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[quote=Anonymous]The post-mortem diagnosis of heat-related deaths presents certain difficulties.

Firstly, pre-terminal or terminal body temperatures are often not available. Additionally, naked-eye and microscopic findings are non-specific or inconclusive and depend on the duration of survival after exposure.

The diagnosis of hyperthermia is based on scene investigation, the circumstances of death, and the reasonable exclusion of other causes of death.

A heat-related cause of death may be assumed if the investigations provide compelling evidence of continuous exposure to a hot environment, and fail to identify an independent cause of death (Nixdorf-Miller et al 2006, and Palmiere and Mangin 2013).
The non-specific post-mortem findings in cases of fatal heatstroke include: pulmonary and cerebral oedema, necrosis of the liver, neuronal degeneration of the brain, rhabdomyolysis (breakdown of muscle), tubular casts in the kidneys and signs of disseminated intravascular coagulation e.g. fibrin thrombi in small blood vessels (Palmiere and Mangin 2013).

The post-mortem biochemistry findings are related to dehydration, electrolyte disturbance and skeletal muscle damage. They include increased serum creatinine, mild-to-moderate elevation of urea, and myoglobinuria, however, the diagnosis of heat-related fatalities cannot be based on post-mortem biochemical analyses alone (Palmiere and Mangin 2013).

Read more: http://www.forensicmed.co.uk/pathology/pathophysiology-of-heat-related-illness-and-death/[/quote]

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