PGS after multiple miscarriages

[Anonymous]

agree with the 1047 poster. Have them check for immune disorders and clotting issues. So, I had mulitiple miscarriages and failed iVFs. They never actually did any blood work for clotting disorders or immune issues (NO CLUE WHY) and i didnt know back then to ask. BUT, empirically, they put me on aspirin and prednisone to "see if it would help" and it did. Subsequently after my IVF baby turned 1 year old, I discovered that i have a serious clotting disorder. So, I believe that that was the cuase of all the miscarriages and failed implantations and that the reason my 4th try ended up working was because of the aspirin and prednisone.

[Anonymous]

Anonymous wrote:

Anonymous wrote:I had multiple miscarriages starting in my late 20s. SG suggested IVF with PGS for me but that didn't seem to fit since we had no trouble actually getting pregnant. They said if that didn't work I may need a gestational surrogate. Lucky for me there was another answer.

I went to AEB and Dr. Abbasi for another opinion and we found fairly extensive immune issues and clotting factors. Had my first live birth at 32, than again at 34 and 35 with immune treatments.

Thanks so much for your response! Do you mind me asking what immune issues they found and what treatment protocol worked for you? I feel like I’ve done every test under the sun. Not sure what else is left!

We found lots of stuff. Some HLA incompatibilities plus elevated NKs and TNF, several clotting factors and I also have a genetic haplotype that predisposes me to autoimmune conditions. I ended up being on various dosages of Neupogen plus prednisone, intralipids, lovenox and synthroid (no ATA just slightly hypo) for my successful pregnancies. This was after still miscarrying twice on IVIG. I believe Neupogen was the difference maker all around, but I did still have issues during my pregnancies tied to implantation issues. DC2 had IUGR which we were able to reverse with intralipids and with DC3 I had something called CVP, both of which deal with placental function. I attribute all my immune treatments before DC1 to making that pregnancy a smooth one.

After two failed pregnancies on IVIG protocol AEB put in place, Braverman was the one who prescribed my Neupogen. I have 3 Braverman babies thanks to him! He was the only one prescribing it back in 2011 and I was definitely one of his first round of patients at the time.