Ivf questions to ask

[Anonymous]

Anonymous wrote:It seems like you’re potentially setting yourself up for massive heartbreak and wasted time and money by skipping these last steps. You’re going through so much, why wouldn’t you just see this through.

Whats giving me pause are the new studies stating testing is not accurate, not fda approved and has a lot of false positives

[Anonymous]

There’s a lot to unpack in that article and I will look at it more closely later.

Know that there are plenty of peer reviewed journal articles supporting PGT-A for women of advanced reproductive age.

Yes, if you get 1-2 embryos then a fresh transfer without makes sense. Some of the Hail Mary clinics like Dr. Davis at Cornell just put in untested day 3s. If you only get a few, ok, sure.

If you have multiple embryos, then PGT-A is very helpful. Otherwise, you are testing them by transferring them. The time, emotional energy, and money of a failed cycle or even facing the decision to TRMR.

[Anonymous]

I would like to suggest the following podcast episodes:

https://podcasts.apple.com/us/podcast/the-egg-whisperer-show/id1253210160?i=1000655686654

https://podcasts.apple.com/us/podcast/the-egg-whisperer-show/id1253210160?i=1000665899033

[Anonymous]

Unless you have religious beliefs opposing the destruction of aneuploid embryos, you shouldn’t exclude testing.

[Anonymous]

Anonymous wrote:I would like to suggest the following podcast episodes:

https://podcasts.apple.com/us/podcast/the-egg-whisperer-show/id1253210160?i=1000655686654

https://podcasts.apple.com/us/podcast/the-egg-whisperer-show/id1253210160?i=1000665899033

Listening now. Did you see this one : https://youtu.be/-5eHi5ywZNY?si=4f-apcbC3RoN0aDh

Dr. Sherman Silber, a renowned pioneer in microsurgery and infertility, is considered one of the world’s leading authorities in the field of infertility.

[Anonymous]

14:00 again -I wanted to follow-up to say that I do understand transferring untested if you only have 1-2, but I would NEVER do it personally. I am way too risk adverse. Having worked with children with chromosomal abnormalities I would not risk it. I would only transfer a euploid embryo at advanced age period.

There are some who get normal babies with an untested embryo at an advanced age, but the possibility of facing a termination or lifetime with a very disabled child or one who dies early is not worth it. Think through all of the consequences and whether find the risk profile for your age acceptable. It’s your choice, but it’s important to go through the various possibilities and then decide.

[Anonymous]

Anonymous wrote:14:00 again -I wanted to follow-up to say that I do understand transferring untested if you only have 1-2, but I would NEVER do it personally. I am way too risk adverse. Having worked with children with chromosomal abnormalities I would not risk it. I would only transfer a euploid embryo at advanced age period.

There are some who get normal babies with an untested embryo at an advanced age, but the possibility of facing a termination or lifetime with a very disabled child or one who dies early is not worth it. Think through all of the consequences and whether find the risk profile for your age acceptable. It’s your choice, but it’s important to go through the various possibilities and then decide.

I raised this with my RE- pgt-a only test for chromosomal abnormalities, nothing else. What she said was , for most of these, implantation won’t happen if it’s abnormal or the pregnancy would result in a miscarriage. There are 2 types of chromosomes abnormalities though that are compatible with life so would implant and could be detected by a blood test early on . But i see your point

[Anonymous]

A friend in her early 40s elected perinatal hospice and gave birth via c-section to a baby with trisomy 13. They were well supported. Sadly, her baby died a few weeks after birth.

I also know a beautiful boy who will likely never live independently. He is missing a portion of one chromosome. It’s a unique issue, not one of the common problems that is screened for during pregnancy, but PGT-A would have detected it. He is the last of 5 children born when mom was in her 40s.

These things are anecdotal, but they shape me and my choices. Each individual and their physician can evaluate what is best for their unique situation.

[Anonymous]

Anonymous wrote:Ohhhh I’d to PGT-A. Age 38: labs were great, 15 mature eggs, 9 blastocysts …2 euploid. Even with a great blast rate and beautiful embryos many were deeply flawed. Not low level mosaic. Bad. I would NOT want to “test” them by undergoing multiple heartbreaking, time consuming transfers.

Normally I advise against PGS testing but in OP's case she needs to know if she needs to do more retrievals or proceed with transfer. Her # of euploid embryos per egg retrieval is probably less than 0.5. She can waste precious time miscarrying. Either PGS or go to donor eggs

[Anonymous]

What are we doing to rule out male factor?
Statistically how many normal embryos and take home babies per IVF cycle?
When will we know if it is time to throw in the towel?
What are the pregnancy risks due to age and IVF? What are realistic chances of vaginal birth? Pros and cons of planned Csec?

[Anonymous]

Anonymous wrote:

Anonymous wrote:Ohhhh I’d to PGT-A. Age 38: labs were great, 15 mature eggs, 9 blastocysts …2 euploid. Even with a great blast rate and beautiful embryos many were deeply flawed. Not low level mosaic. Bad. I would NOT want to “test” them by undergoing multiple heartbreaking, time consuming transfers.

Normally I advise against PGS testing but in OP's case she needs to know if she needs to do more retrievals or proceed with transfer. Her # of euploid embryos per egg retrieval is probably less than 0.5. She can waste precious time miscarrying. Either PGS or go to donor eggs

Can you elaborate more? My RE said my amh was much higher than average for my age and she’s expecting a lot of eggs. I don’t have pcos. We did all tests possible for both partners. I understand what you’re saying though and thinking maybe we should test to stay on the safe side. Main concern: could we lose a potentially good embryo by testing? Ie false positive

[Anonymous]

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:Ohhhh I’d to PGT-A. Age 38: labs were great, 15 mature eggs, 9 blastocysts …2 euploid. Even with a great blast rate and beautiful embryos many were deeply flawed. Not low level mosaic. Bad. I would NOT want to “test” them by undergoing multiple heartbreaking, time consuming transfers.

Normally I advise against PGS testing but in OP's case she needs to know if she needs to do more retrievals or proceed with transfer. Her # of euploid embryos per egg retrieval is probably less than 0.5. She can waste precious time miscarrying. Either PGS or go to donor eggs

Can you elaborate more? My RE said my amh was much higher than average for my age and she’s expecting a lot of eggs. I don’t have pcos. We did all tests possible for both partners. I understand what you’re saying though and thinking maybe we should test to stay on the safe side. Main concern: could we lose a potentially good embryo by testing? Ie false positive

Did you do dna karyotyping for balanced translocations, tests for clotting, immune issues, etc? My understanding is these aren’t typically part of the initial workup and are only investigated further after failures.

[Anonymous]

I am 39 and did icsc with no testing. 20 weeks pregnant and 2 frozen embryos. NIPT is fine and anatomy scan great. My amh is significantly lower than yours. I would only skip icsc if paying for another round of IVF is not a big deal.

[Anonymous]

https://www.facebook.com/share/v/DxSb4a8gW4sW84oz/?mibextid=UalRPS Another take from Dr Kiltz founder of CNY

[Anonymous]

Anonymous wrote:I am 39 and did icsc with no testing. 20 weeks pregnant and 2 frozen embryos. NIPT is fine and anatomy scan great. My amh is significantly lower than yours. I would only skip icsc if paying for another round of IVF is not a big deal.

ISCI is only recommended if there are sperm issues. Got this from multiple REs, natural selection of sperm is the preferred way as the stronger sperm will self-select. What did your dr think about not testing?