Reply to is RKFJr's "Tylenol(TM) causes autism" just a shakedown for extortion money from the company?

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Reply to "is RKFJr's "Tylenol(TM) causes autism" just a shakedown for extortion money from the company? "

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[quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous][quote=Anonymous]I don’t know why all of you are getting worked up over this. You’re free to ingest as much Tylenol as you wish while pregnant. 
It’s still legal.[/quote]

At what point do these recommendations affect what insurance companies will cover or doctors' liability for compliant or non-compliant advice?[/quote]

lol DCUM freaking out that Tylenol won’t be covered by insurance. Chefs kiss. [/quote]

It's not about insurance coverage. It's about misleading information -- deliberately wrong information.

Tylenol is safe in pregnancy. The other options OTC are not, especially past the 30 week time. And untreated fever in pregnancy really IS connected to autism.[/quote]

And what will end up happening after this is women leaving fever untreated or thinking "I heard Tylenol is bad, I will take Ibuprofen instead." 
[/quote]

The risk is premature closure of the PDA [i]in utero[/i], leading to fetal death.

[b]Tylenol is safe in pregnancy.[/b][/quote]

How do you know?[/quote]

Because a giant study of 2.5 million children which controlled for genetic and familial factors found that any correlation with autism disappeared once those confounding factors were controlled for. In other words, the correlation found in some studies is related to confounds - genetics of who is more likely to take tylenol due to other predisposing factors. [/quote]

That’d be a totally satisfactory response if there weren’t studies pointing in the other direction, but there are. Why don’t you credit those?[/quote]

Because those studies do not control for confounding factors. They are lower quality studies. [/quote]

They claim they do. One is literally called “Use of Negative Control Exposure Analysis to Evaluate Confounding: An Example of Acetaminophen Exposure and Attention-Deficit/Hyperactivity Disorder in Nurses' Health Study II.”

Can you explain what how they are of lower quality? Or is it just that you’re heard smart people you trust say they’re of lower quality?[/quote]

Much smaller sample size, limited to females in the nursing profession, does not account for confounding as well as the swiss study. "However, we cannot rule out the possibility of other uncontrolled risk factors for ADHD that are uniquely correlated with the use of acetaminophen during the pregnancy period"

No, not as high quality as the swiss study.

[/quote]

1. Why does small sample size matter? I get that it can be a problem in some studies where statistical significance goes unachieved, but statistical significance was achieved here. It’s not like we just chuck out existing studies when a bigger one comes along.

2. You’re right that you generally want a big, diverse study, but that’s usually because you want to make sure you’re not overlooking idiosyncratic results that occur in some edge case. In other words, if you want to prove that fancy new drug X is safe and effective for adults, you should recruit a robust mix of people lest you discover that it actually isn’t so good for a subset of people. (For an interesting read, check out the history of Bidil, a drug that was—controversially—approved to treat congestive heart failure in black people but not white people.) But you’re kind of inverting this logic. You’re suggesting that if a big robust study finds no association, then it must be that an association observed in a less representative study must be wrong. That doesn’t follow.

3. Saying that they can’t rule out the possibility of uncontrolled risk factors doesn’t mean that uncontrolled risk factors exist, much less that they account for all of the findings, not just in this study but all of the ones outside of Sweden. [/quote]

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