4 miscarriages in a row. It’s my egg quality, right?

[Anonymous]

For me it was immunology. 3 miscarriages in a row. With treatment, had a successful medicated iui on the first try. Talk to Dr Abbasi at CFA.

[Anonymous]

Anonymous wrote:For me it was immunology. 3 miscarriages in a row. With treatment, had a successful medicated iui on the first try. Talk to Dr Abbasi at CFA.

OP here - if you don't mind me asking, when were your miscarriages? Did you see a heartbeat with any? I ask because mine have all been at pretty much the exact same point (between 5.5-6.5 weeks before we see a heartbeat with either an empty ultrasound or BO), and from what I've read pre-embryonic losses like those are typically chromosomal issues. Please don't feel like you need to answer if it's triggering.

[Anonymous]

Anonymous wrote:OP here. Sperm and DNA fragmentation are normal. Had endometritis which was treated and normal, no other uterine issues found. Thyroid was good, not just normal, and no symptoms of thyroid issues. I appreciate the suggestions, all, good to think everything through to make sure we haven’t missed anything.

Just to confirm— you repeated the biopsy for endometritis to confirm it was cleared? Antibiotics aren’t 100% for curing it (60-80% cure rate depending on antibiotic used). Have you had a diagnostic hysteroscopy? Dr. McQueen (RPL specialist from UNiversity of Chicago) just did an Instagram live with the egg whisper last night. Check it out. She has done a lot of interesting research on RPL and endometritis and suggests a hysteroscopy to look for the cause of it.

[Anonymous]

Anonymous wrote:

Anonymous wrote:OP here. Sperm and DNA fragmentation are normal. Had endometritis which was treated and normal, no other uterine issues found. Thyroid was good, not just normal, and no symptoms of thyroid issues. I appreciate the suggestions, all, good to think everything through to make sure we haven’t missed anything.

Just to confirm— you repeated the biopsy for endometritis to confirm it was cleared? Antibiotics aren’t 100% for curing it (60-80% cure rate depending on antibiotic used). Have you had a diagnostic hysteroscopy? Dr. McQueen (RPL specialist from UNiversity of Chicago) just did an Instagram live with the egg whisper last night. Check it out. She has done a lot of interesting research on RPL and endometritis and suggests a hysteroscopy to look for the cause of it.

Yes I did. I actually had a few threads on here in the last few months about it. It took multiple rounds of Cipro and Flagyl, but I finally got a clean biopsy in December. I'm pretty sure I know where and when I picked up antibiotic resistant bacteria in my uterus, so now that it's clear I feel decently confident (as confident as you can about anything after all of this) that it's actually gone. Currently miscarrying now, so conception has happened since the endometritis was cleared. Checking out the Instagram now, thanks.

[Anonymous]

I'm in a similar boat to you- I've had four miscarriages in a row and all of my tests have come back normal, except for endometritis which I cleared with antibiotics before my last miscarriage. The only real difference is that I have not gone down the IVF route yet because I do get pregnant quite easily. My RE is kind of out of ideas and I don't really want the immunology rabbit hole. I've told myself that I will go to 7 miscarriages before I look into DE or surrogacy, but it only takes me 1-2 months to get pregnant, so it doesn't take as long. I'm 35 now, I've been trying for 2.5 years, and I'm thinking I will try for another 9 months to another year. If it took me 9-15 months between pregnancies, I think I would make that shift a lot sooner. I feel for you so much. It sucks so much, and it feels impossible to know if anything will ultimately be successful. Wishing you the best of luck and keep us posted.

[Anonymous]

If it’s not sperm as you’ve said, then I’d look into donor egg ASAP.

Sorry OP. This is hard.

[Anonymous]

Anonymous wrote:I'm in a similar boat to you- I've had four miscarriages in a row and all of my tests have come back normal, except for endometritis which I cleared with antibiotics before my last miscarriage. The only real difference is that I have not gone down the IVF route yet because I do get pregnant quite easily. My RE is kind of out of ideas and I don't really want the immunology rabbit hole. I've told myself that I will go to 7 miscarriages before I look into DE or surrogacy, but it only takes me 1-2 months to get pregnant, so it doesn't take as long. I'm 35 now, I've been trying for 2.5 years, and I'm thinking I will try for another 9 months to another year. If it took me 9-15 months between pregnancies, I think I would make that shift a lot sooner. I feel for you so much. It sucks so much, and it feels impossible to know if anything will ultimately be successful. Wishing you the best of luck and keep us posted.

karyotype

[Anonymous]

Get the book “the infertility cure” by acupuncturist randine lewis. Try this with the treatments. It works!!!

[Anonymous]

Have you talked to your RE about MTHFR? The women in my life who have experienced reoccurring MC (think 7+ MC) was due to MTHFR. Some have eventually gone on to have a successful pregnancy. Others adopted.

[Anonymous]

I admit that I don’t know much about any of this but since you asked about thyroid I’d make sure your levels of free t4 are in a normal range. Did they check for ANA
(Antinuclear antibodies)?

[Anonymous]

Your history sounds similar to my sister's...i.e. was able to get pregnant, but kept having first trimester losses. She now has 2 kids (though also had a week 11 loss in between them). We have auto-immune issues in our family, and that's basically the only thing that could explain her losses.

What worked for her was baby aspirin and progesterone support. I think an immunology work up is a good idea, but you could also just ask a doctor if they are willing to oversee a baby aspirin protocol. Not all doctors agree with it, but that's what worked for her.

[Anonymous]

Are you taking Coq10? It's one of those things 'might help, doesn't hurt'. One of the takeaways I got from the It Starts With the Egg book.

It worked for me - twice. But YMMV.

[Anonymous]

OP - definitely get the immuno work up (which totally sucks). Like you, I had several miscarriages all around the same time but did see heartbeats. That said, my doctor at SG suggested the immuno work-up because of my ethnic background. We discovered I had a clotting issue - which caused the miscarriages. Once I was on a treatment plan (and I threw in some natural vitamin D), I finally carried to term.

[Anonymous]

OP here. I just had a consult with Dr. Abbasi and she reviewed my prior test results and confirmed it's egg quality, which is consistent with what my primary RE has been saying. She recommended donor eggs or adoption, which I think is the closure that we've been looking for.

[Anonymous]

Anonymous wrote:OP here. I just had a consult with Dr. Abbasi and she reviewed my prior test results and confirmed it's egg quality, which is consistent with what my primary RE has been saying. She recommended donor eggs or adoption, which I think is the closure that we've been looking for.

Hugs, op.