Implantation failure_Secondary unexplained infertility

[Anonymous]

All our tests are not only normal but also on the above average side
No endometriosis
No DOR
No PCOS
No hormone disorder
No blocked tube
No major immunology problem
Very mild blood clot disorder but also not major
Responded well to stimulation
High fertilization rate
All embryos made to blast are PGD/PGS normal
No history of chemical or miscarriage
First child conceived naturally immediately years ago, and carried to full term. Uneventful pregnancy
Yet frozen transfer of a high graded tested embryo (with PIO, progesterone, estrogen, blood thinner, immunology drugs) failed, not even a chemical. What is wrong with me.
Anybody else is/was in similar situation to tell me your experiences?

[Anonymous]

One transfer so far?

[Anonymous]

If you’ve only done one transfer, it’s not a sign that anything more is wrong with you then you already know. Even women doing IVF in their 20s for reasons unrelated to egg quality have a less than 50% chance each time. If you have egg quality problems (and it sounds like you do) the stats are lower. Can you talk with your doctor about what your actual statistical chances are so you feel prepared next time?

[Anonymous]

How many tested embryos do you have?

[Anonymous]

There’s a reason it’s called “unexplained.” Despite ALL the information you have and the sophisticated measures you’ve taken, it all comes down to the right egg meeting the right sperm and landing in the right spot. The best fertility doc cannot control that. You presume there should be an explanation about why it did/didn’t work when, in fact, there isn’t one. You did everything you could and then rolled the dice. It truly is a miracle that any of this results in a live baby.

I’m sorry this is happening and that there aren’t any conclusive answers. I was in your boat—got pregnant on the first try unassisted. And then nothing for try after try. Ironically the time it worked was the time it shouldn’t have worked—no drugs, poor quality sperm, IUI. And yet it did, and there’s no explanation.

[Anonymous]

Anonymous wrote:There’s a reason it’s called “unexplained.” Despite ALL the information you have and the sophisticated measures you’ve taken, it all comes down to the right egg meeting the right sperm and landing in the right spot. The best fertility doc cannot control that. You presume there should be an explanation about why it did/didn’t work when, in fact, there isn’t one. You did everything you could and then rolled the dice. It truly is a miracle that any of this results in a live baby.

I’m sorry this is happening and that there aren’t any conclusive answers. I was in your boat—got pregnant on the first try unassisted. And then nothing for try after try. Ironically the time it worked was the time it shouldn’t have worked—no drugs, poor quality sperm, IUI. And yet it did, and there’s no explanation.

OP here. Can you tell me your story? Did you have failed IVF (how many) then got succeded with non-stimulated IUI?

[Anonymous]

This is the crap part of UI. Everything can look perfect on paper and it just doesn’t work in actuality. Agree with others if you’ve only had one transfer to keep your chin up and try another (and maybe another). It sounds like you have good quality eyebrows and are pretty healthy. (Presuming you’ve talk to your doctor about taking baby aspirin/enoxoparin due to your clotting disorder). The way I looked at it when I was in your shoes with unexplained, is that it’s just a numbers game. You may not be on the right side of the success curve yet. Wishing you luck in your next transfer. Please don’t lose hope!

[Anonymous]

OP, with unexplained infertility, even under the best circumstances, an FET can fail. If you are lucky to have other frozen embryos, stay positive and try again. My daughter was born when I was nearly 42, after 6 x IUI and one failed transfer (out of only two PGS normal embryos). It’s unfortunately a lottery. Good luck!

[Anonymous]

Have you tested for thyroid antibodies?
Anecdotally, women who have a boy as their first child are more prone to develop immune issues.

[Anonymous]

Likely nothing is wrong with you. A lot of this is just luck of the draw.

[Anonymous]

If you haven't had it already, ask for a beta-3 integrin biopsy. Beta-3 integrin is a protein that's supposed to be in your uterus at the time of implantation. If it isn't there, even perfect embryos won't be able to implant. The treatment is 2-3 months of Lupron Depot, which generally will restore the beta-3 for a cycle or two but since the cure is only temporary, it pretty much has to be done in conjunction with IVF.

[Anonymous]

I had an ERA (needed additional day) and was also given letrozole. Also had polyp removed month before transfer. The embryo had hatched once thawed. Not sure if those things mattered, but I did get pregnant 1st time around and my chances were in the 10-15% range.

[Anonymous]

Ok so I need the ERA and endometrial biopsy for beta 3 integrin.

They didn't find any polyps in my uterus. My lining thickness is always good naturally without drugs. They did full immunology test panel so I assume all antibodies problems have been covered. I just don't want to blindly waste all my frozen embryos away if there is indeed something I can do differently.

[Anonymous]

Just had my beta today for my donor egg embryo transfer and it was negative. I’m sorry we are both in this crappy boat, OP. But I have to agree with previous posters. Sometimes they just don’t implant and nobody knows why. I have 2 more embryos and have to just pray that one sticks.

[Anonymous]

I'm so sorry, PP.