Failed FET - try for a fresh transfer?

[Anonymous]

I'm the one who posted about the first failed transfer at SG. We ended up with 2 blasts, one was PGS normal. I ended up miscarrying at 6 weeks. So, that made me really question PGS. Since it doesn't test for all abnormalities, is it worth It? The MC rate is supposed to be less than 10% for PGS embies!

I had my WTF appt today and Dr. Khan was great. I'm repeated loss blood work done since it would make me feel better, even though this was my first pregnancy and MC.

Anyway, Dr. Khan said if I want, I could do a fresh transfer and PGS the rest, if I have any frosties. After all, the embie that was PGS normal was my best quality, an AA, so they would have transferred it anyway. The abnormal was an AB.

Thoughts on trying a fresh next cycle and testing any frosties? My hesitation is that my body will be messed up from the stims and won't be properly "prepped" for the transfer.

[Anonymous]

Remind us how old you are? If you want to test all and freeze all, the success rates are about the same now as fresh.

[Anonymous]

Turning 37 soon. Wow, the stats are that similar? I'm 99% sure I'm going to do a fresh.

[Anonymous]

Definitely do PGS. It's not guarantee but it gives you a better chance.

[Anonymous]

Anonymous wrote:Definitely do PGS. It's not guarantee but it gives you a better chance.

This.

Did you do D&C and testing of tissues of miscarriage?

[Anonymous]

Nope. The MC was natural and happened at 6 weeks. PGS didn't work out for me last time!

[Anonymous]

I would PGS test. I got pregnant using clomid and the baby had Trisomy 18 and we opted to terminate. When we did IVF, less than half of my embryo's tested positive. No way would I risk going through that again.

[Anonymous]

Recent studies show that FET now has better pregnancy rates than fresh cycles. The freezing process has gotten better, and your body is in a physiologically more similar to a normal pregnancy state when you didn't just finish a stim cycle.

[Anonymous]

https://www.ccrmivf.com/about-us/frozen-ivf-advantage/

[Anonymous]

These advantages are all conditional on there being sufficiently high quality blasts to freeze and transfer on a later cycle. Success rates in fresh cycles where there are excess (i.e., supernumerary) blasts available for preservation are actually higher than in matched frozen cycles. See Salha (2000), Hill (2013), Pereira (2016). In other words, the presence of freeze-worthy blasts is itself predictive of higher egg and embryo quality.

[Anonymous]

Hit post too soon. Although there are confounding factors, and specific reasons why one might want to intentionally defer a fresh transfer (high progesterone, PCOS, or an indication for PGS), generally ESET success rates are higher than matched frozen cycles.

[Anonymous]

I went thru my 1st IVF-ICSI at age 37 and ended with only one fertilized embryo, so we transferred that only one on Day2 (4cells) thru fresh transfer. This was my only successful IVF baby.
All my subsequent IVF-ICSI for sibling resulted in MC. When we started on baby2, I was already 40. Given that we chose PGS (three day5 blastocyst for testing), and only one was normal, transferred one and only one normal and it did not implant. I wonder to this day that if I did not have that one normal blastocyst thru the stress of PGS testing, would that one normal successful implanted and would I have had a live baby? This is all "what if" talking, but you might not need to PGS at your age now.

[Anonymous]

I very much like this comment. Thanks. I didn't realize I was waiting for someone to tell me to try a fresh until your post. Lol. I'm 99% sure I'm going to try for fresh. I did shared risk with SG, so if this doesn't work I still have 4 more shots.

My friend is 3 years younger than me. She did a fresh with 2 embies last year, BFN. She did 2 FETs with PGS embies, BFN, plus she's been on steroids and antibiotics and has had end scratches before each transger and a uterine biopsy done. She has one embie left after 4 rounds of IVF. So, who the hell truly knows what works and what doesn't.

It seems like every doc has a different opinion and quotes different stats. My gut is to give fresh a shot. I was SO against not doing PGS prior to my MC, but after doing through it and having the doc tell me PGS can't test for all the potential problems...I feel like I should go for it.

All of my embies made it to blast (only 4 fertilized), but 2 of them stop growing on day 6, right before freeze. I always wonder if I would have transferred a couple fresh, would they have made it?

[Anonymous]

Good luck!! And if you are planning for a sibling and your finance allows it, might consider banking now since you are still younger now than trying later.

[Anonymous]

Woops, I misread your first post. Your plan is to do a fresh transfer of fresh blastocyst (or cleaving embryo) and test the remainder, correct? That sounds like a plan to me, too. Good luck!