Anonymous
08/25/2025 14:48
Subject: Topical estradiol cream felt systemically
If you have sex the night you out it in, do the deed before. Otherwise he will pull out your cream. Don't know if semen dilutes it. Ask Gemini. Or your doc.
I use vaginal weights and the cream sticks to it so I asked about how long...overnight you have absorbed it.
My estrogen does nothing for sleep. On the patch I still had poor sleep. The 10 days of oral progesterone, blissful sleep.
I use vaginal weights and the cream sticks to it so I asked about how long...overnight you have absorbed it.
My estrogen does nothing for sleep. On the patch I still had poor sleep. The 10 days of oral progesterone, blissful sleep.
Anonymous
08/25/2025 13:33
Subject: Topical estradiol cream felt systemically
Anonymous wrote:Yes I do notice I sleep better on night’s I use the cream! Haven’t noticed anything different with my hair.
Nice! Thank you!
Anonymous
08/25/2025 13:04
Subject: Topical estradiol cream felt systemically
Yes I do notice I sleep better on night’s I use the cream! Haven’t noticed anything different with my hair.
Anonymous
08/25/2025 13:01
Subject: Topical estradiol cream felt systemically
Anonymous wrote:Oh interesting - my doctor prescribed 2x/week, at night, from the start. The initial higher dose makes some intuitive sense to me though!
She said don’t have sex the same night I use it but the next night is fine. Didn’t ask about condoms, but that might solve the issue.
Would men grow moobs if they get the estradiol on their penis?
Anonymous
08/25/2025 12:57
Subject: Topical estradiol cream felt systemically
Anonymous wrote:I haven't started the estrogen inserts but I probably should, right? I am only on the patch and oral progesterone, but have a prescription for the former.
I thought it was odd that I am supposed to do it 2weeks, daily, and then 2-3 times a week
That's what I was told, too. Dr. also advised using a smaller amount (fingertip) and spreading what's left in the applicator on the external parts. I think the 2 weeks is to build up and establish a base for less frequent use. We wouldn't be considering it if we weren't suffering; although it does seem too good to be true.
Anonymous
08/25/2025 12:15
Subject: Topical estradiol cream felt systemically
Anonymous wrote:Yes, it’s systemic. Your bones have estrogen receptors. Your brain has estrogen receptors. Your cardiovascular system has estrogen receptors. Your skin has estrogen receptors. Your GI tract has estrogen receptors. Parts of your body that regulate metabolism have estrogen receptors. Your joints have estrogen receptors. Your nervous system has estrogen receptors.
These receptors need to bind to estrogen for these systems to function optimally. An abrupt drop-off in estrogen — as happens during peri and menopause — prevents these systems from functioning well.
Any doctor or internet rando who is talking only about the risks of HRT, without also considering the risks of NOT taking HRT, hasn’t done their homework.
The OP is talking about the vaginal insert, which is supposed to be very low dose and only act locally in that area. It’s not the same category as what is usually called HRT. But I have heard people say it seems to have systemic effects.
Anonymous
08/25/2025 12:14
Subject: Topical estradiol cream felt systemically
Anonymous wrote:Anonymous wrote:Yes, it’s systemic. Your bones have estrogen receptors. Your brain has estrogen receptors. Your cardiovascular system has estrogen receptors. Your skin has estrogen receptors. Your GI tract has estrogen receptors. Parts of your body that regulate metabolism have estrogen receptors. Your joints have estrogen receptors. Your nervous system has estrogen receptors.
These receptors need to bind to estrogen for these systems to function optimally. An abrupt drop-off in estrogen — as happens during peri and menopause — prevents these systems from functioning well.
Any doctor or internet rando who is talking only about the risks of HRT, without also considering the risks of NOT taking HRT, hasn’t done their homework.
Um just because there are estrogen receptors multiple places in your body does not mean that we all have to take HRT. I mean we have canniboid and opioid receptors too.
Op here - yeah that reply didn't make sense to me at least as it relates to my specific post.
Anonymous
08/25/2025 12:14
Subject: Topical estradiol cream felt systemically
I got that dosage also. 1 gram of the estrace 2 or 3 times a week. Usually 2. I have had hormone receptive breast cancer and 2 oncologists say that is fine,
Estrogen gets absorbed overnight. The cream is what lingers. I asked doc about that.
Yes sex partner with penis should use condom. I wouldn't oral, stuff tastes nasty I am sure.
Are you postmenopausal? I am.
I notice no sleep difference.
We all shed hair seasonally according to my derm.
Estrogen gets absorbed overnight. The cream is what lingers. I asked doc about that.
Yes sex partner with penis should use condom. I wouldn't oral, stuff tastes nasty I am sure.
Are you postmenopausal? I am.
I notice no sleep difference.
We all shed hair seasonally according to my derm.
Anonymous
08/25/2025 12:12
Subject: Topical estradiol cream felt systemically
Oh interesting - my doctor prescribed 2x/week, at night, from the start. The initial higher dose makes some intuitive sense to me though!
She said don’t have sex the same night I use it but the next night is fine. Didn’t ask about condoms, but that might solve the issue.
She said don’t have sex the same night I use it but the next night is fine. Didn’t ask about condoms, but that might solve the issue.
Anonymous
08/25/2025 12:10
Subject: Topical estradiol cream felt systemically
Anonymous wrote:Yes, it’s systemic. Your bones have estrogen receptors. Your brain has estrogen receptors. Your cardiovascular system has estrogen receptors. Your skin has estrogen receptors. Your GI tract has estrogen receptors. Parts of your body that regulate metabolism have estrogen receptors. Your joints have estrogen receptors. Your nervous system has estrogen receptors.
These receptors need to bind to estrogen for these systems to function optimally. An abrupt drop-off in estrogen — as happens during peri and menopause — prevents these systems from functioning well.
Any doctor or internet rando who is talking only about the risks of HRT, without also considering the risks of NOT taking HRT, hasn’t done their homework.
Um just because there are estrogen receptors multiple places in your body does not mean that we all have to take HRT. I mean we have canniboid and opioid receptors too.
Anonymous
08/25/2025 12:08
Subject: Topical estradiol cream felt systemically
Anonymous wrote:Anonymous wrote:I haven't started the estrogen inserts but I probably should, right? I am only on the patch and oral progesterone, but have a prescription for the former.
I thought it was odd that I am supposed to do it 2weeks, daily, and then 2-3 times a week
I just started the vaginal cream and think this is weird also. Does anyone know why? Also, should we have partners use condoms during this time? Sometimes it takes a day and a half for the unabsorbed cream to pass through, would this be safe for them if there is no physical barrier? How about oral? Do we stop this act too?
OP here. This is the dosage I got too. Seems normal to me. The first part is therapeutic and the second part is maintenance. That said, I use it twice a week at 75% of the dose and have skipped a week before. That is how I know it is having an effect on my deep sleep (for the better) and mood.
Anonymous
08/25/2025 11:57
Subject: Topical estradiol cream felt systemically
Anonymous wrote:I haven't started the estrogen inserts but I probably should, right? I am only on the patch and oral progesterone, but have a prescription for the former.
I thought it was odd that I am supposed to do it 2weeks, daily, and then 2-3 times a week
I just started the vaginal cream and think this is weird also. Does anyone know why? Also, should we have partners use condoms during this time? Sometimes it takes a day and a half for the unabsorbed cream to pass through, would this be safe for them if there is no physical barrier? How about oral? Do we stop this act too?
Anonymous
08/25/2025 11:42
Subject: Topical estradiol cream felt systemically
Anonymous wrote:The hair shedding could actually be a sign that new hair is about to grow in.
Yes, I’d give this a bit of time before you know if you’re losing more than you’re gaining.
Anonymous
08/25/2025 11:23
Subject: Topical estradiol cream felt systemically
Yes, it’s systemic. Your bones have estrogen receptors. Your brain has estrogen receptors. Your cardiovascular system has estrogen receptors. Your skin has estrogen receptors. Your GI tract has estrogen receptors. Parts of your body that regulate metabolism have estrogen receptors. Your joints have estrogen receptors. Your nervous system has estrogen receptors.
These receptors need to bind to estrogen for these systems to function optimally. An abrupt drop-off in estrogen — as happens during peri and menopause — prevents these systems from functioning well.
Any doctor or internet rando who is talking only about the risks of HRT, without also considering the risks of NOT taking HRT, hasn’t done their homework.
These receptors need to bind to estrogen for these systems to function optimally. An abrupt drop-off in estrogen — as happens during peri and menopause — prevents these systems from functioning well.
Any doctor or internet rando who is talking only about the risks of HRT, without also considering the risks of NOT taking HRT, hasn’t done their homework.
Anonymous
08/25/2025 11:14
Subject: Topical estradiol cream felt systemically
The hair shedding could actually be a sign that new hair is about to grow in.