These numbers at 42

[Anonymous]

The thing about waiting until Day 5 to do PGS testing is that your embryos may not last that long. I was told better to put them in at Day 3 than leave them until Day 5. This was due to age. So I transferred more on Day 3 due to age (42). Ask the REs about that.

[Anonymous]

Anonymous wrote:

Anonymous wrote:Ivf odds at 41-42 r about 20% overall. If you do get a PGS normal embryo the odds that the normal embryo will work much higher than 20%. At that point age matters much less. That’s also why DE has better success for older people - it gets you the normal embryo.

Wow that's pretty high odds. I was told much lower at age 40 when I went in, I was told 10% or less with IVF and I have ok numbers.

SART data shows around 20% success per patient at the better known clinics. If you consider per retrieval, it'll be lower, so that's probably not too far off.

[Anonymous]

I dont know, I've heard at 42 that IVF is pretty equal to IUI. And I have heard many times that at advanced age, it is best to transfer as early as possible, ruling out PGS and day 5 transfers.

[Anonymous]

Anonymous wrote:I dont know, I've heard at 42 that IVF is pretty equal to IUI. And I have heard many times that at advanced age, it is best to transfer as early as possible, ruling out PGS and day 5 transfers.

Some think that older eggs have a harder shell, such that ICSI and assisted hatching provide an advantage. Those can only be done with IVF. I don't know what the data show about IUI vs IVF for advanced age though.

Data show that day 3 transfers generally have slightly higher pregnancy rates than day 5 transfers, but both have the same live birth rate, meaning that MC rate with day 3 is higher. A number of REs favor day 5 transfers as a means to select for embryos that make it to blast. Most clinics with a good reputation have very good culture conditions such that it's not the lab conditions that are causing embryos to fail to make it to blast. I'm sure there are still differing opinions, but the lab conditions was a big reason some REs recommended day 3 over 5, but that's much less of an issue now at the very good clinics. CCRM in CO made it's name on having a better lab, but I think others have caught up.

If you do a fresh transfer, which you typically do with day 3 (they don't freeze as well), you do also run the risk of poor conditions for implantation, as the stim meds tend to have a negative effect on uterine receptivity. There are REs that highly prefer frozen transfers and some won't do fresh transfers unless its a NCIVF cycle for that reason. I know that there are studies on fresh vs frozen transfer that the REs favoring frozen base their preferences on, but I don't know much about the studies and quality of the data/results.

[Anonymous]

Anonymous wrote:

Anonymous wrote:I am 42 as well and had testing in December. My AMH = 2.55, FSH = 4.1. My office lists test results on a patient portal with and it includes this interpretation.

AMH
Reference Range, Females 41 - 46y: 0.26 - 5.81
Median 0.58
AMH concentrations of >= 1.06 ng/mL is correlated with a better response to ovarian stimulation, produced more retrievable oocytes and higher odds of live birth according to Gleicher et al. Fertility and Sterility. 2010:94:2824-2827.

FSH
Adult Female:
Follicular phase 3.5 - 12.5
Ovulation phase 4.7 - 21.5
Luteal phase 1.7 - 7.7
Postmenopausal 25.8 - 134.8

Your levels are good and as PP said means you will likely respond well to IVF. I had miscarriage last fall and then did 2 rounds of egg retrievals this past winter. They got 13 eggs and then 14 eggs. From those 4 blasts and 5 blasts. So far they have put in 7 w/o success. Waiting to do the FET on the last two. So as you see, you may generate a eggs/embryos but not take home a baby.

I wish you all the best luck!

PP,were these untested 5 day blasts?

Yes. The 9 blasts from earlier this winter are untested - my doctor said that at my age the expectation is 1-2 of the nine would be PGS normal but of course at low numbers it could end up being zero or three.