggs etc at state-run facilities because it has no choice if the population is to survive.


Unclear Iranian infertility is from intermarriage. Iran has the highest rate of chlamydia in the world.
Anonymous
Something I have wondered about. If two totally unrelated people marry, but one spouse comes from a long line of double first cousin and first cousin marriages, are the children more susceptible to inherited conditions than you would otherwise find?

It may be just coincidence, but DH is the product of a double first cousin marriage, as were both his parents. Before that there were first cousin marriages, but don't know if they were double or not. Half the children in his family have a rare inherited disorder. Among our own children we have epilepsy--otherwise not in either family, as well as two autoimmune disorders known to be inherited. For one we don't know of any precedent, but the other also occurred in one of his double first cousins.
Anonymous
Anonymous wrote:
Anonymous wrote:Most genetic defects are mutations. They have nothing to do with parents, parents' marriages, and inbreeding.


Genetic defects are mutations that can be passed on to the offspring. If you have two parents that have the same recessive mutation then they have a 1/4 chance of both passing on that gene to their child and cause the manifestation of the disease in that child.


True, but I was pointing out that whether the first person that has the de novo mutation is part of a long line of cousins is irrelevant.
Anonymous
Birth defects and huge rates of learning disabilitys; not to mention it is the poorest place in the US with fewer English speakers than a Mexican border town, just about 40 minutes from Manhattan lies a thundering horde of cousin fuckers....
https://en.m.wikipedia.org/wiki/Kiryas_Joel,_New_York
Anonymous
Anonymous wrote:Birth defects and huge rates of learning disabilitys; not to mention it is the poorest place in the US with fewer English speakers than a Mexican border town, just about 40 minutes from Manhattan lies a thundering horde of cousin fuckers....
https://en.m.wikipedia.org/wiki/Kiryas_Joel,_New_York


Hilarious!!
Anonymous
Anonymous wrote:Infertility is another side effect. It is epidemic in the middle east, with as many as 25% of all couples unable to reproduce because of consanguinity. Iran pays for in vitro, surrogacy, donor eggs etc at state-run facilities because it has no choice if the population is to survive.

Persians don't actually marry cousins very often, and they have fewer children, making cousin marriage even less possible.

Unlike Saudi, where first cousins can easily number 50+, and the choices are much greater.
Anonymous
Anonymous wrote:Fragile X is a recessive trait that can cause intellectual disabilities.

OP: If you are worried about this, your intended and you can have genetic testing for these things. National Children's did mine.

I didn't marry my cousin but did come from a family with known fragile X and I wanted to make sure I was not a carrier.

Genetic testing is kind of fun.


Fragile X is x-linked, not recessive. It also gets worse as the mutation is passed from generation to generation (the term for this is anticipation). Females are generally unaffected because they have two copies of the X chromosome. But it is not a classic recessive disease, which requires inheritance of two mutated copies of the gene to cause disease. Affected males have one X chromosome that carries the mutation.
Anonymous
Anonymous wrote:
Anonymous wrote:
Anonymous wrote:Most genetic defects are mutations. They have nothing to do with parents, parents' marriages, and inbreeding.


Genetic defects are mutations that can be passed on to the offspring. If you have two parents that have the same recessive mutation then they have a 1/4 chance of both passing on that gene to their child and cause the manifestation of the disease in that child.


True, but I was pointing out that whether the first person that has the de novo mutation is part of a long line of cousins is irrelevant.


Most de novo mutations end in miscarriage. The majority of genetic defects are inherited. One round of cousins reproducing won't increase the odds of disease but several generations of cousin marriages will cause problems in the offspring.
Anonymous
Anonymous wrote:
Anonymous wrote:Any recessive genetic disorders in that family start cropping up.


This.

Which is why marrying a first cousin is illegal in many countries.



It's not illegal enough. Religion allows it.
Anonymous
Anonymous wrote:
Anonymous wrote:Any medical professionals out there? What is the effect on offspring, if first cousins keep producing children, generation after generation. Does this do something to their brain?


Inbreeding doubles the risk of birth defects and can trigger latent, recessive genes with regards to rare medical conditions.





Other than latent recessive gene issues, what does inbreeding repeatedly do to the brains of the offspring and consequently population?

I grew up thinking that inbreeding made people stupid and that was before I learned that cultures still do that in the world, especially Amish & Muslims.
Anonymous
Anonymous wrote:Look up the Pakistani population in the UK.


Yes, there was a story on NPR a couple days ago and one of the women was a British Pakistani who was bethrothed to her 1st cousin when she was born. Their mothers promised their babies to the other mother's child for marriage. She "escaped" her fate when her mother died and came to America to study. She is one of the creator's (with an Indian woman) of a tv show here in America.
Anonymous
Anonymous wrote:
Anonymous wrote:
Anonymous wrote:
Anonymous wrote:Any medical professionals out there? What is the effect on offspring, if first cousins keep producing children, generation after generation. Does this do something to their brain?


Inbreeding doubles the risk of birth defects and can trigger latent, recessive genes with regards to rare medical conditions.



For example, the fundamentalist Mormons have terribly high rates of a specific mental retardation that is very, very rare among the general population.


The polygamists? I saw a show about this. And they have as many kids as they can and the children are just completely incapacitated for their whole lives.


Why are the kids incapacitated their whole lives? Because they don't get any attention from their parents?
Anonymous
Anonymous wrote:Fragile X is a recessive trait that can cause intellectual disabilities.

OP: If you are worried about this, your intended and you can have genetic testing for these things. National Children's did mine.

I didn't marry my cousin but did come from a family with known fragile X and I wanted to make sure I was not a carrier.

Genetic testing is kind of fun.


OP here. No, I am not mating with my 1st cousin and disgusted by the thought that it still occurs in the 21st century. I'm concerned with regions of the world where this does occur as a matter of life and culture and often those regions are warring.

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