recurrent chemical pregnancies with genetically tested embryos in IVF?
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Anonymous
| Anyone have this? Did they figure out why, resolve it? Thanks. I am already on baby aspirin & LOvenox (2 very minor things came up in my clotting panel), and obviously I am taking progesterone support (PIO shots). What could explain repeated chemical pregnancies with genetically tested embryos? P.S. I've had a baby before, so whatever it was, it was clearly overcome once? Now all my tested embryos are causing chemical pregnancies (3 of them!). Thanks. |
Anonymous
The baby aspirin and the lovenox are for clotting issues. Did you also get an autoimmune panel done? If you have autoimmune issues you might need something like prednisone or IVIg or other immune treatments. Theory is that your body attacks an embryo as a foreign intruder and that many immune issues develop after a healthy first pregnancy -- especially if that pregnancy was a boy. Also, did you get your thyroid tested? Any TSH, T4, or thyroid antibody issues? |
Anonymous
|
TsH is normal.
Never had immune testing I've had 2 babies before I'm trying to conceive #3 One chemical was before D.C. 1, one chemical was before D.C. 2, and 2 chemicals in a row (with CGH normals) trying for #3 |
Anonymous
Ah, I thought you meant 3 chemicals in a row. Seeing as you had chemicals before each of your two successful ones, I guess I'd just keep trying. Ask your doctor but it doesn't sound like anything extraordinary is going on (which I would suspect if you were getting multiple ones in a row with no success). Sucks though especially with IVF. 
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Anonymous
| 2 chemicals in a row this time. 4 chemicals total. 1 before each kid. But 2 in a row now with tested embryos. Seems too many to just be bad luck??? |
Anonymous
| Sorry to be more clear 3 of the chemicals were tested embryos - one before D.C. 2, and 2 in a row now. First chemical was untested but IVF |
Anonymous
| Immune panel stat! You can develop those after succesful pregnancies. I was borderline for natural killer cells and put on low dose prednisone and biweekly intralipids (my RE is big on immune testing) and it did the trick. The next transfer is currently 9 weeks old and napping beside me. |
Anonymous
| Who does an immune panel? will my regular RE do it? I am in NYC. |
Anonymous
| Also, this is OP. Two of my chemical pregnancies were before live births. Now I've had 2 more. If I had 2 of them before live births, did I have immune issues back then too? |
Anonymous
Frequently chemicals are just chromosome issues that fail early. but since the recent ones are all tested normal, something else is going on. Since you've had live births, you could have immune issues that developed after the successful pregnancies. |
Anonymous
| OP here: it seems that people think the ONLY explanation left is immune issues since it's not genetic with the embryos, and since I've had live births before? |
Anonymous
Well it could probably be lots of other things but many people on this board, myself included, have experience with immune issues. So that's what we tend to think of for otherwise "unexplained" cases. Though yours is not classic since you had a second healthy pregnancy albeit after a chemical. Most of the immune stuff talks about the first healthy pregnancy being the trigger (or sometimes people never even have a first pregnancy). FYI, my immune issue is thyroid. TSH also perfect. But I have thyroid antibodies, which I had to push to get tested because so many doctors stop with TSH. So not a huge deal in the vast and horrible world of autoimmune issues, but that plus a minor clotting issue seem to have caused my multiple miscarriages after an easy first pregnancy. Do you have any autoimmune diseases in your family? My mother has lupus, grandmother had Sjogrens, so the immune diagnosis didn't come out of the blue for me even though I have always tested negative for the issues my family members have. |
Anonymous
|
So PP how did you treat the anti-thyroid anti-bodies ????
And yes my case is really really perplexing because one chemical pregnancy was before my first kid one was before my second kid and then two now. The last three have been with genetically normal embryos but one of them was right before I got pregnant last time |
Anonymous
Synthroid to make sure the TSH doesn't spike (though it never has before); prednisone; occasional intralipids. |
Anonymous
|
Op here. My tsh in July was 1.7
Prednisone when? During cycle? Did you have success by switching to this? The notion that there's something I'm missing that's causing me to "waste" genetically normal embryos that are not implanting is really scary. |