Reply to up to 40% weight reduction from muscle loss with GLP1s?

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Reply to "up to 40% weight reduction from muscle loss with GLP1s?"

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[quote=Anonymous][quote=Anonymous][quote=Anonymous]This makes it sound like taking GLP1s is nothing more than wasting away like you have cachexia:

https://www.fiercebiotech.com/biotech/obesity-regeneron-wants-fill-gaps-cell-therapy-yancopoulos-want-do-try-new-2seventy-crew

Who wants to take GLP1s if 40% of weight loss comes from losing muscle? [/quote]

So, this link is from a biotech company that wants to sell a drug to add to semaglutide to supposedly slow muscle loss. I don't necessarily believe their 40% figure-they don't have hard facts behind it and they have a motive.

I'm on Wegovy, I eat normally (not too much) and healthy, and have lost 1-2 lbs a week-a modest loss. I have not experienced muscle loss. I'm also active physically.[/quote]

There have hardly been any well controlled studies in which the effects on muscle loss were studied. All we are getting are potential findings after the drug has been released onto the population.

You can read the trial results for yourself from a reputable journal:

https://www.nejm.org/doi/full/10.1056/NEJMoa2032183.

There's definitely a large % of weight loss coming from loss of lean mass that's clearly shown in the supplemental data tables. Whether it is more than one would expect from dieting and exercise is the contentious question we don't have good data on yet.

In order to combat muscle loss you need to increase protein intake and exercise, which can be very difficult to do if the drug is suppressing your appetite to reduce calorie intake in the first place.  You ever see body builders?  They do the exact opposite and consume as many calories as possible during phases of anabolism / bulking.

To me it sounds like this is just making you skinny fat, so I'll wait until this topic is analyzed further.  I mean, yeah, I get it. If you have high risk for CVD, diabetes, etc. then there's no point of worrying about this issue.  But for cosmetic purposes I may just hit the gym more.  It's sounds like you'll need to take even more drugs in the future to combat muscle loss.   I don't want to have an entire pharmacy in coursing through my bloodstream. [/quote]

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