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[quote=Anonymous][quote=Anonymous]I dont know, I've heard at 42 that IVF is pretty equal to IUI. And I have heard many times that at advanced age, it is best to transfer as early as possible, ruling out PGS and day 5 transfers.[/quote]

Some think that older eggs have a harder shell, such that ICSI and assisted hatching provide an advantage.  Those can only be done with IVF.  I don't know what the data show about IUI vs IVF for advanced age though.

Data show that day 3 transfers generally have slightly higher pregnancy rates than day 5 transfers, but both have the same live birth rate, meaning that MC rate with day 3 is higher.  A number of REs favor day 5 transfers as a means to select for embryos that make it to blast.  Most clinics with a good reputation have very good culture conditions such that it's not the lab conditions that are causing embryos to fail to make it to blast.  I'm sure there are still differing opinions, but the lab conditions was a big reason some REs recommended day 3 over 5, but that's much less of an issue now at the very good clinics.  CCRM in CO made it's name on having a better lab, but I think others have caught up.

If you do a fresh transfer, which you typically do with day 3 (they don't freeze as well), you do also run the risk of poor conditions for implantation, as the stim meds tend to have a negative effect on uterine receptivity.  There are REs that highly prefer frozen transfers and some won't do fresh transfers unless its a NCIVF cycle for that reason.  I know that there are studies on fresh vs frozen transfer that the REs favoring frozen base their preferences on, but I don't know much about the studies and quality of the data/results.

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