Baby aspirin

[Anonymous]

Has anyone taken baby aspirin for an FET? How long did you take it? Did you start with the transfer or before?

[Anonymous]

Doesn't look like it has any value according to a high-level, high-quality review:

https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0013047/

Cochrane Database of Systematic Reviews: Plain Language Summaries [Internet].
Aspirin for women undergoing assisted reproductive technology (ART).
First published: November 3, 2016.

Background

Aspirin has been commonly used in an attempt to increase the chance of live birth in women undergoing ART. However, there is contradictory evidence on the effectiveness of this treatment and on the appropriate time to commence treatment and its duration. Although physiologically aspirin exerts a beneficial effect on some aspects required for a successful pregnancy, aspirin intake has been also associated with miscarriage and vaginal bleeding. It was, therefore, important to evaluate current evidence on the effectiveness of this treatment.

Study characteristics

We found 13 randomised controlled trials with parallel groups, comparing aspirin with placebo or no treatment in a total of 2653 women undergoing ART. Studies were conducted in the USA and a variety of countries in Europe and Asia. One of the included trials was partly funded by a pharmaceutical company relevant to the intervention. In most of the studies, groups were comparable and the mean age of participants in both groups was 32 years. An identical dose of the intervention was administered in most of the studies and most reported a similar timing of the initiation of aspirin intake. The duration of trial varied across the studies, but was sufficient to provide data on the reported outcomes as respectively investigated by each group. The evidence is current to 9 May 2016.

Key results

There was no evidence of a difference between the groups in rates of live birth, clinical pregnancy, ectopic pregnancy, multiple pregnancy, miscarriage or vaginal bleeding. The number of studies was limited and the quality of the evidence ranged from very low to moderate, while data on complication rates, either during the IVF/ICSI procedure or during pregnancy and childbirth were either very limited or missing. At this second update we were not able to add new data from additional studies, as we found no new RCTs reporting on these outcomes in the prespecified comparisons. Based on the available evidence, we reached the same conclusion as the initial version of the review: no single outcome measure demonstrated a benefit with the use of aspirin. Currently, there is no evidence to support the use of aspirin treatment in order to improve pregnancy rates for a general IVF population.

[Anonymous]

Yes, I took it before, during and after my successful FET. Before that transfer I had 5 unsuccessful transfers, so I do attribute it and Lovenox to my success, scientific studies and "correlation does not prove causation" notwithstanding.

[Anonymous]

Interesting. I took it during my successful IUI cycle because I heard people take it for thin lining (I think I took it from cycle start until a week after the IUI). The study I saw said it didn't actually thicken the lining, but did increase pregnancy rates. I assume the study was specific to women with thin lining but don't remember exactly.

[Anonymous]

I took it on my 4th round and was finally successful. It was the only cycle in which I took it. I believe it helped. I took it before and for the first 9 weeks of pregnancy.

[Anonymous]

PP here again. I wouldn’t take it without a doctors recommendation given that it has also been associated with *causing* miscarriage.

[Anonymous]

Anonymous wrote:Yes, I took it before, during and after my successful FET. Before that transfer I had 5 unsuccessful transfers, so I do attribute it and Lovenox to my success, scientific studies and "correlation does not prove causation" notwithstanding.

Indeed.

[Anonymous]

op here, thanks. Im on my last oe FET. Kind of willing to try a few things that arent proven ...

[Anonymous]

I didn’t take it while undergoing treatment but my high risk doctor just prescribed it at 13 weeks to take throughout pregnancy to prevent pre-eclampsia again.

[Anonymous]

I took it for every cycle, including my successful pregnancies. My high risk OB said it did no harm.

[Anonymous]

I took it and bled in the first trimester - be careful. If it's not prescribed I wouldn't do it. It wasn't prescribed for me but after multiple m/c I decided to take it. Dr was pissed and had me stop after I went in for bleeding.

[Anonymous]

Anonymous wrote:I took it and bled in the first trimester - be careful. If it's not prescribed I wouldn't do it. It wasn't prescribed for me but after multiple m/c I decided to take it. Dr was pissed and had me stop after I went in for bleeding.

Yikes. Did you lose the pregnancy?