Second Dose -- day 27 at ped's office or wait for day 29 and go to Clinics?

Anonymous
My 3.5 and 1.5 year olds need their second H1N1 shots. I can take them to our pediatrician's office on Thursday (Day 27) -- we have an appointment, or wait until Saturday (day 29) -- and wait in line at a clinic. Obviously the ped's office is easier but I am afraid of doing it before 28 days. What would you do?
Anonymous
Definitely get it at the pediatrician's office so you don't have to wait in line. The window for the shot is 21-35 days.
Anonymous
is the window 21-35 days. i never saw anything about making sure to get it by the 35th day.

lucky you. my peds office has no more shots for kids over 4. i think we're headed for a clinic.
Anonymous
we had the exact same dilemma and chose the ped's office at 27 days.
Anonymous
I'm going to the pedi at 25 days. I think they're pushing 28 days because they want to maximize the number of people getting the first shot.
Anonymous
I think they are pushing 28 days because it is the preferred interval and offers best protection.
Anonymous
yes, 28 days is the optimal window. its absurd to say they are "pushing" 28 days to optimize first doses. for starters, the booster interval recommendations were created before there was a shortage of vaccine.

21 days "may be considered valid" according to the CDC, but 28 days is optimal in terms of immune response. longer than that is also suboptimal.

if I were you, tho, i would go with 27 days -- that's only one day prior to optimal. And also I echo the sentiment, lucky you that your pedi has it!!!!

Anonymous
Wasn't the testing done on children ages 6months-3yrs done with a 3 week interval on the booster?

Anonymous
I would absolutely do the 27 days one. One day is not going to make a huge difference. The CDC says 28 days is ideal but anything past 21 days is "acceptable."
Anonymous
21 days was used in the studies.
http://h1n1.nejm.org/?p=1020
Anonymous
that is what I don't get -- if 21 days was used in the studies, why oh why are they saying 28? If there was some sort of reason I could find, I would feel better about going at 27......but I can't find a reason.
Anonymous
Anonymous wrote:that is what I don't get -- if 21 days was used in the studies, why oh why are they saying 28? If there was some sort of reason I could find, I would feel better about going at 27......but I can't find a reason.


I will throw out four hypotheses, but they are not something I have information on. They may have modeled the protection with at 28 day separation based on 21 day results. Or, they may feel that they were comfortable with the safety of a 21 day separation for the testers but want more safety margin for the general population, who may be less-well monitored. Or perhaps they know that there are certain subgroups who are better off with a greater margin. Or, lastly, this is the way they have done it in the past and so there is a track record of safety and efficacy at 28 days that provides additional confidence over the test data.
Anonymous
I assume (but have no basis for this other than speculation) that the 28 days is just borrowed from the regular flu shot interval for babies, who are supposed to space their two flu shots during their first year of life by 28 days. Have no idea what the basis for that is, but you can probably find something by looking that up.
Anonymous
Well, I hope I didn't do serious harm by getting my son the booster at 25 days. I was just afraid of traveling over Thanksgiving and wanted him to have as much immunity as possible.
Anonymous
Anonymous wrote: its absurd to say they are "pushing" 28 days to optimize first doses. for starters, the booster interval recommendations were created before there was a shortage of vaccine.



Is this true? When did we officially find out that we'd need a second dose? I think it was after the fact that we realized there would be supply problems.

I'm not blaming the govt or anyone else. I'm just trying to get to the bottom of the issue to determine if it's safe and effective to get the shot before 28 days.
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