DE would you select this donor

[Anonymous]

The donor is excellent in every way but she is a carrier of Cystic fibrosis. Would you select her or not a good idea.

[Anonymous]

I would unless, it only takes one gene to pass on.

[Anonymous]

Also to add, we selected a donor who carried a serious disease, but since my husband did not and you need both partners to have the gene. No donor is perfect, but I did avoid auto immune diseases, bipolar, and alcoholism.

[Anonymous]

No way. There are other donors out there. Infertility robs us of so much, one of the few silver linings is getting to screen for stuff like this. Even if DH isn't a carrier your child could still pass it on.

[Anonymous]

Absolutely if DH has cystic fibrosis sequencing (including 5T analysis). Bring a carrier is fine.

[Anonymous]

Yes I would. Being a carrier means nothing, especially if you u are aware. (Assuming the sperm is not from a carrier.)

[Anonymous]

Anonymous wrote:No way. There are other donors out there. Infertility robs us of so much, one of the few silver linings is getting to screen for stuff like this. Even if DH isn't a carrier your child could still pass it on.

Plus 1000

Do you want this or even to pass it along for your child’s heartache.

[Anonymous]

Could you do PGS?

[Anonymous]

Anonymous wrote:Could you do PGS?

I think this is possible. My neighbor's are both carriers of cystic fibrosis; the woman of the couple had a sister who died from it. They did IVF so they could select embryos that did not pass on the disease.

[Anonymous]

You would only do PGD if there was a 1/4 risk. Not just to screen out carrier status. CF is a recessive disease. Carriers are overall healthy (there are only like incredibly rare exceptions to this). Also newsflash, we all carry several recessive diseases, some of which can be screened for, a lot of which can't. So as long as egg donor isn't a carrier for something your husband carries, it's not an issue. Speak to a genetic counselor.

[Anonymous]

Anonymous wrote:No way. There are other donors out there. Infertility robs us of so much, one of the few silver linings is getting to screen for stuff like this. Even if DH isn't a carrier your child could still pass it on.

Your child could only pass on carrier status. Your child's future partner would also have to be a carrier for there to be a risk for your grandchildren. Carriers are healthy.

[Anonymous]

You can avoid bipolar?

[Anonymous]

Anonymous wrote:You would only do PGD if there was a 1/4 risk. Not just to screen out carrier status. CF is a recessive disease. Carriers are overall healthy (there are only like incredibly rare exceptions to this). Also newsflash, we all carry several recessive diseases, some of which can be screened for, a lot of which can't. So as long as egg donor isn't a carrier for something your husband carries, it's not an issue. Speak to a genetic counselor.

This. If your husband or sperm donor is not a carrier, it's not an issue. If husband/sperm donor is a carrier, though, I would not.

For example, I got the full Ashkenazi Jewish panel. I am a carrier for Tay-Sachs disease, which was not a surprise as I had two cousins who died from it decades ago before the disease was widely known. So DH got tested but he is not a carrier, so we were fine to TTC without doing PGS. My sister also was tested when they were TTC and was not a carrier so they did not bother to test her husband (half Jewish).

[Anonymous]

Anonymous wrote:You can avoid bipolar?

Some donors I saw had family history of Bipolar depression. My Dh has already in his side of the family so yeah I didn’t want to risk it. Obviously, depression can come out at any time without a family history.

[Anonymous]

We chose a donor who is a carrier of 2 genetic disorders. Just had to get DH tested to be sure he isn’t a carrier for the same 2. They’re very rare so the likelihood it could ever be a problem is so slim.