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[quote=Anonymous]OP, there are a lot of similarities between your life and mine, though I'm in public policy, which I consider to be a bit more flexible than medical research.  I have three children under the age of 7, and a spouse with flexible hours (but like yours, very busy).  The thing that has worked for me is that since having children, I've worked very hard (and purposefully) to manage expectations.  That means that even if I am checking my email all the time, I will not respond during off hours unless it is critical to.  I will respond and tee up emails, but not send them until the next morning.  This has gone very far in helping with work/life balance, and I've never had an issue (I've continued to get big promotions even after I continue to add children).  You have to back this up, of course, with providing colleagues and supervisors the confidence that you will get your job done, and that nothing will fall through the cracks (and that you will be accessible in an emergency).  Oh, and I have to have someone clean my house.  [/quote]

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