MTHFR

[Anonymous]

I have it and we just found out my husband has it too (compound heterogeneous).

Has anyone found that this had an impact on getting embryos to blast during IVF?

[Anonymous]

OP: Doesn't that sound dirty? I know what it is, can't answer your question, but work in genetics and always wonder why they didn't name that mutation better. Or am I just childish?

[Anonymous]

LOL, yes, it's titled correctly for how much it complicates things....

[Anonymous]

Make sure you take a prenatal with folate, not folic acid

[Anonymous]

Everybody wants to blame MTHFR for everything. It's super common and generally isn't going to cause any problems. Have them give you a fasting homocysteine level test. Only if that is elevated will you need extra folate. If your homocysteine is normal, then you have nothing to worry about. And most people with 2 copies of MTHFR have normal homocysteine.

[Anonymous]

I just replied on another forum about this. Sure, it would be nice to pinpoint MTHFR as the sole source of your issues, and it may matter or it may not. As I said in the other post, I knew a couple of patients who worked with a doctor at SIRM NY (Dr. Wang, no longer there) who saw anecdotally that patients who had trouble making blasts did better when both patients were treated for MTHFR mutations if they both tested positive for it. If you Google on it, there are several articles that show that male MTHFR mutations can be related to poor embryo viability in the lab, implantation failure, and recurrent pregnancy loss due to chromosomal abnormality.

I did a lot of retrievals before I knew my husband was homozygous C677T. I have the A198c mutation. Together it could explain some of our issues making blasts, although age certainly plays a role and perhaps other things also. The treatment is simple enough I wish we had at least known so we could eliminate that as a factor. It can't hurt to treat it and see what happens for you. You could for an Rx for Metanx, or there are several over-the-counter supplements on Amazon that have both methylated folate and vitamin B12. Good luck!