Multiple cycles - Lots of eggs - no blast - but pregnant - anyone

[Anonymous]

I usually have lots of eggs retrieved, no 5 day blast. Tried multiple cycles... anyone got pregnant and gave birth? May sound odd I got pregnant 3 times but no live birth yet

[Anonymous]

What are your numbers? AMH, AFC, FSH, Age, etc

[Anonymous]

1.65 amh, 20 AFC, 4.7 FSH, 37 age

[Anonymous]

Are you asking if any PPs got pregnant via IVF but without blasts? I could never get blasts and instead got pregnant -- successfully -- with a 2 day embryo (and twice prior to that with 3 day embryos but those I lost).

[Anonymous]

I tried for 2 years in my late 20's, no pregnancy. I did 2 rounds of IVF with no blasts either time, RE said I needed DE. I had technically normal labwork, but AMH was on the low end of normal for my age (1.06) and my response wasn't great (around 10 eggs retrieved each time). 2 months later I finally got pregnant naturally while on a break and had a successful pregnancy.

[Anonymous]

Op here: yeah I want to know if anyone got pregnant with a history of no blasts in ivf..

[Anonymous]

Your numbers are great. What's the sperm's status?

[Anonymous]

No known issues with the sperm either.. for some reason we don’t make blasts

[Anonymous]

Sorry for your losses.

Possible issues:
1. Protocol isn't the right one for you (# of eggs isn't the only thing to consider)
2. Egg quality is bad and you're not likely to be successful unless you do DE
3. Lab is bad
4. Rare other issue (e.g., genetic problems affecting blast development)

Some people do day 3 transfers, but with the advances in culture and lab techniques, it's not often that it's going to make a huge difference (but it's certainly possible). Time in the lab used to be a bigger concern and most transfers were day 3. Cornell does day 3 transfers, but SG doesn't like to and Dominion was even less flexible after implementing a new policy on day 5 transfers not too long ago. An IUI would also be a way to avoid the lab. SG said they looked at their data and day 3 transfers result in more pregnancies, but not more live births, so they don't like doing them.

I got very few blasts until I did a different protocol with very low doses of meds, but by that point I had just turned 43 and when I had a chemical from the transfer of the 3 blasts (out of 9 eggs - as opposed to 0 or 1 blast from 15 eggs), I decided to cut my losses. I moved on to DE.

[Anonymous]

We did 3 fresh cycles. We produced a grand total of 17 embryos during those cycles, of which only 2 were high quality and 2 were mediocre quality and none made it to blast stage. Never had anything to freeze. We transferred every decent embryo we had as day 3 transfers. The only two viable ones in the bunch are our twin daughters.

Best of luck to you.

[Anonymous]

Anonymous wrote:We did 3 fresh cycles. We produced a grand total of 17 embryos during those cycles, of which only 2 were high quality and 2 were mediocre quality and none made it to blast stage. Never had anything to freeze. We transferred every decent embryo we had as day 3 transfers. The only two viable ones in the bunch are our twin daughters.

Best of luck to you.

I'm not the OP, but I'd like to say thanks for sharing. What was behind your decision to only do fresh cycles and no PGS testing? Did you ever consider PGS testing or were you advised to move directly to fresh transfers (what day did you do the transfer and do you mind sharing your age)? Just curious to know more details of how you handled your situation.

[Anonymous]

Anonymous wrote:Sorry for your losses.

Possible issues:
1. Protocol isn't the right one for you (# of eggs isn't the only thing to consider)
2. Egg quality is bad and you're not likely to be successful unless you do DE
3. Lab is bad
4. Rare other issue (e.g., genetic problems affecting blast development)

Some people do day 3 transfers, but with the advances in culture and lab techniques, it's not often that it's going to make a huge difference (but it's certainly possible). Time in the lab used to be a bigger concern and most transfers were day 3. Cornell does day 3 transfers, but SG doesn't like to and Dominion was even less flexible after implementing a new policy on day 5 transfers not too long ago. An IUI would also be a way to avoid the lab. SG said they looked at their data and day 3 transfers result in more pregnancies, but not more live births, so they don't like doing them.

I got very few blasts until I did a different protocol with very low doses of meds, but by that point I had just turned 43 and when I had a chemical from the transfer of the 3 blasts (out of 9 eggs - as opposed to 0 or 1 blast from 15 eggs), I decided to cut my losses. I moved on to DE.

I’ve done 3 cycles and never gotten a good blast. What was the protocol you tried that finally got you the 3 blasts?

[Anonymous]

Anonymous wrote:

Anonymous wrote:Sorry for your losses.

Possible issues:
1. Protocol isn't the right one for you (# of eggs isn't the only thing to consider)
2. Egg quality is bad and you're not likely to be successful unless you do DE
3. Lab is bad
4. Rare other issue (e.g., genetic problems affecting blast development)

Some people do day 3 transfers, but with the advances in culture and lab techniques, it's not often that it's going to make a huge difference (but it's certainly possible). Time in the lab used to be a bigger concern and most transfers were day 3. Cornell does day 3 transfers, but SG doesn't like to and Dominion was even less flexible after implementing a new policy on day 5 transfers not too long ago. An IUI would also be a way to avoid the lab. SG said they looked at their data and day 3 transfers result in more pregnancies, but not more live births, so they don't like doing them.

I got very few blasts until I did a different protocol with very low doses of meds, but by that point I had just turned 43 and when I had a chemical from the transfer of the 3 blasts (out of 9 eggs - as opposed to 0 or 1 blast from 15 eggs), I decided to cut my losses. I moved on to DE.

I’ve done 3 cycles and never gotten a good blast. What was the protocol you tried that finally got you the 3 blasts?

Minimal stim similar to what Cornell does for DOR, I just didn't have DOR. Starts with Clomid and then adds low doses of typical IVF stims. It was also estrogen primed. I did EPPs prior and found that patches worked better for me than pills.

[Anonymous]

I had high AMH and AFC too, and produced a lot of eggs but the first time: no blasts. Second time: several, and one live birth. We switched protocol in between. antagonist produced no blasts, long agonist produced several, enough to freeze some. But yeah I do know ppl who’ve succeeded with day 3 transfers.

[Anonymous]

All my transfers were day 2 or 3 emrbyos so never blasts. Success in third transfer (fresh after two failed FETs). Dx was unexplained infertility. Good luck!