Davis at Cornell: Your protocol? Fresh transfer?
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Anonymous
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I'm 40 years old with an AMH of 1.2, AFC of 8-9 and FSH of 14.5.
I've done multiple cycles and all of them have involved very high doses of drugs and pushing to Day 5-6 for PGS testing. I have a lot of drop off from Day 3 to Day 5 and struggle to get a decent number of embryos to blast for testing. Of the blasts so far, I miscarried 1 PGS normal and have 1 PGS normal banked. Because time is not on my side, I'm thinking ahead should the next FET not work. For us, I think our next and last step before DE would be Davis. I'm curious about your protocol if you worked with him: Did he do lower dose stims? Did he recommend 3 day transfers if you had limited numbers of blasts? What were his thoughts on PGS? In general, what's his approach or philosophy with DOR/high FSH? |
Anonymous
| You have better numbers than I did in my twenties. He does low dose + clomid in cases of dor or bad quality. He does day 3 for me, since I don't make blasts. I don't know his thoughts on PGS, because I don't make blasts. |
Anonymous
| He does low dose stim with clomid start. I did a variation of this protocol with femara start, low dose stim, HGH, prednisone, metformin and neupogen. A lot better survival rate to day 5, but alas, all of mine were PGS abnormal. Close, but no cigar... |
Anonymous
Did you use femara because of a bad reaction to clomid? Did Dr. Davis prescribe the prednisone, metformin and neupogen (and what were those for)? |
Anonymous
clomid results in thin lining sometimes. Femara is similar, but is used off label. The rest were prescribed by immunologist in home country in Europe. Davis/Cornell don't do immune stuff. |
Anonymous
| I did a three day transfer. When I was there (9 years ago) they did a lot of co-culture, which is only good for 3 day transfers anyway. I had several 8 celled embryos left that I did not transfer on day three but none of them made it to freeze. To this day, I regret not pushing harder to have them freeze something. They had very high standards for what they will freeze. They say this is because they don't want to waste your $$$. But I did not have the money or ability to go back to Cornell for another fresh cycle so I couldn't have another kid even though I wanted one. For me, it would have been worth it to freeze on day 5 even for a 1% chance of a later pregnancy. I realize I am not going to get any sympathy from people trying desperately for DC1. I am sharing this only because if you too can only afford one trip to Cornell, I recommend begging them to lower their standards a bit on what they will freeze for you. And good luck |