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Perimenopause, Menopause, and Beyond
Reply to "Topical estradiol cream felt systemically "
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[quote=Anonymous][quote=Anonymous]Yes, it’s systemic. Your bones have estrogen receptors. Your brain has estrogen receptors. Your cardiovascular system has estrogen receptors. Your skin has estrogen receptors. Your GI tract has estrogen receptors. Parts of your body that regulate metabolism have estrogen receptors. Your joints have estrogen receptors. Your nervous system has estrogen receptors. These receptors need to bind to estrogen for these systems to function optimally. An abrupt drop-off in estrogen — as happens during peri and menopause — prevents these systems from functioning well. Any doctor or internet rando who is talking only about the risks of HRT, without also considering the risks of NOT taking HRT, hasn’t done their homework. [/quote] The OP is talking about the vaginal insert, which is supposed to be very low dose and only act locally in that area. It’s not the same category as what is usually called HRT. But I have heard people say it seems to have systemic effects.[/quote]
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