Anonymous wrote:Fragile X is a recessive trait that can cause intellectual disabilities.
OP: If you are worried about this, your intended and you can have genetic testing for these things. National Children's did mine.
I didn't marry my cousin but did come from a family with known fragile X and I wanted to make sure I was not a carrier.
Genetic testing is kind of fun.
Anonymous wrote:Anonymous wrote:Anonymous wrote:Anonymous wrote:Any medical professionals out there? What is the effect on offspring, if first cousins keep producing children, generation after generation. Does this do something to their brain?
Inbreeding doubles the risk of birth defects and can trigger latent, recessive genes with regards to rare medical conditions.
For example, the fundamentalist Mormons have terribly high rates of a specific mental retardation that is very, very rare among the general population.
The polygamists? I saw a show about this. And they have as many kids as they can and the children are just completely incapacitated for their whole lives.
Anonymous wrote:Look up the Pakistani population in the UK.
Anonymous wrote:Anonymous wrote:Any medical professionals out there? What is the effect on offspring, if first cousins keep producing children, generation after generation. Does this do something to their brain?
Inbreeding doubles the risk of birth defects and can trigger latent, recessive genes with regards to rare medical conditions.
Anonymous wrote:Anonymous wrote:Any recessive genetic disorders in that family start cropping up.
This.
Which is why marrying a first cousin is illegal in many countries.
Anonymous wrote:Anonymous wrote:Anonymous wrote:Most genetic defects are mutations. They have nothing to do with parents, parents' marriages, and inbreeding.
Genetic defects are mutations that can be passed on to the offspring. If you have two parents that have the same recessive mutation then they have a 1/4 chance of both passing on that gene to their child and cause the manifestation of the disease in that child.
True, but I was pointing out that whether the first person that has the de novo mutation is part of a long line of cousins is irrelevant.
Anonymous wrote:Fragile X is a recessive trait that can cause intellectual disabilities.
OP: If you are worried about this, your intended and you can have genetic testing for these things. National Children's did mine.
I didn't marry my cousin but did come from a family with known fragile X and I wanted to make sure I was not a carrier.
Genetic testing is kind of fun.
Anonymous wrote:Infertility is another side effect. It is epidemic in the middle east, with as many as 25% of all couples unable to reproduce because of consanguinity. Iran pays for in vitro, surrogacy, donor eggs etc at state-run facilities because it has no choice if the population is to survive.
Anonymous wrote:Birth defects and huge rates of learning disabilitys; not to mention it is the poorest place in the US with fewer English speakers than a Mexican border town, just about 40 minutes from Manhattan lies a thundering horde of cousin fuckers....
https://en.m.wikipedia.org/wiki/Kiryas_Joel,_New_York
Anonymous wrote:Anonymous wrote:Most genetic defects are mutations. They have nothing to do with parents, parents' marriages, and inbreeding.
Genetic defects are mutations that can be passed on to the offspring. If you have two parents that have the same recessive mutation then they have a 1/4 chance of both passing on that gene to their child and cause the manifestation of the disease in that child.
Anonymous wrote:Infertility is another side effect. It is epidemic in the middle east, with as many as 25% of all couples unable to reproduce because of consanguinity. Iran pays for in vitro, surrogacy, donor eggs etc at state-run facilities because it has no choice if the population is to survive.
Anonymous wrote:Anonymous wrote:Anonymous wrote:Saudi Arabia, high incidence of inherited conditions.
Yep. Saudi has very high Down Syndrome rates. And around two-thirds of marriages are blood relatives.
PP from the hemophilia correction here. More basic genetics knowledge is really needed on this thread!
Down syndrome is not heritable in almost all cases- it is a trisomy (ie triplicate) of one of the chromosomes. A trisomy occurs spontaneously at a very low rate after cell division. There are a few rare genes that can increase your risk of having a child with Down syndrome (because you tend to produce such trisomies more often) but those are believed to be implicated in only a tiny percentage (<5%) of Down syndrome cases.
Also, from another thread a recessive gene cannot become dominant. It is that you get two copies of the recessive gene, one from each parent, and then you start to express the recessive trait. Inbreeding increases the chance that you will get two copes of a mutant or unusual gene because both your parents originally got it from the same place.
This thread is a walking ad for why smart people should also study STEM fields. Educate your children first.
(A STEM PhD who is not even a biologist but has learned how to think about science)