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Is it going to be this hard to get the booster?
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Anonymous
| Anyone have a sense of whether or not it is going to be as hard to get our kiddos the booster shot as it is to get them the first shot? I'd hate to put her through #1 and then not be able to get her #2, which is really the one that counts. Any ideas? |
Anonymous
| I'm not sure how hard it will be, but still think the first shot is worth it. According to this http://content.nejm.org/cgi/content/full/NEJMoa0908535, approx. 74.5% of 3-11 year olds were immune from the first shot after 21 days. That is a pretty significant percentage. Frankly, I am guessing that most kids will be exposed at least once before they can get that second shot, and i am really hoping to be lucky enough that my kid had a strong reaction to the first shot (but will still get the 2nd). |
Anonymous
|
I'd like to think that if you got the first, they'd set aside your second in your name. If you didn't claim it, you'd lose it after a set amount of time.
But that sounds too logical to be the planned course of action, so it's probably just back to standing in random lines again for #2. |
Anonymous
Broken link... I think this is the one you reference. http://content.nejm.org/cgi/content/abstract/NEJMoa0907413?resourcetype=HWCIT |
Anonymous
| Is there a difference in efficacy between 1 dose of the mist and one dose of the injection? My kids are scheduled for mist next week, but I can switch them to injections. |
Anonymous
not supposed to be a difference. |
Anonymous
| Just went to my pedi last night and got the shot for my son. Before I could ask about scheduling a next dose, they gave me an appointment card for next month. I assume they reserved enough of the vaccine to provide second doses for those who need them. But they are also expecting a much larger shipment within the next month (let's hope they get it). |
Anonymous
I think it's simply too hard to implement with large-scale walk-in clinics. That said, eventually production should catch up with demand, at least for the priority groups. They cranked out the first few batches in a matter of weeks, and meanwhile only the under 10's are in need of a second dose. But I guess it all depends on whether there is any turn in the progression of H1N1 in the population that might scare fence sitters and abstainers into going for their shot. |
Anonymous
Really? Because I would assume the opposite - that they are continuing to give first doses until they run out, especially if they are expecting a second batch in later. I would be pretty upset if I were a parent to another patient and told that I couldn't get my kid a first dose because they were saving a second dose for your kid weeks from now. FWIW, my ped used up all of their doses, even though I have an appointment for my DC in a few weeks for her second dose. I'm expecting to have to stand in a hellish line. And I'm fairly worried about it. |
Anonymous
| Concur, with the NEJM study saying 74.5% of kids 3-11 have immunity 21 days after the first shot, plus a study from one of the European manufacturers (sanofi) that over 90% of kids in the age group had immunity after21 days, it makes most sense for everyone to get their first shot. Even if my child doesn't gain immunity (which I am hoping she does) if 75% of the kids in her class have developed immunity the chance of transmission goes way down. Getting the vax out at this point makes much better sense frojm a public health perspective. |
Anonymous
I made this appointment a week and a half ago when their flu hotline said they had a very small shipment, so it was first call, first scheduled. The last study I read on efficacy in children under 3 (which my son is), is that it only produced about 25% of the response they needed. So "if" that's true, it makes sense to reserve the appropriate second dose for those who need it. Otherwise, it's pointless to waste even one shot on someone who won't receive any real benefit. |
Anonymous
|
http://www3.niaid.nih.gov/news/newsreleases/2009/H1N1PedTrial.htm
In the youngest group, 20 children between 6 months to 35 months old, a single 15-microgram dose of vaccine produced a strong immune response in 25 percent of recipients. [in 8-10 days] The same press release indicated that 36% of 3-10 years old had a strong immune response in 8-10 days. The NEJM study indicates that approx same age group (3-11) 74.5% had a strong immune response after 21 days. I haven't seen the 21 day data for the younger age group, but I hope that immunity continues to build for them as well. In addition, the sanofi data is even more hopeful. http://www.sanofipasteur.com/sanofi-pasteur2/front/index.jsp?siteCode=SP_CORP I don't know enough about public health to know based on this data whether it makes more sense to reserve shots for the young or to immunize more people to hope for herd immunity. Hopefully, we will all be able to easily find second doses for our kids in a few weeks. |
Anonymous
We asked MoCo if DD would have any priority before I stood in line last week to get her the first dose, and they said no priority to received 2nd dose. Just hope more comes in. |
Anonymous
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It is untrue that there is no efficacy difference between the shot and mist.
In children, at least as far as seasonals go, children mount almost TWICE the immune response to the mist. http://content.nejm.org/cgi/content/full/356/7/685 For adults it is the opposite: http://content.nejm.org/cgi/content/full/361/13/1260 My older daughter had some chest congestion remaining from a cold when I got her vaccinated, otherwise I'd have REALLY liked to have gotten her the mist rather than the injectible. Careful looking at any of the efficacy data from outside the US -- they likely contain adjuvants which would make the immune response better than with ours. |