Miscarrying a DE with a trisomy

[Anonymous]

After choosing a donor with an excellent history in her prior egg donations, I got one with a trisomy. Learned about the trisomy the hard way -- after getting pregnant, hearing a heartbeat, and then miscarrying at 9 weeks. Has anyone else got a dodgy donor egg?

And, in terms of next steps, does anyone do PGS on donor eggs? The whole POINT of DE is that they're (supposed to be) higher quality eggs than my own, but, without testing, that's not guaranteed.

Anyhow, I have one embryo left in the freezer, and am trying to weigh pros of testing (if it were a dud, I wouldn't go through another mc) and cons ($$$ and possible harm to a potentially perfect embryo). Thoughts?

[Anonymous]

I wouldn't call it a dodgy donor egg, but that's just me. To me none of these eggs are commodities.

To answer your question, if this was a healthy donor, there is a low probability that the last egg carries a trisomy. What does your doctor recommend?

[Anonymous]

How do you know that the egg contributed the extra chromosome, and not the sperm?

[Anonymous]

Anonymous wrote:How do you know that the egg contributed the extra chromosome, and not the sperm?

This

[Anonymous]

So sorry about your loss and the stress of this, OP.

[Anonymous]

OP to 20:12 -- Some labs, including the one that SG uses, can test to determine if the extra chromosome in a trisomy was maternal (from the DE) or paternal. In my case, the lab identified the trisomy from the DE.

My RE recommends trying again with another embryo from the same donor. Other eggs from the donor did not fail for trisomies (that could be detected). RE did not think the PGS testing is necessary, but given a long path to this point, does not object to it, so long as I recognize that PGS has a small chance of harming the embryo.

[Anonymous]

Anonymous wrote:
I wouldn't call it a dodgy donor egg, but that's just me. To me none of these eggs are commodities.

OP here -- Ok, THANK YOU for the correction, straight from the mouth of the high horse. And do you really think I need to be corrected? Do you really think that after doing DE (and the not-so-easy path that usually leads a person to DE) and getting to 9 weeks in a pregnancy, a point where there is a 97+% medical chance the pregnancy will succeed, that I seriously think this was just a F*&%ing widget?

[Anonymous]

Anonymous wrote:

Anonymous wrote:
I wouldn't call it a dodgy donor egg, but that's just me. To me none of these eggs are commodities.

OP here -- Ok, THANK YOU for the correction, straight from the mouth of the high horse. And do you really think I need to be corrected? Do you really think that after doing DE (and the not-so-easy path that usually leads a person to DE) and getting to 9 weeks in a pregnancy, a point where there is a 97+% medical chance the pregnancy will succeed, that I seriously think this was just a F*&%ing widget?

Yikes, OP. I really hope you are seeing a counselor to help you through this.

[Anonymous]

Her angst is understandable considering she is in the midst of a miscarriage…a little compassion people!!!

[Anonymous]

Trisomys can happen at any age...it's just they are less likely the younger you are. I personally know someone who is early 20s with a child with down syndrome (trisomy 21). Since your donor is proven I would chalk it up to bad luck and probably would not test the other embryo but that is just me.

[Anonymous]

Anonymous wrote:Trisomys can happen at any age...it's just they are less likely the younger you are. I personally know someone who is early 20s with a child with down syndrome (trisomy 21). Since your donor is proven I would chalk it up to bad luck and probably would not test the other embryo but that is just me.

+1

Yes, the whole point is to get better eggs. But there are no guarantees in this business.

[Anonymous]

I'm sorry, OP. I'm sorry about your precious child, about the miscarriage, and everything you are going through.

I would chalk this up to bad luck.

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:
I wouldn't call it a dodgy donor egg, but that's just me. To me none of these eggs are commodities.

OP here -- Ok, THANK YOU for the correction, straight from the mouth of the high horse. And do you really think I need to be corrected? Do you really think that after doing DE (and the not-so-easy path that usually leads a person to DE) and getting to 9 weeks in a pregnancy, a point where there is a 97+% medical chance the pregnancy will succeed, that I seriously think this was just a F*&%ing widget?

Yikes, OP. I really hope you are seeing a counselor to help you through this.

DE mom here. I think the commodities post was obnoxious, not at all in line with the usually supportive nature of this forum.

Even young women can produce chromosomally abnormal eggs. I'm sorry, OP. I'm not sure what I'd do as far as transfer the one remaining or start fresh. What do you think you can handle emotionally? How much can you handle financially?

The PGD test is the same fee whether you are testing one or many embryos. Since you only have one frozen I'm guessing you did 3:1 at SG? Do you agree with your RE's recommendation?

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:
I wouldn't call it a dodgy donor egg, but that's just me. To me none of these eggs are commodities.

OP here -- Ok, THANK YOU for the correction, straight from the mouth of the high horse. And do you really think I need to be corrected? Do you really think that after doing DE (and the not-so-easy path that usually leads a person to DE) and getting to 9 weeks in a pregnancy, a point where there is a 97+% medical chance the pregnancy will succeed, that I seriously think this was just a F*&%ing widget?

Yikes, OP. I really hope you are seeing a counselor to help you through this.

DE mom here. I think the commodities post was obnoxious, not at all in line with the usually supportive nature of this forum.

Even young women can produce chromosomally abnormal eggs. I'm sorry, OP. I'm not sure what I'd do as far as transfer the one remaining or start fresh. What do you think you can handle emotionally? How much can you handle financially?

The PGD test is the same fee whether you are testing one or many embryos. Since you only have one frozen I'm guessing you did 3:1 at SG? Do you agree with your RE's recommendation?

Yes, I double support PP's support for OP. See a counselor??...get out of here!! OP, it's incredibly heartbreaking that you MC with an egg that was supposed to be better than your own. I went through a similar situation--but with my own eggs--I MC at the end of the 1st trimester also due to trisonomy. It is such a blow, but you did the right thing in sending the products of conception to be tested so that you have an answer abt which parent provided the defect. If the donor has a history of proven success, then I would take the time that I need to heal and then transfer the second and just pray like hell. I don't think my SGF RE would have recommended spending the flat fee for PGS for just one embryo. I am starting my DE journey this spring/summer and I am on pins and needles for the same reasons as you. There are just no guarantees. Good luck!

[Anonymous]

I think the statistic is that around 3/4 donor eggs are typically nornal - but even forbDE about 1 out of four are abnormal. So it happens. You could do PGZ on FE. We did. Unfortunately that doesn't solve everything either. Since you didn't do it, I would just transfer the frozen, and if it doesn't work, do PGS next time. SG will do it if you want.