Decreased ovarian reserve vs. age-related infertility

[Anonymous]

I'm trying to understand the difference between decreased ovarian reserve vs. age-related infertility. For example, a 39 year old woman who has a 1.5 year history of infertility, unable to get pregnant at all, and has good FSH, estrogen, TSH, and AFC but low (undetectable) AMH, would this situation be characterized more as decreased ovarian reserve or age-related infertility?

[Anonymous]

Anonymous wrote:I'm trying to understand the difference between decreased ovarian reserve vs. age-related infertility. For example, a 39 year old woman who has a 1.5 year history of infertility, unable to get pregnant at all, and has good FSH, estrogen, TSH, and AFC but low (undetectable) AMH, would this situation be characterized more as decreased ovarian reserve or age-related infertility?

Given lack of success I would say both but DOR probably more because of low amh.
As I understand it, DOR means low quantity. Age rates infertility is a combo of DOR and low quality. As we age both quantity and quality go down.

[Anonymous]

So if you have low quantity, how does this affect pregnancy rates? If you ovulate every month, don't you still have a reasonable chance of pregnancy? Doesn't DOR just mean you will run out of eggs faster and go into menopause sooner? But it seems that having DOR usually means a difficult time getting pregnant, can someone explain why?

[Anonymous]

Anonymous wrote:So if you have low quantity, how does this affect pregnancy rates? If you ovulate every month, don't you still have a reasonable chance of pregnancy? Doesn't DOR just mean you will run out of eggs faster and go into menopause sooner? But it seems that having DOR usually means a difficult time getting pregnant, can someone explain why?

From what I've read, lower quantity correlates with lower quality, because the good eggs were likely to already have been used up.

[Anonymous]

Anonymous wrote:So if you have low quantity, how does this affect pregnancy rates? If you ovulate every month, don't you still have a reasonable chance of pregnancy? Doesn't DOR just mean you will run out of eggs faster and go into menopause sooner? But it seems that having DOR usually means a difficult time getting pregnant, can someone explain why?

my understanding:

yes, DOR means you will go into menopause earlier. it also means you won't react well to stimulation so ART is less likely to work for you. yes you can get pregnant on your own and this is where age becomes critical. if you are, say, over 40 and have DOR then you odds are not very good.

[Anonymous]

Anonymous wrote:

Anonymous wrote:So if you have low quantity, how does this affect pregnancy rates? If you ovulate every month, don't you still have a reasonable chance of pregnancy? Doesn't DOR just mean you will run out of eggs faster and go into menopause sooner? But it seems that having DOR usually means a difficult time getting pregnant, can someone explain why?

From what I've read, lower quantity correlates with lower quality, because the good eggs were likely to already have been used up.

i don't think the best eggs are used first. it's just that eggs used earlier are by definition younger so less likely to have been corrupted.

[Anonymous]

Starting a topic each day on the same subject is beating the dead horse into the ground. People already answered to you about this. If it's unsatisfactory to you, talk to your RE or go on Pubmed and read scientific studies.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:So if you have low quantity, how does this affect pregnancy rates? If you ovulate every month, don't you still have a reasonable chance of pregnancy? Doesn't DOR just mean you will run out of eggs faster and go into menopause sooner? But it seems that having DOR usually means a difficult time getting pregnant, can someone explain why?

From what I've read, lower quantity correlates with lower quality, because the good eggs were likely to already have been used up.

i don't think the best eggs are used first. it's just that eggs used earlier are by definition younger so less likely to have been corrupted.

Yes, you are right. I remembered wrong.

[Anonymous]

Well, I am 43. I seem to have a crap-load of eggs. They're all just bad; I have gotten pregnant relatively easily over the past 8 years, but I always miscarry. IVF revealed the low quality of the eggs. My doctor says my situation is age-related infertility.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:So if you have low quantity, how does this affect pregnancy rates? If you ovulate every month, don't you still have a reasonable chance of pregnancy? Doesn't DOR just mean you will run out of eggs faster and go into menopause sooner? But it seems that having DOR usually means a difficult time getting pregnant, can someone explain why?

From what I've read, lower quantity correlates with lower quality, because the good eggs were likely to already have been used up.

i don't think the best eggs are used first. it's just that eggs used earlier are by definition younger so less likely to have been corrupted.

After I had two early miscarriages that were likely chromosomal, Dr. Frank. of gw mentioned my body was mistakenly sending bad eggs before good ones. He was right in that when I ended up doing Pgs about half my eggs were normal. So I understood from him the body is supposed to know to send the best eggs first somehow, and it's not totally random.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:So if you have low quantity, how does this affect pregnancy rates? If you ovulate every month, don't you still have a reasonable chance of pregnancy? Doesn't DOR just mean you will run out of eggs faster and go into menopause sooner? But it seems that having DOR usually means a difficult time getting pregnant, can someone explain why?

From what I've read, lower quantity correlates with lower quality, because the good eggs were likely to already have been used up.

i don't think the best eggs are used first. it's just that eggs used earlier are by definition younger so less likely to have been corrupted.

After I had two early miscarriages that were likely chromosomal, Dr. Frank. of gw mentioned my body was mistakenly sending bad eggs before good ones. He was right in that when I ended up doing Pgs about half my eggs were normal. So I understood from him the body is supposed to know to send the best eggs first somehow, and it's not totally random.

This sounds like a crock honestly.

[Anonymous]

Anonymous wrote:Starting a topic each day on the same subject is beating the dead horse into the ground. People already answered to you about this. If it's unsatisfactory to you, talk to your RE or go on Pubmed and read scientific studies.

I have noticed this too. There seem to be a lot of topics started by the same person with secondary infertility who is confused or unable to accept their diagnosis and cannot mentally move on to donor egg, adoption, or being a parent of an only. I think you need to move on because you seem like you are torturing yourself with all of this agonizing.

[Anonymous]

Anonymous wrote:

Anonymous wrote:Starting a topic each day on the same subject is beating the dead horse into the ground. People already answered to you about this. If it's unsatisfactory to you, talk to your RE or go on Pubmed and read scientific studies.

I have noticed this too. There seem to be a lot of topics started by the same person with secondary infertility who is confused or unable to accept their diagnosis and cannot mentally move on to donor egg, adoption, or being a parent of an only. I think you need to move on because you seem like you are torturing yourself with all of this agonizing.

Goodness, harsh!

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Starting a topic each day on the same subject is beating the dead horse into the ground. People already answered to you about this. If it's unsatisfactory to you, talk to your RE or go on Pubmed and read scientific studies.

I have noticed this too. There seem to be a lot of topics started by the same person with secondary infertility who is confused or unable to accept their diagnosis and cannot mentally move on to donor egg, adoption, or being a parent of an only. I think you need to move on because you seem like you are torturing yourself with all of this agonizing.

Goodness, harsh!

NP. Not harsh, just realistic and trying to help someone who seems to be struggling.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Starting a topic each day on the same subject is beating the dead horse into the ground. People already answered to you about this. If it's unsatisfactory to you, talk to your RE or go on Pubmed and read scientific studies.

I have noticed this too. There seem to be a lot of topics started by the same person with secondary infertility who is confused or unable to accept their diagnosis and cannot mentally move on to donor egg, adoption, or being a parent of an only. I think you need to move on because you seem like you are torturing yourself with all of this agonizing.

Goodness, harsh!

NP. Not harsh, just realistic and trying to help someone who seems to be struggling.

Maybe what helps her at this point is to to discuss the concept of DOR.