Anonymous
12/03/2025 07:15
Subject: Tirzepatide - how long did it take for side effects to lessen/go away after first injection on lowest dose?
I didn't have side effects, but from what I'm read on Reddit, they do subside after the first couple of shots.
Anonymous
11/30/2025 13:02
Subject: Tirzepatide - how long did it take for side effects to lessen/go away after first injection on lowest dose?
Anonymous wrote:You have to do it as prescribed. I’ve been on & off Zepbound, and the side effects have been bad enough that I keep quitting. Headache and overall feeling very ill are the biggest issues.
On the one hand you say you have to do it as prescribed yet also say you can’t tolerate it as prescribed. Why not try Microdose
Anonymous
11/30/2025 10:58
Subject: Tirzepatide - how long did it take for side effects to lessen/go away after first injection on lowest dose?
You have to do it as prescribed. I’ve been on & off Zepbound, and the side effects have been bad enough that I keep quitting. Headache and overall feeling very ill are the biggest issues.
Anonymous
11/30/2025 10:56
Subject: Tirzepatide - how long did it take for side effects to lessen/go away after first injection on lowest dose?
Anonymous wrote:Read this thread, it discusses this issue and the OP is very helpful and comes back with an update.
https://www.dcurbanmom.com/jforum/posts/list/1296783.page
In the thread I said that my first week was awful, second was slightly better, third was better, and it was about week 4-5 when I started to feel normal and fine. 10 months later I feel nothing around shot days.
This poster took the lowest prescribed dose but still a large dose for body to adjust to. Microdosing people start at like a tenth of what that poster took
Anonymous
11/28/2025 20:23
Subject: Tirzepatide - how long did it take for side effects to lessen/go away after first injection on lowest dose?
I am micro dosing to avoid side effects - Taking 1.0-1.5 for two months now and have lost 15. Slow and low works best for me. I only feel badly the next day after the shot. Dry mouth and a little dizzy/dehydrated. Lots of water and eating Gruns helps.
Anonymous
11/28/2025 00:01
Subject: Tirzepatide - how long did it take for side effects to lessen/go away after first injection on lowest dose?
The first injection was the hardest, but each week it lessened quickly. I’ve been on 2.5 for 10 weeks (down 20 pounds!!), and haven’t had symptoms in at least 6 weeks. However, if/when I go up to the next dose, I expect that I will have symptoms again.
Anonymous
11/27/2025 21:41
Subject: Tirzepatide - how long did it take for side effects to lessen/go away after first injection on lowest dose?
It took me stepping up over a month to have any effects at all.
Anonymous
11/27/2025 21:40
Subject: Tirzepatide - how long did it take for side effects to lessen/go away after first injection on lowest dose?
I never had any.
Anonymous
11/24/2025 19:23
Subject: Tirzepatide - how long did it take for side effects to lessen/go away after first injection on lowest dose?
Anonymous wrote:I got a little nausea the days right after increasing the dose, but not beyond that. Constipation was a problem the first week or two on a higher dose, but manageable with a Ducolax and stool softener every couple days. My biggest issue was constant low back pain, to the point I had an MRI to be sure I didn’t have a disc issue. That pain was the worst of the side effects, but thankfully went away within a month of stopping the shots.
I was on for 4 months, lost 30lbs, have been off for 6 months and no weight gain.
30 pounds in 4 months -- good for you! I have about the same to lose and I pray I can then stop and keep it off. My diet is good and I exercise a lot, it's all been post kids/perimenopause weight.
Anonymous
11/24/2025 11:41
Subject: Tirzepatide - how long did it take for side effects to lessen/go away after first injection on lowest dose?
I got a little nausea the days right after increasing the dose, but not beyond that. Constipation was a problem the first week or two on a higher dose, but manageable with a Ducolax and stool softener every couple days. My biggest issue was constant low back pain, to the point I had an MRI to be sure I didn’t have a disc issue. That pain was the worst of the side effects, but thankfully went away within a month of stopping the shots.
I was on for 4 months, lost 30lbs, have been off for 6 months and no weight gain.
I was on for 4 months, lost 30lbs, have been off for 6 months and no weight gain.
Anonymous
11/24/2025 07:09
Subject: Tirzepatide - how long did it take for side effects to lessen/go away after first injection on lowest dose?
Read this thread, it discusses this issue and the OP is very helpful and comes back with an update.
https://www.dcurbanmom.com/jforum/posts/list/1296783.page
In the thread I said that my first week was awful, second was slightly better, third was better, and it was about week 4-5 when I started to feel normal and fine. 10 months later I feel nothing around shot days.
https://www.dcurbanmom.com/jforum/posts/list/1296783.page
In the thread I said that my first week was awful, second was slightly better, third was better, and it was about week 4-5 when I started to feel normal and fine. 10 months later I feel nothing around shot days.
Anonymous
11/23/2025 19:07
Subject: Tirzepatide - how long did it take for side effects to lessen/go away after first injection on lowest dose?
If it’s going to go away, will stick with it - but it’s rough. Nausea, fatigue, body aches.