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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]OP- your concerns are valid. [/quote]

Yep. It used to be talked about pretty often the link between ozempic and glp1 agonists and cancer. The cancers it’s associated with are aggressive and deadly too. [/quote]

Citations, please, Dr. Probably Lying Bullsh*t[/quote]

It is. Some studies show that Ozempic decreases cancer risk in obese individuals.

https://www.healthline.com/health-news/ozempic-and-weight-loss-drugs-like-wegovy-can-curb-cancer-risks

Some studies have shown a slight increase in risk of one type of thyroid cancer that is often hereditary. Some have shown there is not.  But of you have that type of thyroid cancer in your family, legit doctors won’t prescribe it for you. [/quote]

To be more accurate, the studies linking GLP-1s to one particular type of thyroid cancer are in *rodents* not people. There are four types of thyroid cancer. By far the most common in humans is papillary thyroid carcinoma. The one that was found in rats is medullary thyroid cancer, which is extremely rare in humans. Between 1992 and 2006, there were only 976 cases of medullary thyroid cancer in the U.S.

There are considerable differences in the biology of GLP-1 receptors in human thyroids vs. rodent thyroids, so the contraindication against GLP-1s for anyone with a history or a family history of medullary thyroid cancer is to be super-conservative, not because the studies of GLP-1s in humans found a higher  incidence of medullary thyroid cancer.

Here's a 2024 study published in the British Journal of Medicine of a large Scandinavian cohort, finding no substantially increased risk of thyroid cancer over nearly 4 years for users of GLP-1s:

https://www.bmj.com/content/385/bmj-2023-078225

And, as an n=1, I have papillary thyroid carcinoma (Bethesda Grade VI, so yes, it's real cancer) and I am in an active surveillance program for it. My doctor is the leading endocrinologist expert on papillary thyroid carcinoma in the U.S. I am monitored via ultrasound yearly. I have been on GLP-1s for three years. He has no concern and my cancer hasn't budged.[/quote]

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