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[quote=Anonymous]calories in/ out is only one picture of the story. But humans are complex and not closed systems, and so it is not 'pure physics.' you cannot control all the variables the way you can (or should) in lab tests.

inflammation, which is actually produced by excess fat among other things, impacts gut microbiome and fat storage. Gut microbiome definitely impacts fat storage/absorption--there are obesogenic bacteria. quality of nutrition is huge. calories from different foods have a huge impact on appetite, insulin, and that regulates hunger and fat storage.  the more crap you eat, the crappier gut bacteria, insulin resistance, etc you have which drives you to eat more and more while being less and less nourished.

Its not calories in calories out that matter so much as garbage in/garbage out. The more we learn about the impact of highly processed foods, the clearer it is that the quality of food has a huge impact on health, weight, hunger, etc.  So its a complex mechanism. But food quality is number one thing to change obesity....if you focus on that, calories matter far less, until you are looking to shave off those last 5-10  lbs.

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