Both rat studies and the new human study show negative effects of ADHD medication on brain function. That's separate from the differences between NT and ADHD brain function. The effects may only be transient, but they're not in rat studies. |
Citations? |
14:50 here- I posted earlier on a smaller study showing negative effects of stimulant medication on typical brains. I have never seen a study on permanent, negative effects of medication on an ADHD brain. I would be interested in a citation as well. I do agree that it's difficult to tease out what the effects of medication might be vs. the effects of executive functioning disorders- but EF impairment is selective. Ask anyone whose child is gifted and has ADHD. |
If you dig into the cited researcher's work, it actually suggests that the same effect of medication that can be problematic in someone without ADHD could be beneficial for someone with ADHD. One of the primary concerns raised for people without ADHD is that stimulant medications may, over time, shift the excitation-inhibition balance in the brain toward inhibition, and this resulting imbalance could reduce certain brain functions in someone without ADHD. But some research has shown a correlation between ADHD and an imbalance in the brain in favor of excitation, which means that a shift away from excitation and toward inhibition (such as that shown by ADHD stimulant medications) may actually be a positive thing for someone with ADHD, bringing their brain functioning more in balance in the long run. |
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Yes, if they start analyzing stimulant effect regardless of whether patients tested have ADHD (and what kind!), then the studies are worthless. It's obvious that an ADHD brain needing synaptic stimulation will react differently than a non-ADHD brain. Also, subjects taking pills on a strict routine because they have severe ADHD have a different medication regimen than people just looking for a high, or wanting to pull all-nighters. |
14:50 here- can you provide the citations? I'm not challenging your assertion- I'm just curious to read the research. We're considering medication for our DS12 but are a bit concerned about permanent effects. Thanks. |
That is the goal, the hope. I haven't seen any studies showing that it happens. |
Rewire the brain in what way? |
Read above re: excitation-inhibition |
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I have heard anecdotally that some people think it shot their metabolism and lead to weight problems. Makes some sense. if your appetite is low on them and you aren't eating enough calories for a long period of time, your metabolism gets messed up.
Have also heard people complain by adulthood they habituated to it and could not keep going up in dose to it became somewhat useless. If my kid ends up needing meds, I will probably avoid stimulants. |
Well, the problem is that the other medications don’t really work very well for most people with ADHD. The non-stimulants are all basically just sedative variants so help a little bit with hyperactivity and impulsivity but don’t really help the attention piece, and have their own set of side effects. So for people who really need medication, the stimulants are generally the safest and most effective, unfortunately. |
| This whole thread just really underlined why we need more studies that use brain imaging to establish a baseline and and compare changes to a control group. Until we have those studies, this is all basically just guessing. I think a lot of that work is in progress, so we’ll probably have the answers for our grandchildren. |
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I don’t know the science of it all so I will just speak to my ADHD-I son. We started meds one year ago at age 8. First adderall then switched to Ritalin family. On both meds we take weekends off, holiday breaks off and the summer off. Happy to report the days he’s not on meds he is the same as before we started meds. He can hyperfocus on Legos, robots and reading (3 favorite actitivies) for hours on end.
I suggest taking more med breaks if you can. You never know what could be his his evolving personality since you started meds fairly young. |
Agreed. No need for that nasty remark. |
Really? What I’ve read about Straterra is that some studies show it works almost as well as stimulents, but has to be taken long-term before achieving those effects. Like 9-plus months... |