If 1st cousins keep mating generation after generation ...

[Anonymous]

Any medical professionals out there? What is the effect on offspring, if first cousins keep producing children, generation after generation. Does this do something to their brain?

[Anonymous]

Oh my.

[Anonymous]

Any recessive genetic disorders in that family start cropping up.

[Anonymous]

I'm a bit afraid to ask, but why do you want to know?

[Anonymous]

Habsburg jaw. Ugh.

[Anonymous]

Hemophilia, in one famous case.

[Anonymous]

Anonymous wrote:Hemophilia, in one famous case.

Umm, no. You only need 1 copy of the bad gene to have the problem if you are male. In inbreeding, a single mutation is then passed to one chromosome of multiple relatives and eventually some of their descendents end up with two copies of the same recessive gene which causes the problem.

Hemophilia came from Queen Victoria and the big problem was that she had 12 children and they married royalty throughout Europe, spreading this gene.

[Anonymous]

Anonymous wrote:Any recessive genetic disorders in that family start cropping up.

This.

Which is why marrying a first cousin is illegal in many countries.

[Anonymous]

Their skin can turn blue.

[Anonymous]

https://kentuckybluepeople.wordpress.com/inbreeding-in-eastern-kentucky-christine-voll/

[Anonymous]

Not OP- This happened twice in a great uncle's line of the family. Those descendants are all very nice but are definitely "slow"

[Anonymous]

Anonymous wrote:

Anonymous wrote:Any recessive genetic disorders in that family start cropping up.

This.

Which is why marrying a first cousin is illegal in many countries.

It is illegal in some countries. Whereas in other countries, it's a common custom.

[Anonymous]

Look up the pharaohs of Egypt. Lots of inbreeding there.

[Anonymous]

Anonymous wrote:

Anonymous wrote:Hemophilia, in one famous case.

Umm, no. You only need 1 copy of the bad gene to have the problem if you are male. In inbreeding, a single mutation is then passed to one chromosome of multiple relatives and eventually some of their descendents end up with two copies of the same recessive gene which causes the problem.

Hemophilia came from Queen Victoria and the big problem was that she had 12 children and they married royalty throughout Europe, spreading this gene.

And who kept marrying each other, thereby increasing the occurrences.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Hemophilia, in one famous case.

Umm, no. You only need 1 copy of the bad gene to have the problem if you are male. In inbreeding, a single mutation is then passed to one chromosome of multiple relatives and eventually some of their descendents end up with two copies of the same recessive gene which causes the problem.

Hemophilia came from Queen Victoria and the big problem was that she had 12 children and they married royalty throughout Europe, spreading this gene.

And who kept marrying each other, thereby increasing the occurrences.

Actually, no. The PP is right. The problem was that she had 12 children and they married royalty throughout Europe, spreading this gene. This is not a cousin-marriage issue.

https://en.wikipedia.org/wiki/Haemophilia_in_European_royalty