How many donor egg transfers until you had success or called it quits?
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Anonymous
| I just found out that my 3rd donor egg FET didn't take. Just wondering what other people's experience has been with donor egg transfers and how many it took to get a BFP or to call it quits. Just some background - after having my DD naturally at age 37, I started IVF at 38. I had 5 failed OE cycles with no genetically normal embryos. I'm now 41 and have done 3 donor egg embryo transfers - 2 didn't take at all and 1 resulted in blighted ovum. I have one lower-graded embryo left from the same donor egg batch. I've done an ERA and neither me or my husband have any known issues. Is there any other testing I should consider? I'm so discouraged that I'm not sure I want to even try the last embryo -- I'm in shared risk so I could walk away and get my money back. Just seems like if having 3 failed donor egg embryo transfers doesn't bode well for success with the 4th. |
Anonymous
| We did 7 and have moved to DE. I'm sorry it hasn't worked yet. There's so much promise and hope with starting a new cycle and it's hard to know when exactly to stop. Our doctors suggested we stop, so that helped. I also decided this is enough for me and I don't want to put my body through more. I sort of wish I stopped sooner. |
Anonymous
| OP here to PP - did you do 7 donor egg transfers or 7 OE cycles and have moved on to DE? Thanks! |
Anonymous
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1 transfer (frozen DE) which took. 29 weeks pregnant and counting...
Have you looked into immunological issues? Did you PGS test your donor egg embryos. Since I fertilized donor eggs with my own eggs during an IVF cycle mine were tested along with my own egg embryos - of 5 22y.o DE blastocysts 3 were aneuploid (2 with survivable aneuploidies), 1 was indeterminate and only one was euploid. If I had transferred based on Grade alone would likely have transferred 2 of the aneuploid embryos first and then the indeterminate one before doing the euploid one.... I know PGS testing of DE embryos is controversial but it really paid off for me. I also did a lot of mind - body work regarding fertility and embryo implantation... |
Anonymous
| OP to PP - that’s interesting that based on the appearance of the embryos alone you would have chosen poorly - guess that means my lower graded blast may have just a good a chance as the AA ones that failed. We did not get our donor embryos PGS tested but in hindsight I wish we would have since my doctor said the blighted ovum was almost certainly aneuploid and I could maybe have avoided a miscarriage and D&C. Congrats on your pregnancy! |
Anonymous
| We tried with donor eggs 3x, but they were lots from several different donors because we would only get one egg to blast out of 6-7 eggs. On the middle try I did get pregnant with the one egg, but it was a miscarriage. We stopped because we had to start the whole donor process over each time and my hormones were off the chart. It just felt like it was time to stop. I think you’ll know in your gut when it’s time. If all your tries have been with one do though I would suggest trying a different donor as maybe it could be that donors eggs. |
Anonymous
| i PGT tested our donor eggs-- from 11 fertilized we only got 3 to freeze, and one of those was not euploid. MMC with the first, still going (19w) with the last. I thought you needed to use all of the embryos to get your full refund though? |
Anonymous
We did 7 OE transfers, and we are now moving to DE. If money isn't an issue, many people seem to just know when it's time to call it quits and try a different approach. Not sure how many DE rounds we'll try. We'll see how it goes. |
Anonymous
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Good luck to you all. We did 3 IUIs and 9 IVF cycles before transitioning to DE. I assumed DE would not work, so pursued shared risk. Our first transfer worked and we have a healthy 16 month-old.
Sending so much love and positive fertile vibes to you. |
Anonymous
| Two retrievals, three transfers |
Anonymous
| Has your partner had a DNA fragmentation test done? |
Anonymous
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OP here - thanks everyone for your comments & congrats to those of you who have had success! To answer a few questions that have been posed - SGF lets you leave the shared risk program at any time but if there are frozen embryos you have to destroy those before you can get your money back. I hate the thought of destroying the last embryo so I'll probably try again. I just feel like I might lose it if I have to get another shot of PIO in my a**. I'm so tired of all the meds and side effects.
My husband went to a doctor to check for a veriocele (sp?) vein and they were supposed to do a DNA fragmentation test but forgot to get the sample! I just dropped it at the time since my husband is so touchy about it possibly being his sperm that's the issue & my doc at SGF has repeatedly told us it's an egg issue, not a sperm issue. But now I've taken my eggs out of the equation and it's still not working so I'll broach it again. Would love to hear from anyone who was told it was an egg issue and it turned out to be a sperm issue! We did get much better fertilization and blast rates with the donor eggs, which led to me believe it was indeed an egg issue. I wish I would have gotten the embryos PGS tested... |
Anonymous
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Good luck OP! I would try again with the last embryo. If you do a natural FET cycle PIO is not required. (The suppositories are annoying but not painful.)
May be something to consider. |
Anonymous
I'm shocked at this. They absolutely need to do a fragmentation test. And I would yell at both your doc and husband. Unless you know for certain there's no issue with the sperm it can absolutely be a sperm issue and not an egg issue. Your body has been through so much! Your husband needs to get over it. |
Anonymous
| We purchased a frozen lot (8 eggs) with a guarantee of two high quality blast. We got exactly two. First transfer ended in an early MC and I'm 28 weeks with the second. I encourage you to transfer the lower quality after you do dna testing and an immune profile, if you haven't already. Most good doctors and geneticists will readily tell you that grading is a tool that's helpful, but often not accurate. It's not uncommon for the lower grades to end in healthy babies. Good luck! I'm sorry it's been such a long road for you, it's rough. |