Causes for implementation failure

[Anonymous]

Just learned that our first natural FET with a PGS normal embie failed... My RE didn’t sound too concerned calling it bad luck but it was certainly something alerted me, to say the least.... I have no issues with ovulation or egg quality, so it must be either the uterus or immune system or something else? Should I try to find/rule out possible causes before proceedings to the next transfer? Thanks so much for sharing your thoughts.

[Anonymous]

This is your first transfer, correct? I'm not sure that I would pursue "causes" of failure after one transfer. Honestly, sometimes it is just bad luck, and there is no reason. Even in supposedly perfect scenarios, transfer of a PGS normal embryo isn't a guarantee of a BFP.
I'm sorry, OP. I've been there myself, and I get it.

[Anonymous]

i mean, at best, PGS normals have like, 65-70% chance of success, right? even with all other prpoblems ruled out completely.

[Anonymous]

Anonymous wrote:i mean, at best, PGS normals have like, 65-70% chance of success, right? even with all other prpoblems ruled out completely.

I'm the PP at 0927. We were told that it was a bit less than that (50-60%) but...yeah. They can go either way.

[Anonymous]

Mine stuck only on the 3rd FET. all were PGS normals. For me it was the immune system. Based on 1 failure - you can certainly investigate via testing, and try something else, but it's not a pattern, don't fret just yet.

[Anonymous]

Transferred 6 before one took. All great embryos and @perfect” uterus. We have unexplained infertility. Sometimes you’re just on the wrong side of the percentage. Wishing you luck with your next cycle.

[Anonymous]

I thought it’s usually because of immune issues?

[Anonymous]

Anonymous wrote:I thought it’s usually because of immune issues?

Repeated failures, maybe. But, just one or two? No.

[Anonymous]

There are lots of reasons things don't work. If you have plenty of PGS normal embryos, I wouldn't worry about it at all. If you have few, maybe consider an ERA just to be sure transfer timing is good. The transfer protocol is also something to look at. Data show PIO is better than suppositories and some docs don't like doing any sort of natural cycle like transfers (although I'm not sure what the data show on that). Some immune specialists will look at you if you have 1 PGS normal that doesn't take or that miscarries, but I'd be very hesitant to head down that route unless you had more factors pushing you there.