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"I No Longer Think GLP-1s Are the Answer — The drugs "work" but may be working against us long-term"
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Anonymous
Sure it existed, but not at 40% of the population. Most people were turned away from military service, even during WWII for being too slim. It’s an inconvenient truth for you. And you don’t need to be so triggered googlable facts - it doesn’t help your case. |
Anonymous
DP: Also fen-phen essentially IS speed -- they are serotonin and norepinephrine releasing agents, which is preceicely why they were addictive and dangergous and caused heart failure. They are stimulants, just as adderall is a stimulant, but they are different chemicals and were/are prescribed differently. GLP-1 are not stimulants, they are hormones, and if you want to compare them to other medications, you should compare them to that class of drug, like birth control, HRC, thyroid medications, testosterone, insulin, prednisone and other steroidal medications, like those used to treat accute repiratory distress. |
Anonymous
Yep ^^, just an idiot with no life and nothing better to do aside from trying to enrage people on the internet by saying ridiculous things. This is just one poster posting all over this thread trying to enrage reasonable people. Don't take the bait. |
Anonymous
I am one of those scientists (PhD) - I guarantee you there is a lot that goes into those tests that don’t make it to the public. These drugs are good for people who have medical problems from obesity. I do agree with all the PPs that say if you don’t fall into the category of medical problems due to obesity, you shouldn’t be on them - it’s abuse of its intended purpose and the consequences will be known later. Many drugs stay in the testing phase for decades- it doesn’t mean they are safe. The drug industry pushes certain drugs to be commercialized for profit, so there is lots of pressure to make it widely available. People get rich on selling this to you and those people don’t have to live in your body long term. |
Anonymous
Your ignorance is stunning. There are many people who become overweight without eating a lot of "junk". Having an illness or injury or being on a medication that causes weight gain is very common. Yes, some people get fat from eating a lot of junk, but not everyone. Also, some people do not have an income that allows them to avoid "junk" or live in food deserts that make it hard to eat healthy. Also, the numerous studies on GLP medications show that the control groups on the same food or exercise regimes did not in fact lose weight to the same degree as the GLP groups - proving exactly contrary to your assertion that, "if they went on the diet without the drug, they'd have the same results." That is why these medications are considered so revolutionary. They accomplish something that cannot be accomplished by diet and exercise alone, especially when considered across a group. For example, maybe the mean weight loss in a control group was 5% bodyweight loss, but the GLP mean bodyweight loss was around 20%. |
Anonymous
You are so right. I made the mistake of reading into the PP something coherent, and there isn't anything coherent there. |
Anonymous
I meant the moronic ozempic hater that person was quoting. |
Anonymous
Be brave and blow the whistle then. |
Anonymous
Me again - I should have mentioned the risk. There is uncertainty about the impact of GLP drugs on C-cell changes, which means long term they may cause cancer - gastrointestinal a colorectal a not all cancers are the same. We don’t have all the data on this yet, so it’s inconclusive. They lower the risk of cancers in very obese people, because their risk was much higher due to the obesity. They may increase cancer risk in healthy moderately overweight people. |
Anonymous
Bless your heart in thinking all this! |
Anonymous
DP but as a lifetime yo-yo sufferer before GLP1s I really have no idea what you think you’re objecting to. If your appetite is naturally too big (mine is) the problem is portion. I have eaten very clean since my first major weight loss at age 17 (lost 90 lbs). I didn’t eat a single Dorito, cookie, brownie, fry, NOTHING for decades. But my weight would still go up when I would drop the calorie counting and just eat healthy food but according to my “natural” appetite level. Never back up to my high of 230, but 50-60 lbs above my low. Part of that is because losing weight due to calorie restriction changes your metabolism, but also, my problem was my appetite. GLPs fixed that. |
Anonymous
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Do whatever you want.
I lost a lot of weight 46 years ago. I have kept 85% of it off. Gain from age, menopause, bad habits. Stable for about a decade. I was over 300 pounds, so that's 30 pounds over my lowest weight, 20 over goal. I thought about the new drugs but decided no. I realize my loss was atypical but that's my experience. |
Anonymous
Yes, lifetime maintenance like you have managed is rare, and there is a truly crushing amount of data about re-gain to support that. |
Anonymous
It’s not about blowing a whistle. All medications go through this process and many of them get pulled when the negatives outweigh the positives. All I’m saying is there is not enough long term data and much of what we have is inconclusive. Some drugs pulled in the past that were initially approved are: Fen-phen (as mentioned above) Sibutramine Rimonabant Aminorex DNP TRIAC Amongst others They are pulled due to organ toxicity, cardiac/psychological/metabolic problems. This one, GLPs, might also have increased risk of psychiatric problems, but similar to cancer risk there is no conclusive evidence yet. Especially since obesity could be a symptom of mental health issues; it’s difficult to separate these. |
Anonymous
This goes both ways. GLPs have been associated with so many positive health outcomes (eg dementia) but it’s hard to know if it’s the drug or the reduced obesity. |