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Reply to "If 1st cousins keep mating generation after generation ..."
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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]Most genetic defects are mutations. They have nothing to do with parents, parents' marriages, and inbreeding.[/quote] Genetic defects are mutations that can be passed on to the offspring. If you have two parents that have the same recessive mutation then they have a 1/4 chance of both passing on that gene to their child and cause the manifestation of the disease in that child.[/quote] True, but I was pointing out that whether the first person that has the de novo mutation is part of a long line of cousins is irrelevant.[/quote] Most de novo mutations end in miscarriage. The majority of genetic defects are inherited. One round of cousins reproducing won't increase the odds of disease but several generations of cousin marriages will cause problems in the offspring.[/quote]
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