DOR, almost 41.
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Anonymous
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Hi all. Was dx with low amh/dor years ago at 34. Took 3 years and 4 cycles to get my DD (now 3 and a half). She was a fresh three day transfer (i’ve never gotten anything to blast). Since she was born we did two banking cycles and froze 8 day three embryos all top graded (i was 37 and 38 at that time). Well i’ve just transferred the last of the 8 and another CP last week.
What should I do? I know at almost 41 (AMH is .1) my eggs are most likely all shot but the plan was always to go right back and cycle if this last transfer didnt work but now with COVID I know i’m going to lose 3-6 months. I have gotten pregnant naturally 3 times in 5 years but those have all ended in early miscarriages. Supplements? Hypnosis? Throw in the towel? CCRM? I ovulate like clockwork and have regular cycles. Husband has no issues. |
Anonymous
| What clinic are you at? Have you consulted with other clinics? We’ve also had trouble getting blasts (not DOR though) And had a day 3 transfer that ended in miscarriage and have another frozen day 3 embryo. We’ve consulted with a bunch of other clinics and they’ve all told us that, in their labs at least, if the embryo doesn’t make it to blast, it has an infinitesimally small/ no chance of resulting in a live baby. So they all said growing to blasts would just be like ripping of the bandaid. We are focusing on lab quality while making our choice going forward, but of course that’s the one factor that is basically impossible to measure. |
Anonymous
| I would call dr DiMattina at Dominion. Try natural cycle with assisted hatching and icsi. |
Anonymous
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Honestly? I would use the next few months to start exploring donor egg and having that conversation with spouse.
You can also do Skype or phone consults with top fertility clinics right now while you wait - maybe CCRM CO and Cornell - just to feel like you are making as informed of a decision as possible. |
Anonymous
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If you want to try CCRM, I strongly recommend you go to CCRM in Colorado. I have a very similar profile and my attempt with CCRM NOVA was a huge waste of time money and effort.
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Anonymous
| I’m 35 and my eggs are shot, a few CP/early MC, many rounds of IVF with nothing making it to blast and failed day 3 transfers. That sounds like you, but add 5 years? Honestly, if I were you (and I sort of am), I’d save your money and the heartbreak and do donor egg or embryo if you REALLY want a second child. It is what it is and it’s unfair, I’m really sorry. |
Anonymous
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I am 41 year old, and I just gave birth to my second child last month. My first child was conceived naturally at 37.
DOR AMH was ~ 0.2 when I started around 40 yrs old, otherwise healthy and fit. Had three cycles of natural IVF with Dominion. First cycle (in the month when I turned 40) didn't take, second cycle (five months later) the didn't made to day 5, the third one (the very next month) is sleeping in baby carrier right now. I was incredibly lucky, hope the same with you! |
Anonymous
| Not the OP, but similar stats. 41, DOR, recent AMH .251 and AFC was 8. Just got news today that the IUI failed (first effort at all), which I expected but still... deflated. Am I wasting my time? |
Anonymous
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Donor egg or adoption are the only good ways to ensure you have a second. % if good eggs is typically low at 41, and with DORcu get fewer, so odds of getting one to work are lower.
You could get lucky, but it’s far more likely you won’t (which I’m sure u know). Supplements take 3 months to have any effect. I feel like they delay the decline that happens in ur 40s, not really improve things (no data just a thought). If donor egg is an option for u, I recommend it. I got pregnant with my first almost immediately at 39. Tried for #2 for a short time and went to an RE to find out DH has severe MF. Unless sperm count is zero, MF is WAY easier to deal with than DOR or egg quality issues. Started IVF just after turning 42. Got lots of eggs, but no blasts until I tried a mini IVF (where u don’t get as many). By then I was getting close to 44 and for sure quality was low. Went to DE and it was successful on the first round. Obv DE isn’t for everyone, just sharing my experience. If u do try again, I’d recommend Cornell, but with Covid, not sure it’s feasible. |
Anonymous
I'm sorry about your IUI, PP. The general rule of thumb is that DOR means fewer eggs, but not lower quality. But for me and others I know, quality was totally shot as well. DOR is really devastating when it's combined with egg quality issues. Unfortunately, you can't tell if you have quality issues unless you do an IVF cycle and try to grow them out in the lab. If I were you, I'd skip the IUIs (you may get insurance approval for this if you have MFI or other specific issues) and do an IVF cycle or two ASAP. If you can grow blasts, that's great. If you can test and get a normal or two, that's awesome. If you can't make blasts, then yeah, you may want to look into donor options or adoption sooner rather than later. I spent a LOT of time and mental energy on IVF cycles that had low odds of success. I definitely feel like I gave it my best effort, but I don't ultimately know whether it was worth the stress and heartache. |
Anonymous
| Thank you; I really appreciate it. Question since I haven’t gotten to IVF yet; do you all typically do the genetic testing? Trying to figure out how much I need to save/finance. |
Anonymous
Personally, I even did PGT on my *donor egg* embryos—I don't have time to waste on testing them out in my uterus. 1/3 were abnormal. It was a $5000 rider for SGF donor shared risk. |
Anonymous
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OP here.
I’m going to give it one last shot (now officially 41) and do one more cycle. I’m currently estrogen priming. If I can actually get a blast I’m going to test, I can’t deal with another MC. I’m done with transferring day 3 embryos and truly consider my daughter (now almost 4) a miracle. I’ve never made a blast in the lab but have had chemicals on my own. We also did DNA frag test on DH and he came back totally normal as usual. So it’s my crappy eggs. |
Anonymous
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If you can make blasts, then definitely worth testing. I have two friends that had healthy babies with mosaic embryos, so I'd be sure the lab would save those.
PP, also can't make blasts, also have had chemicals on my own. Also have an older child that I now consider a miracle! |
Anonymous
| Morning everyone — when you say you have bad eggs, is that from the grading thing you get as a result of IVF? Thank you; I appreciate you all. |