Started NC-IVF Today -- Any Advice?

Anonymous
Today was the baseline testing for our first try with Natural Cycle IVF. We're excited and hopeful, and I was wondering if anyone has any advice or words of wisdom?

This is for secondary infertility, by the way. I'm almost 38 and had an ectopic earlier this year.
Anonymous
I just got a negative HPT from my second NCIVF. My advice is to keep your spirits up and be positive no matter what the outcome will be. Also, be prepared emotionally that you might not make it to the egg collection or embryo transfer (I was quite shocked when we didn't the first time, but this apparently happens quite often). Keep yourself busy and away from fertility discussion boards if you make it to 2ww.
Anonymous
Agree w/ PP - be prepared for anything. Cycle may not start, you may not get an egg, you may trigger far earlier than expected, there may not be fertilization or it the embryo may look good but then not make it to transfer.
Anonymous
Be prepared that it might take multiple attempts to get pregnant through NCIVF. Basically, we are all telling you how to deal with disappointments . But look on the bright side - at least this type of IVF is easy on your body and you can do a few of these back to back without skipping a month. Good luck!
Anonymous
I did 3 rounds of NCIVF due to MF issues and all turned up negative. Like the PP said, be prepared for disappointment. All my cycles went great, just none of the embryos stuck. I was 31 at the time.

Good luck to you! Hoping you will have a different outcome. Everyone is different. My advice: Just release control and let the Drs tell you what to do each step of the way.
Anonymous
Thanks everyone! We've budgeted financially and emotionally for three cycles, and I'm hoping we can keep stay relaxed through this whole process. No guarantees.

Good luck to us all!
Anonymous
16:52 poster: have you done any extensive tests on your DH's sperm (like fragmentation testing)? My NCIVF failed twice and we are also dealing with MF (I am fine). I have doubts about how DF selects sperm (based on looks only). It might look fine, but not have all the genetic material for the pregnancy to progress. I wonder whether this can be the cause of your and my failed IVFs. By the way, did you eventually get pregnant? If yes, through what?
Anonymous
Poster 16:52 here...

Thanks for your questions poster 17:03. My husband and I did do extensive testing of his sperm through SCSA Diagnostics and found out that he has severe fragmentation. After finding that out, we decided to move forward with using only frozen donor sperm. I did 2 out of the 3 rounds of NCIVF using frozen sperm and still no luck. FYI...I am supposedly healthy with nothing wrong. (I no longer believe that btw)

We've moved on to stimulated IVF still using frozen donor sperm. Our 1st round was a negative, it was a good cycle for the most part, I was a little oversuppressed from the lupron and was on too low a dose of stims, so neither of the 2 blasts that were transferred stuck. We're about to start our second round of IVF next month.

Despite my experience, I think you bring up some very good points/questions. My gut tells me that all of this ART stuff is mainly a crap shoot with some science mixed in.

But for piece of mind, I highly recommend getting your husbands sperm tested at SCSA Diagnostics. Some RE's write off the results but for us, it gave us a line to cross between using my husband's sperm and donor sperm. Good luck!
Anonymous
17:03 poster here again. I am going to ask my husband to go through a sperm fragmentation test because I don't want to waste time, money and my emotions on another round of NCIVF until I know what's going on with his DNA fragmentation.

Have you done any extensive testing yourself (like biopsy of your uterine lining, screening of your uterus, checking of all your hormones, etc.)? I've done all the tests imaginable and I am fine according to the doctors (except the fact that I am 38). We had a natural pregnancy back in early 2009, but sadly it ended in miscarriage (there were no chromosomal issues, so I don't know why it didn't progress).
Anonymous
"17:03 poster here again. I am going to ask my husband to go through a sperm fragmentation test because I don't want to waste time, money and my emotions on another round of NCIVF until I know what's going on with his DNA fragmentation."

11:51 here. We are actually do this too - we just sent back the sample to SCSA yesterday.
Anonymous
PP, how many NCIVFs did you go through? What prompted you to do this test?
Anonymous
I'm not familiar with sperm fragmentation, but my husband has sperm issues and they seem to be getting worse. We were one of the first couples to go through natural cycle IVF with ICSI which worked for us the first round. Now we are trying for dc #2 and failed one cycle so far. I know we were lucky the first time but I keep thinking there is more we could do about his sperm.
Anonymous
"PP, how many NCIVFs did you go through? What prompted you to do this test?"

We're doing it in part because we're unexplained, and in part because DH is on an SSRI and there was a study linking a different SSRI to high rates of DNA fragmentation, which at least some researchers have extrapolated would occur with any SSRI. And our embryo arrested before transfer, but after day 3, which could mean a sperm issue. So we decided to do the test before we spent any more money.
Anonymous
Sorry, what is SSRI?
Anonymous
Anonymous wrote:I'm not familiar with sperm fragmentation, but my husband has sperm issues and they seem to be getting worse. We were one of the first couples to go through natural cycle IVF with ICSI which worked for us the first round. Now we are trying for dc #2 and failed one cycle so far. I know we were lucky the first time but I keep thinking there is more we could do about his sperm.


There's so much involved in this whole process, but I do believe sometimes it's just luck that determines the outcome. You read stories of women with high FSH, AMA, bunch of other problems getting pregnant when younger women healthy with no definited fertility problems fail to get pregnant through NCIVF. But I do believe if a husband has bad sperm, just ICSI is not a solution.
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