Anonymous wrote:

Anonymous wrote:

Anonymous wrote:That's what a sudden and extreme caloric deficit will do. It's important to eat 1g protein per kg of body weight to prevent muscle loss when losing weight, but when you're inducing mild gastroparesis it's impossible to consume that much.

No. Studies have already shown that people who use GLP1s lose a greater percentage of muscle weight than those who lose the same amount of weight without GLP1s.

Right, but as PP suggested, it’s the rapid weight loss that is doing this. Those losing weight without glp1s are not losing weight that quickly.

Not everyone loses weight rapidly on the meds. I'm the pp who's losing one to two pounds a week, which isn't rapid. I also haven't lost muscle and I don't have any loose skin, so I'm very happy with it.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I’m on Wegovy. It’s not the medication. My weight loss clinic does a body scan at each appointment to see what’s going on with body fat and muscle composition and flag any decrease in muscle. Their diet plan includes a lot of protein to make sure patients are maintaining or gaining muscle. I’ve added strength training to my fitness routine to build even more muscle. At my last appointment, I had gained a pound of muscle, and had lost 3 pounds of fat. Eating a lot of protein is key.

But how many people are taking these meds and being scanned or otherwise having their fat vs. muscle loss measured? None of the folks I know on them.

I have listened to some doctors on podcasts (e.g., Peter Attia, who is a proponent of GLP1 medications) and on Doctor Radio discuss concerns about muscle loss with the use of these drugs. Primarily that they're just handed out now like candy, with no monitoring and discussion of the importance of protein intake.

I am one of the last two posters. I think a lot of people get the scans (I do), but if you focus on protein and veggies, everyone will be fine.

I get scanned once a month. I’ve lost some muscle weight but my muscle % is still above average for my height and my fat % has moved way down. Lost 40 lbs.

Where are you getting scanned?

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I’m on Wegovy. It’s not the medication. My weight loss clinic does a body scan at each appointment to see what’s going on with body fat and muscle composition and flag any decrease in muscle. Their diet plan includes a lot of protein to make sure patients are maintaining or gaining muscle. I’ve added strength training to my fitness routine to build even more muscle. At my last appointment, I had gained a pound of muscle, and had lost 3 pounds of fat. Eating a lot of protein is key.

But how many people are taking these meds and being scanned or otherwise having their fat vs. muscle loss measured? None of the folks I know on them.

I have listened to some doctors on podcasts (e.g., Peter Attia, who is a proponent of GLP1 medications) and on Doctor Radio discuss concerns about muscle loss with the use of these drugs. Primarily that they're just handed out now like candy, with no monitoring and discussion of the importance of protein intake.

I am one of the last two posters. I think a lot of people get the scans (I do), but if you focus on protein and veggies, everyone will be fine.

I get scanned once a month. I’ve lost some muscle weight but my muscle % is still above average for my height and my fat % has moved way down. Lost 40 lbs.

Anonymous wrote:

Anonymous wrote:That's what a sudden and extreme caloric deficit will do. It's important to eat 1g protein per kg of body weight to prevent muscle loss when losing weight, but when you're inducing mild gastroparesis it's impossible to consume that much.

No. Studies have already shown that people who use GLP1s lose a greater percentage of muscle weight than those who lose the same amount of weight without GLP1s.

Right, but as PP suggested, it’s the rapid weight loss that is doing this. Those losing weight without glp1s are not losing weight that quickly.

Anonymous wrote:

Anonymous wrote:

Anonymous wrote:I’m on Wegovy. It’s not the medication. My weight loss clinic does a body scan at each appointment to see what’s going on with body fat and muscle composition and flag any decrease in muscle. Their diet plan includes a lot of protein to make sure patients are maintaining or gaining muscle. I’ve added strength training to my fitness routine to build even more muscle. At my last appointment, I had gained a pound of muscle, and had lost 3 pounds of fat. Eating a lot of protein is key.

But how many people are taking these meds and being scanned or otherwise having their fat vs. muscle loss measured? None of the folks I know on them.

I have listened to some doctors on podcasts (e.g., Peter Attia, who is a proponent of GLP1 medications) and on Doctor Radio discuss concerns about muscle loss with the use of these drugs. Primarily that they're just handed out now like candy, with no monitoring and discussion of the importance of protein intake.

I am one of the last two posters. I think a lot of people get the scans (I do), but if you focus on protein and veggies, everyone will be fine.

But a lot of people are not going to eat right while taking the medication.

Anonymous wrote:

Anonymous wrote:This makes it sound like taking GLP1s is nothing more than wasting away like you have cachexia:

https://www.fiercebiotech.com/biotech/obesity-regeneron-wants-fill-gaps-cell-therapy-yancopoulos-want-do-try-new-2seventy-crew

Who wants to take GLP1s if 40% of weight loss comes from losing muscle?

So, this link is from a biotech company that wants to sell a drug to add to semaglutide to supposedly slow muscle loss. I don't necessarily believe their 40% figure-they don't have hard facts behind it and they have a motive.

I'm on Wegovy, I eat normally (not too much) and healthy, and have lost 1-2 lbs a week-a modest loss. I have not experienced muscle loss. I'm also active physically.

There have hardly been any well controlled studies in which the effects on muscle loss were studied. All we are getting are potential findings after the drug has been released onto the population.

You can read the trial results for yourself from a reputable journal:

https://www.nejm.org/doi/full/10.1056/NEJMoa2032183.


There's definitely a large % of weight loss coming from loss of lean mass that's clearly shown in the supplemental data tables. Whether it is more than one would expect from dieting and exercise is the contentious question we don't have good data on yet.

In order to combat muscle loss you need to increase protein intake and exercise, which can be very difficult to do if the drug is suppressing your appetite to reduce calorie intake in the first place. You ever see body builders? They do the exact opposite and consume as many calories as possible during phases of anabolism / bulking.

To me it sounds like this is just making you skinny fat, so I'll wait until this topic is analyzed further. I mean, yeah, I get it. If you have high risk for CVD, diabetes, etc. then there's no point of worrying about this issue. But for cosmetic purposes I may just hit the gym more. It's sounds like you'll need to take even more drugs in the future to combat muscle loss. I don't want to have an entire pharmacy in coursing through my bloodstream.

Anonymous wrote:

Anonymous wrote:I’m on Wegovy. It’s not the medication. My weight loss clinic does a body scan at each appointment to see what’s going on with body fat and muscle composition and flag any decrease in muscle. Their diet plan includes a lot of protein to make sure patients are maintaining or gaining muscle. I’ve added strength training to my fitness routine to build even more muscle. At my last appointment, I had gained a pound of muscle, and had lost 3 pounds of fat. Eating a lot of protein is key.

But how many people are taking these meds and being scanned or otherwise having their fat vs. muscle loss measured? None of the folks I know on them.

I have listened to some doctors on podcasts (e.g., Peter Attia, who is a proponent of GLP1 medications) and on Doctor Radio discuss concerns about muscle loss with the use of these drugs. Primarily that they're just handed out now like candy, with no monitoring and discussion of the importance of protein intake.

I am one of the last two posters. I think a lot of people get the scans (I do), but if you focus on protein and veggies, everyone will be fine.

Anonymous wrote:I’m on Wegovy. It’s not the medication. My weight loss clinic does a body scan at each appointment to see what’s going on with body fat and muscle composition and flag any decrease in muscle. Their diet plan includes a lot of protein to make sure patients are maintaining or gaining muscle. I’ve added strength training to my fitness routine to build even more muscle. At my last appointment, I had gained a pound of muscle, and had lost 3 pounds of fat. Eating a lot of protein is key.

But how many people are taking these meds and being scanned or otherwise having their fat vs. muscle loss measured? None of the folks I know on them.

I have listened to some doctors on podcasts (e.g., Peter Attia, who is a proponent of GLP1 medications) and on Doctor Radio discuss concerns about muscle loss with the use of these drugs. Primarily that they're just handed out now like candy, with no monitoring and discussion of the importance of protein intake.

I’m on Wegovy. It’s not the medication. My weight loss clinic does a body scan at each appointment to see what’s going on with body fat and muscle composition and flag any decrease in muscle. Their diet plan includes a lot of protein to make sure patients are maintaining or gaining muscle. I’ve added strength training to my fitness routine to build even more muscle. At my last appointment, I had gained a pound of muscle, and had lost 3 pounds of fat. Eating a lot of protein is key.

I have lost 60 pounds and only 3-4lbs have been muscle. I get regular scans. I watch my protein intake very carefully.

Anonymous wrote:This makes it sound like taking GLP1s is nothing more than wasting away like you have cachexia:

https://www.fiercebiotech.com/biotech/obesity-regeneron-wants-fill-gaps-cell-therapy-yancopoulos-want-do-try-new-2seventy-crew

Who wants to take GLP1s if 40% of weight loss comes from losing muscle?

So, this link is from a biotech company that wants to sell a drug to add to semaglutide to supposedly slow muscle loss. I don't necessarily believe their 40% figure-they don't have hard facts behind it and they have a motive.

I'm on Wegovy, I eat normally (not too much) and healthy, and have lost 1-2 lbs a week-a modest loss. I have not experienced muscle loss. I'm also active physically.

Or, you can take the drug, and exercise

Anonymous wrote:That's what a sudden and extreme caloric deficit will do. It's important to eat 1g protein per kg of body weight to prevent muscle loss when losing weight, but when you're inducing mild gastroparesis it's impossible to consume that much.

No. Studies have already shown that people who use GLP1s lose a greater percentage of muscle weight than those who lose the same amount of weight without GLP1s.

That's what a sudden and extreme caloric deficit will do. It's important to eat 1g protein per kg of body weight to prevent muscle loss when losing weight, but when you're inducing mild gastroparesis it's impossible to consume that much.

This makes it sound like taking GLP1s is nothing more than wasting away like you have cachexia:

https://www.fiercebiotech.com/biotech/obesity-regeneron-wants-fill-gaps-cell-therapy-yancopoulos-want-do-try-new-2seventy-crew

Who wants to take GLP1s if 40% of weight loss comes from losing muscle?