Why don't some PGS normals take?

[Anonymous]

If the chromosomes are normal, and presumably no immune issues, why WOULDN'T someone get pregnant off a PGS normal?

[Anonymous]

I got pregnant - miscarried at 6 weeks! disheartening. We did a post-D&C tissue analysis.... normal female fetus.
Totally not sure what is going on.

But as for why someone might not get pregnant, it could depend on whether your uterus is receptive - lining must be ready, etc.

[Anonymous]

Right, there could be receptivity issues. ERA can help with timing, but there can be chemical issues as well. Immune issues is one explanation. I've also heard that even though an embryo can test euploid overall, there can be microdeletions that don't show up in the testing that are important for embryo viability.

[Anonymous]

Anonymous wrote:I got pregnant - miscarried at 6 weeks! disheartening. We did a post-D&C tissue analysis.... normal female fetus.
Totally not sure what is going on.

But as for why someone might not get pregnant, it could depend on whether your uterus is receptive - lining must be ready, etc.

so sorry to hear. i worry that having a normal embryo transferred, i'll be falsely assuming that it'll turn into a live birth easily, a different feeling than just transferring without testing.

[Anonymous]

Anonymous wrote:I got pregnant - miscarried at 6 weeks! disheartening. We did a post-D&C tissue analysis.... normal female fetus.
Totally not sure what is going on.

But as for why someone might not get pregnant, it could depend on whether your uterus is receptive - lining must be ready, etc.

Exact same thing happened to me. I was told most likely something non-chromosomal wrong with the embryo. The words “fluke” and “bad luck” got thrown around a lot. Some doctors will also recommend looking at immune issues, but still some debate over that.

[Anonymous]

Anonymous wrote:Right, there could be receptivity issues. ERA can help with timing, but there can be chemical issues as well. Immune issues is one explanation. I've also heard that even though an embryo can test euploid overall, there can be microdeletions that don't show up in the testing that are important for embryo viability.

+1. For me it was a receptive lining issue and moving my transfer day did the trick. Had previously done 4 ivf’s with PGD that all resulted in chemicals and a frozen that was negative because didn’t thaw well.

[Anonymous]

PGS doesn’t equal pregnancy. It just checks to see if the embryo/s are chromosomially normal. I know it’s hard to see it this way because you would expect it would work.

[Anonymous]

PGS also doesn't test for everything.

[Anonymous]

PGS doesn't test for everything. Your endometrium was not in the receptive window. You may have silent endometriosis or some other condition (other than immune) that prevented implantation.

In natural cycles of fertile women not 100% of times embryos implant. That's why you see on TTC forums a variety of timeframes to conceive.